Gökhan S. Hotamisligil, M.D., Ph.D.



1980-86 Medicine Ankara University Medical School MD
1989-94 Biological Chemistry and Molecular Pharmacology Harvard Medical School,

Boston, MA





1988-89 Genetics Harvard Medical School, Boston, MA Research Fellow
1994-95 Cell Biology Harvard Medical School, Boston, MA Research Fellow

Internships and Residencies:

1986 Pediatrics Royal Hospital for Sick Children, Glasgow, UK
1987-88 Pediatrics Ankara University Medical School, Ankara, Turkey


1995-98 Assistant Professor Department of Nutrition & Division of Biological Sciences (DBS) Harvard School of Public Health
1998-03 Associate Professor Department of Nutrition & Division of Biological Sciences Harvard School of Public Health
2003- Professor Department of Nutrition & Division of Biological Sciences Harvard School of Public Health
2003- Professor Department of Genetics & Complex Diseases Harvard School of Public Health
2003- Chair Department of Genetics & Complex Diseases Harvard School of Public Health
2006- Associate Member Harvard Stem Cell Institute Harvard University


Associate Member

Associate Investigator

MIT-Harvard Broad Institute

Joslin Diabetes Center


Harvard Medical School

2014- Director Sabri Ülker Center for Metabolic Res. Harvard School of Public Health


1989 Harvard University, Division of Medical Sciences Fellowship
1991 Lucille P. Markey Predoctoral Fellowship in Developmental Biology
1994 Mentor based postdoctoral fellowship, American Diabetes Association
1996 Career Development Award, American Diabetes Association
1997 Pew Scholar in Biomedical Sciences, Pew Charitable Trusts
2003 American Asthma Foundation Senior Investigator Award
2003 James Stevens Simmons Endowed Professorship in Genetics & Metabolism
2004 Elected Member, TUBA, Turkish National Academy of Sciences
2004 Recipient of the Scientific and Research Council (TUBITAK) Science Award
2005 Chair of the International Stock Symposium on Obesity and Inflammation
2006 Lawson Wilkins Lecture of the Pediatric Academic Societies, San Francisco, California
2007 Pfizer Visiting Professorship in Diabetes, University of California, Davis, California
2007 Outstanding Scientific Accomplishment Award of the American Diabetes Association
2008 John Denis McGarry Lecture, Montreal Diabetes Research Center
2008 Member, Juvenile Diabetes Research Foundation (JDRF), Research Advisory Board
2008 Co-Chair, 13th EASD/JDRF Oxford Workshop: Inflammation, Islets & Immunity
2008 Kroc Lecture, University of Washington, Seattle
2008 Chair, Juvenile Diabetes Research Foundation Metabolic Control Study Section
2009 Elected Fellow of American Association for Advancement of Science
2010 Judging Committee, Blavatnik Award of the New York Academy of Sciences
2010 Harvard School of Public Health Student Mentoring Award
2010 Wertheimer Award, International Association for the Study of Obesity
2010 Naomi Berrie Award for Outstanding Achievement in Diabetes Research
2010 Selection Committee, Sedat Simavi and Kadir Has Awards in Health and Science
2011 Society Leader and Golden Turk Awards of Turkish-American Community
2011 Keynote Address of the FASEB Conference on Endoplasmic Reticulum
2011 Jose Laguna Garcia Medal and Memorial Lecture, SMB, IUBMB
2011 Sevim Büyükdevrim Memorial Lecture, Diabetes Society, Antalya, Turkey
2012 Richard J. Havel Lecture, Deuel Conference, Los Angeles, California
2012 Doctor Honoris Causa, Bahcesehir University, Istanbul, Turkey
2012 Charles Hollenberg Memorial Lecture, Banting & Best Diabetes Center, Toronto, Canada
2012 İhsan Doğramacı Memorial Lecture and Symposium, Bilkent Un., Ankara, Turkey
2013 Organizer, Keystone Meeting Autophagy, Inflammation and Immunity, Montreal Canada
2013 Member of the Board of Trustees of Kadir Has University, Istanbul
2013 Koc Foundation Science Award
2013 Jean-Pierre Benhamou State-of-the-Art Lecture of EASL, Amsterdam, The Netherlands
2014 Danone Institute International Prize for Nutrition
2014 Sabri Ülker Center for Metabolic Research Directorship
2015 Roy O. Greep Award for Outstanding Research, Endocrine Society
2015 Distinguished Service Award, Society of Inflammation, Miami Winter Sessions


School Committees:
Dean’s Academic Council 2010-present
Chair, Standing Committee on Appointments, Reappointments & Promotions 2009-2011
Member, Executive Committee of Division of Biological Sciences, HSPH 2003-present
Member, Standing Committee on Appointments, Reappointments & Promotions

Chair, Armen Tashjian Award Committee in Excellence in Endocrine Research



Chair, Distinguished Seminar Series in the Division of Biological Sciences 2007-present
Director, John Little Center for Genes and Environment Studies 2008-2012
Chair, Genes and the Environment Steering Committee 2008-2010
Chair, Genes and the Environment Initiative at HSPH 2008-2010
Member, Faculty Search Committee, Cancer Cell Biology, HSPH 1997-1999
Chair, HSPH-BPH Graduate Program Retreat Committee 1997-2000
Chair, Committee for Edgar Haber Memorial Award 1998-2000
Member, BPH Graduate Program Admissions Committee 1999-2004
Chair, PhD in Biological Sciences at HSPH, Qualifying Exam and Advisory Committee 1999
Member, Division of Biological Sciences Strategic Planning Committee 2002-2003
Chair, Faculty Search Committee, Genetics and Complex Diseases 2003-2005
Member, Executive Committee, Genetics and Complex Diseases Roadmap Fellowship Program 2005-present
Member, Faculty Search Committee, Environmental Epigenetics 2008-2009
Member, ad hoc Committee on Faculty Roles, Titles and Responsibilities 2011-2012
Member, MPH Public Health Pilot Course Advisory Board Committee 2015-present
University Committees:  
Member, Harvard Committee for Recommendations on Material Transfers 1996-1999
Member, Clinical Nutrition Research Center at Harvard 1996-present
Member, Harvard University Committee on Patents and Copyrights 2000-2001
Member, Harvard Provost Advisory Group on Science 2002
Member, Harvard Allston Campus Planning Committee 2004
Associate Member, Harvard Stem Cell Institute 2006-present
Member, Harvard Un. Planning Committee for Science & Engineering 2006
Associate Member, Harvard-MIT Broad Institute 2007-present
Member, Harvard Human Genetics Advisory Committee 2007-2008
Member, University Committee on Biological Sciences

Member, New Curriculum Committee for MPH degrees


Member, Search Committee for Professor of Genetics at MGH/HMS 2009
Ad hoc member, Professorial Promotion Committee at HMS 2010
Member, Professorial Promotion Committee of Massachusetts General Hospital 2009
Member, Professorial Promotion Committee of Beth Israel Deaconess Medical Center 2010
Professional Promotion Committee of the Children’s Hospital, Boston and HMS 2011
Member, Harvard-Pfizer Joint Steering Committee 2011-present
Adjunct Investigator, Joslin Diabetes Center 2010-present
Member, Steering Committee for Laboratory for Innovative Translational Technologies, Harvard Catalyst 2012-present
Chair, Professorial Promotion Committee, Dept. Immunology & Infectious Dis. 2012
Chair, Professorial Promotion Committee, Dept. Immunology & Infectious Dis. 2013
Member, Dean’s Search Committee 2015

External Committees/Services:

Member, Boston Obesity Nutrition Research Ctr. of Boston Medical Ctr. 1996-present
Member, Boston Area Diabetes Endocrinology Research Center of MGH 1998-present
Member, External Advisory Board of the Columbia DERC 2006-present
Chair, 13th EASD/JDRF Oxford Workshop “Inflammation, Islets, & Immunity” 2008
Program Committee, International Diabetes Federation 20th World Congress 2008
Medical Science Review Committee, JDRF International 2008
Member, JDRF International Board of Advisors 2008-present
European Research Council, Advanced Research Grant Panel 2008-present
Member, NIH Diabetes Mellitus Interagency Coordinating Committee 2008-present
Member, Review Committee, University of Massachusetts Medical School 2009-present
Member, Executive Scientific Committee, Institute on Diabetes and Obesity 2009-present
Organizer and Host, Boston Turkish Biologists Colloquium 2010-present
Member, Sabri Ülker Foundation for Nutrition Research Advisory Committee 2014-present
Member, American Diabetes Association Research Grant Review Committee 2015-present
Member, Izmir Biomedicine and Genome Center Scientific Advisory Board 2015-present


Study Sections and Grant Evaluation Committees:

 Wellcome Trust, UK; Diabetes, UK; Comitato Telethon Fondazione Onlus, Italy; Israel Science Foundation; Australian Science Foundation; Dutch Diabetes Research Foundation, and National Institutes of Health, USA; Scientific advisory boards of Lipomics and Syndexa Pharmaceuticals Inc, USA; Chair, JDRF Metabolic Control study section, Ad hoc reviewer for Boston Obesity Nutrition Research Center, European Research Council Advanced Grants, Harvard Clinical Nutrition Research Center, National Institute for Diabetes and Digestive Diseases, Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women’s Hospital Scientific Advisory Board.

International Advisory boards, Selection Committees:

Kadir Has University, Board of Directors and Science Award Jury

Sedat Simavi Medicine Award Jury

Koç Award Jury

Sabri Ülker Nutrition Research Foundation, Board Member

Armen Tashjian Award Committee. Chair

Other service: 

Member of the Scientific Steering Committee of the Program Project (Drs. Yarmush, PI, Toner and Nahmias Co-PIs): Living Cell Arrays for Real Time Functional Genomics.

Editorial Reviewer (in alphabetical order):  

Annals of Medicine, Am. J. Physiol., Cell, Cell Stem Cell, Cell Metabolism, Circulation, Developmental Cell, Diabetes, Diabetologia, Acta Diabetologia, Endocrinology, eLIFE, EMBO Journal, EMBO Molecular Medicine, FASEB J., FEBS Letters, Immunity, Int. J. Obesity, J. Biol. Chem., J. Clin. Endocrin. Metabolism, J. Clin. Invest., J. Lipid Res., Lancet, Molecular Cell, Mol Pharmacology, Nature, Nature Cell Biology, Nature Communications, Nature Genetics, Nature Immunology, Nature Materials, Nature Medicine, New England Journal of Medicine, Obesity Res., PLoS One, PLoS Biology, PLoS Genetics, PLoS Medicine, Proc. Natl. Acad. Sci. USA, Science, Science Signaling, Science Translational Medicine.

Editorial Board Member:

Diabetes, Editorial Board, Associate Editor, 2001-2005

Journal of Clinical Investigation, Editorial Board, 2005-present

Turkish Journal of Biochemistry, and Medical Sciences, 2006-, and 2010-present,

EMBO Molecular Medicine, Editorial Board, 2008-present

Journal of Lipid Research, Editorial Board, 2009-present

Journal of Molecular Medicine, Editorial Board, 2009-present

Science Translational Medicine, Advisory Board, 2010-present

Diabetes, Associate Editor, 2011-present

Adipocyte, Associate Editor, 2011-present

Proc Natl. Acad. Sci. USA, Guest Editor, 2012-2013

Cell Metabolism, Editorial Board, 2011-present

EMBO Molecular Medicine, Senior Editor, 2013-present

TEACHING EXPERIENCE (1995 to present):

Supervisor to Students:

Sung-Joon Lee Alena Yermalovich Jason Fan
Sonya Gonzalez Veronica Leautaud Gökhan Dalgin
Aaron Woolsey Kristin Gerhold Ariane Panzer
Wendy Hernandez Raquel Fucho Ariel White
Ross Smith Defne Arslan Lisa Rickey
Eric Vaillancourt Emily Misch Joshua Blanco
Danielle McLaurin Arielle Bauer Michael Alcala
Aybike Onur Brenna Baccaro Guo Tan
Sanae El Shourbagy Truc Nguyen Jared Mayers
Güneş Parlakgül Ekin Güney Nikki Snyder
Ted Goh Sasha Lee Catherine May


Doris Chacon Burcak Civan Pinar Yesil
Deniz Guler Baris Ercal Melinda Snitow
Derya Shimshek Irem Yarali Renin Hazan
Miguel Roman-Colon Yücel Nalbantoglu Jean Shahriar
Sam Stampfer Tali Warbug Lilly Reneker
Fatih Arslan Kyle Kahveci
Turgay Tekinay Ebru Aykan

 Thesis Advisor:

Haiyan Xu, BPH Scholarship Liza Makowski-Hayes, Markey Judy Tsai, NIH-T32
Kathryn Friedinger, NIH-T32 Sara Vallerie, NIH-F32 Margaret Gregor, Pfitzker Fellow
Khanichi Charles, Prize Fellow Ediz Calay, NIH-T32 Meric Erikci, Merit Awardee
Mustafa Yılmaz, BPH Scholar Lauren Robertson, NIH-T32 Vanessa Byles, NIH-T32 

 Graduate Advisor:

Ludger Scheja, PhD Jaswinder K. Sethi, PhD Qiang Tong, PhD
Vidya Muhammed-Ali, PhD Kazuhisa Maeda, MD, PhD Xenia Hom, MD
Jiro Hirosumi, PhD Gurol Tuncman, MD, PhD Genichi Atsumi, PhD
Cem Z. Gorgun, MD, PhD Qiong Cao, PhD Haiming Cao, PhD
Ebru Erbay, MD, PhD Keita Kono, PhD June Cao, PhD
Liza Makowski, PhD Masato Furahashi, MD, PhD Lale Ozcan, MD
Carlos Morgan, PhD Erkan Yilmaz, PhD Umut Ozcan, MD
Ping Li, MD, PhD Takahisa Nakamura, PhD Ling Yang, PhD
Abdullah Yalcin, PhD Suneng Fu, PhD Henrik ten Freyhaus, MD
Sarah Hummasti, PhD Feyza Engin, PhD Motohiro Sekiya, MD, PhD
Amir Tirosh, MD, PhD Ana Paula Arruda, PhD Scott Widenmaier, PhD
Nimet Maherali, PhD Alessandro Arduini, PhD Yankun Li, PhD
Karen Inouye, PhD Furkan Burak, MD Benedicte Mengel, PhD
Alexander Bartelt, PhD Chih-Sheng Yang, PhD Andrea Caricilli, PhD
Kacey Prentice, PhD Min-Dian Li, PhD Benjamin Garfinkel, MD
Renata Golcalves, PhD Ekin Güney, MD Güneş Parlakgül, MD

Career Development Mentor:

Amir Tirosh, MD, PhD Endocrine Fellowship, KO8 Role of the Gap Junction Proteins in Adaptation to ER Stress, and Obesity
Vyacheslav Labunsky, PhD NIH-K99 ER Thiol Redox State and Unfolded Protein Response in Aging
Lydia Lynch, PhD NIH-K08 The role of adipose tissue iNKT cells in regulating metabolism
Takahisha Nakamura, PhD AHA Scientist Development Grant Functional Analysis of PKR, JNK, and RISC in Metabolic Inflammation
Erkin Seker Shriners Career Identification of a Transcriptional Basis of Burn–Induced Hypermetabolism
James Lo, MD, PhD NIH-KO8 Regulation of Adipose Inflammation and Metabolic Disease by Adipsin/factor D
Saeidi Nima, PhD NIH-F32/K99 The Role of Adipose Tissue Remodeling in Surgically-Induced Weight Loss
Omer Yilmaz, MD, PhD NIH-K99 Obesity and Intestinal Cell Stem Function
Alissa Myrick, PhD Yerby Career Development Fellowship Mechanisms and Prevention Strategies for Malaria
Abhinav Bhushan, PhD K99 Using Living Cell Array Microfluidic Platforms to Study Hypermetabolism
Nima Saeidi, PhD NIH-R01 White Adipocytes-Immune Cells Cross Talk Mediates the Sustained Weight Loss Following RYGB
Matthew Lynes, PhD NIH-K01 Studying the in vivo and in vitro effects of the lipokine

Dissertation Advisory/Exam Committees:

Chun-Yu Chin Kendrin Sonnenville
Xun Wang Shannon Reilly
Rory Geyer Diane Gilbert-Diamond
Nat Otoo Edward Ruiz
Laura McLaughlin Prerna Bhargava
Jennifer Falbe Jessica Lucas
Li Ye Jordan Gallinetti
Kutay Karatepe Rama Mwiru
Jennifer Falbe Erin Richman
Nana Keum Bryan O’Sullivan-Murphy
Sihao Liu Nelson Knudsen
Juan Wu Anthony Covarrubias
Lijan Wang Jani Saksi

Course Instructor at Harvard School of Public Health:

Lecturer 1995- BPH 219/DBS205, Seminars in Biological Sciences
Lecturer 1996- HSPH 202CD, The Science of Human Nutrition
Director 1997- HSPH 204CD/ID512, Mol. Mech. of Nutritional and Metabolic Diseases
Lecturer 2012- HSPH LS120, Global Threats to Health


As of Jan. 2015:

Total citations >40,000

Citations/paper : 200

h-factor : 83

Original Articles:
  1. Hotamisligil GS. Proteus syndrome and neurofibromatosis.  Neurofibromatosis 1989, 2:339-240.
  2. Hotamisligil GS and Ertogan F. The Proteus syndrome: association with nephrogenic diabetes insipidus. Clin Genet 1990, 38:139-144.
  3. Chen Z-Y, Hotamisligil GS, Huang JK, Wen L, Ezzeddine DZ, Aydin-Muderrisoglu N, Powell JF, Huang RH, Breakefield XO, Craig I, Hsu Y-PP. Structure of the human gene for monoamine oxidase type A.  Nucl Acid Res 1991, 19:4537-4541.
  1. Hotamisligil GS and Breakefield XO. Human monoamine oxidase A gene determines levels of enzyme activity.  Am J Hum Genet 1991, 49:383-392.
  1. Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL, Breakefield XO.  Relationship between platelet monoamine oxidase B activity and alleles at the MAOB       locus.  J Neurochem 1992, 59:2063-2066.
  1. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance.  Science 1993, 259:87-91.
  1. Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity and TNF-a.  Cell 1993, 73:625-627.
  1. Hotamisligil GS, Girmen AS, Fink S, Tivol E, Shalish C, Tofatter J, Baenziger J, Diamond S, Markham C, Sullivan J, Growdon J, Breakefield XO. Hereditary variations in monoamine oxidase as a risk factor for Parkinson’s disease.  Movement Disorders 1994, 9:305-310.
  1. Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for TNF-a and its receptors during drug and dietary modulation of insulin resistance.  Endocrinology 1994, 134:264-270.
  1. Hotamisligil GS, Budavari A, Murray DL, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-a. J Clin Invest 1994, 94:1543-1549.
  1. Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor-a inhibits signaling from the insulin receptor. Proc Natl Acad Sci USA 1994, 91:4854-4858.
  1. Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of TNF-a in human obesity and insulin resistance.  J Clin Invest 1995, 95:2409-2415.
  1. Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor-a inhibits insulin signaling through stimulation of p55 TNF receptor and activation of sphingomyelinase.  J Biol Chem 1996, 271:13018-13022.
  1. Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.  Science 1996, 274:1377-1379.
  1. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNFa and obesity-induced insulin resistance. Science 1996, 271:665-668.
  1. Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes 1997, 46:451-455.
  1. Kirchgessner TG, Uysal KT, Weisbrock S, Marino M, Hotamisligil GS. Tumor necrosis factor-a contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.  J Clin Invest 1997, 100:2777-2782.
  1. Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-a  Nature 1997, 389:610-614.
  1. Uysal KT, Wiesbrock SM, Hotamisligil GS. Functional analysis of TNF receptors in TNF-a-mediated insulin resistance in genetic obesity. Endocrinology 1998, 139:4832-4838.
  1. Chu N-F, Makowski L, Hotamisligil GS, Rimm EB. Stability of human plasma leptin concentrations within 36 hours following specimen collection.  J Clin Biochem 1999, 32:87-89.
  1. Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ. Tumor necrosis factor-a is a key component in the obesity-linked elevation of plasminogen activator inhibitor-1.  Proc Natl Acad Sci USA 1999, 96:6902-6907.
  1. Scheja L, Makowski L, Uysal KT, Wiesbrock SM, Shimshek D, Parker RA Hotamisligil GS. Altered insulin secretion associated with reduced lipolytic efficiency in aP2-deficient mice.  Diabetes 1999, 48:1987-1994.
  1. Xu H, Sethi JK, Hotamisligil GS. Transmembrane tumor necrosis factor (TNF-a) inhibits adipocyte differentiation by selectively activating TNF receptor 1.  J Biol Chem 1999, 274:26287-26295.
  1. Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNF-a functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Letters 2000, 469:77-82.
  1. Memon RA, Hotamisligil GS, Wiesbrock SM, Uysal KT, Faggioni R, Moser AH, Feingold KR, Grunfeld C. Upregulation of uncoupling protein 2 mRNA in genetic obesity: lack of an essential role from leptin, hyperphagia, increased tissue lipid content, and TNF-a.  Biochem Biophys Acta 2000, 1484:41-50.
  1. Nisoli E, Briscini L, Giordano A, Tonello C, Wiesbrock SM, Uysal KT, Cinti S, Carruba MO, Hotamisligil GS. Tumor necrosis factor-a mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity. Proc Natl Acad Sci USA 2000, 97:8033-38.
  1. Chu, NF, Spiegelman D, Rifai, N, Hotamisligil GS, Rimm EB. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal and overweight US men.  Int J Obes Relat Metab Disord 2000, 24:1085-1092.
  1. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2.  Endocrinology 2000, 141:3388-3396.
  1. Tong Q, Dalgin G, Xu  H, Ting  C-N, Leiden  JM, Hotamisligil GS.  Function of GATA transcription factors in preadipocyte-adipocyte transition.  Science 2000, 290:134-138.
  1. Chu NF, Stampfer MJ, Spiegelman D, Rifai N, Hotamisligil GS, Rimm EB. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. Int J Obesity 2001, 25:106-114.
  1. Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker R, Suttles J, Fazio S, Hotamisligil GS, Linton MF. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nature Medicine 2001, 7:699-705.
  1. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Stampfer M, Rimm EB. Plasma insulin, leptin, and soluble TNF receptor levels in relation to atherogenic and thrombogenic cardiovascular disease risk factors among men.  Atherosclerosis 2001, 157:495-503.
  1. Chu NF, Spiegelman D, Hotamisligil GS, Rifai N, Rimm EB. Plasma leptin concentrations and 4-year weight gain among US men. Int J Obesity 2001, 25:346-353.
  1. Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS. Adipose tissue resistin expression is severely suppressed in obesity and stimulated by PPARg  J Biol Chem 2001, 276:25651-25653.
  1. Xu H and Hotamisligil GS. Signaling pathways utilized by tumor necrosis factor receptor 1 in adipocytes to suppress differentiation. FEBS Letters 2001, 506:97-102.
  1. Fisher RM, Eriksson P, Hoffstedt J, Hotamisligil GS, Thorne A, Ryden M, Hamsten A, Arner P. Fatty acid binding protein expression in different human adipose tissue depots from lean and obese individuals. Diabetologia 2001, 44:1268-1273.
  1. Mohamed-Ali V, Flower L, Sethi J, Hotamisligil GS, Gray R, Humphries SE, York DA, Pinkney J. ß-adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro  J Clin Endocrinol Metab 2001, 86:5864-5869.
  1. Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van Obberghen E. SOCS-3 inhibits insulin signaling and is up-regulated in response to TNF-a in the adipose tissue of obese mice.  J Biol Chem 2001, 276:47944-47949.
  1. Chiellini C, Bertacca A, Gorgun CZ, Ciccarone A, Giordano A, Xu H, Soukas A, Costa M, Gandini D, Dimitri R, Bottone P, Cecchetti P, Pardini E, Perego L, Navalesi R, Folli F, Benzi L, Cinti S, Friedman JM, Hotamisligil GS, Maffei M. Obesity modulates the expression of haptoglobulin in white adipose tissue via TNF-a. J Cell Physiol 2002, 190:251-258.
  1. Fisher RM, Hoffstedt J, Hotamisligil GS, Thorne A, Ryden M. Effects of obesity and weight loss on the expression of proteins involved in fatty acid metabolism in human adipose tissue. Intl J Obes Relat Metab Disord 2002, 26:1379-1385.
  1. Xu H, Hirosumi J, Uysal KT, Guler AD, Hotamisligil GS. Exclusive action of transmembrane TNF-a in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance. Endocrinology 2002, 143:502-511.
  1. Xu H, Uysal KT, Becherer D, Arner P, Hotamisligil GS. Altered tumor necrosis factor-a (TNF-a) processing in adipocytes and increased expression of transmembrane TNF-a in obesity. Diabetes 2002, 51:1876-1883.
  1. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Adipocyte fatty acid binding protein, aP2, alters later atherosclerotic lesion formation in severe hypercholesterolemia. Art Thro Vasc Bio 2002, 22:1686-1691.
  1. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS. A central role for JNK in obesity and insulin resistance.  Nature 2002, 420:333-336.
  1. Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. Role of the fatty acid-binding protein mal1 in obesity and insulin resistance. Diabetes 2003, 52:300-307.
  1. Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 & p75 TNF-a receptors in the induction of plasminogen activator inhibitor-1. Am J Phys 2003, 162:933-941.
  1. Pischon T, Hotamisligil GS, Rimm EB. Adiponectin: stability in plasma over 36 hours and within-person variation over 1 year. J Clin Biochem 2003, 49:650-652.
  1. Tong Q, Sankalé J-L, Hadigan CM, Tan G, Rosenberg ES, Kanki PJ, Grinspoon SK, Hotamisligil GS. Regulation of adiponectin in human immunodeficincy virus infected patients: relationship to body composition and metabolic indices. J Clin Endocrinol Metabol 2003, 88:1559-1564.
  1. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB. Habitual dietary intake of n-3 and n-6-fatty acids in relation to inflammatory markers among US men and women.  Circulation 2003, 108:155-160.
  1. Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB. Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 2003, 11:1055-1064.
  1. Pischon T, Girman C, Hotamisligil GS, Rifai N, Hu FB, Rimm E. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004, 291:1730-1737.
  1. Wellen KE, Uysal KT, Wiesbrock S, Yang Q, Chen H, Hotamisligil GS. Interaction of TNF-a and thiazolidinedione-regulated pathways in obesity.  Endocrinology 2004,145:2214-2220.
  1. Boord JB, Maeda K, Makowski L, Babaev VR, Fazio S, Linton MF, Hotamisligil GS. Combined fatty acid-binding protein deficiency improves metabolism, reduces atherosclerosis, and increases survival in apolipoprotein E-deficient mice.  Circulation 2004, 110:1492-1498.
  1. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Glimcher L, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.  Science 2004, 306:457-461.
  1. Pischon T, Girman CJ, Rifai N, Hotamisligil GS, Rimm EB. Association between dietary factors and plasma adiponectin concentration in men.  Am J Clin Nutr 2005, 81:780-786.
  1. Tong Q, Tsai J, Tan G, Dalgin G, Hotamisligil GS. Interaction between GATA and C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.  Mol Cell Bio 2005, 25:706-715.
  1. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes.  J Clin Invest 2005, 115:1111-1119.
  1. Makowski L, Brittingham KC, Reynolds JM, Suttles J, Hotamisligil GS. The fatty acid- binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. J Biol Chem 2005, 280:12888-12895.
  1. Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metabolism 2005, 1:107-119.
  1. Tsai J, Tong Q, Tan G, Chang AN, Orkin SH, Hotamisligil GS. The transcription factor GATA2 regulates differentiation of brown adipocytes.  EMBO Reports 2005, 6:879-884.
  1. Neels JG, Pandey M, Hotamisligil GS, Samad F. Autoamplification of tumor necrosis factor-alpha: a potential mechanism for the maintenance of elevated tumor necrosis factor-alpha in male but not female obese mice. Am J Pathol 2006, 168:435-444.
  1. Sankale J-LG, Tong Q, Hadigan CM, Tan G, Grinspoon SK, Kanki PJ, Hotamisligil GS. Regulation of adiponectin in adipocytes upon exposure to HIV-1. HIV Medicine 2006, 7:268-274.
  1. Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Tobe K, Kadowaki T, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Bruning JC. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metabolism, 2006, 3:247-256.
  1. Tuncman G, Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. Proc Natl Acad Sci USA 2006, 103:6970-6975.
  1. Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci USA 2006, 103:10741-10746.
  1. Cao H, Maeda K, Gorgun CZ, Kim HJ, Park SY, Shulman GI, Kim JK, Hotamisligil GS. Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-deficient mice. Diabetes 2006, 55:1915-1922.
  1. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nature Medicine 2006, 12:917-924.
  1. Shum B, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS. The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation. J Clin Invest 2006, 116:2183-2192.
  1. Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear JL. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem Biophys Res Commun 2006, 350:1063-1068.
  1. Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
  1. Rolph MS, Young TR, Shum BO, Gorgun CZ, Schmitz-Peiffer C, Ramshaw IA, Hotamisligil GS, Mackay CR. Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein aP2. J Immunol 2006, 177:7794-801
  1. Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE. Tumor necrosis factor-a and induced skeletal muscle insulin resistance involves the suppression of AMP-kinase signaling. Cell Metabolism 2006, 4:465-474.
  1. Song Y, Manson JE, Tinker L, Rifai N, Cook NR, Hu FB, Hotamisligil GS, Ridker PM, Rodriguez BL, Margolis KL, Oberman A, Liu S. Circulating levels of endothelial adhesion molecules and risk of diabetes mellitus in an ethnically diverse cohort of women.  Diabetes 2007, 56:1898-18904.
  1. Hotamisligil GS. Inflammation and metabolic disorders.  Nature 2006, 444:860-867.
  1. Wellen K, Fucho R, Gregor MF, Furuhashi M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F, Hotamisligil GS. Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis. Cell 2007, 129:537-548.
  1. Furuhashi M, Tuncman G, Gorgun CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS. Treatment of diabetes and atherosclerosis by inhibiting fatty acid-binding protein aP2. Nature 2007, 447:959-965.
  1. Reynolds JM, Liu Q, Brittingham KC, Liu Y, Gruenthal M, Gorgun CZ, Hotamisligil GS, Stout RD, Suttles J. Deficiency of fatty acid-binding proteins in mice confers protection from development of experimental autoimmune encephalomyelitis.  J Immunol 2007, 179:313-321.
  1. Liu S, Tinker L, Song Y, Rifai N, Bonds D, Cook NR, Heiss G, Howard B, Hotamisligil GS, Hu FB, Kuller L, Manson JE. A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Arch Int Med 2007, 167:1676-1685.
  1. Ozcan U, Ozcan L, Yilmaz E, Duvel K, Sahin M, Manning BD, Hotamisligil GS. Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.  Mol Cell 2008, 29:541-551.
  1. Furuhashi M, Fucho R, Gorgun C, Tuncman G, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes. J Clin Invest 2008, 118:2640-2650.
  1. Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role of JNK activity in the stromal elements in regulating systemic insulin sensitivity.  PLoS One 2008 3:1-11.
  1. Cao H, Gerhold K, Wiest MW, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008, 134:933-944.
  1. Gregor MF, Yang L, Fabbrini E, Mohammed BS, Eagon JC, Hotamisligil GS, Klein S. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009, 58:693-700.
  1. Chavey C, Lazennec G, Lagarrigue S, Clapé1 C, Iankoval I, Teyssier J, Annicotte J-S, Schmidt J, Mataki C, Yamamoto H, Sanches R, Guma A, Stich V, Vitkova M, Jardin-Watelet B, Renard E, Strieter R, Tuthill A, Hotamisligil GS, Vidal-Puig T, Zorzano A, Langin D, Fajas L. CXCL5 is an adipose tissue derived factor that links obesity to insulin resistance. Cell Metabolism 2009, 4:339-349. 
  1. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi G-P. Deficiency and pharmacological stabilization of mast cells reduces diet-induced obesity and diabetes in mice. Nature Medicine 2009, 8:940-945.
  1. Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow M, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nature Medicine 2009, 12:1383-91.
  1. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348.
  1. Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity causes insulin resistance. Cell Metabolism 2010, 11:467-478.
  1. Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S. Tauroursodeoxycholic acid improves may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 2010, 59:1899-1905.
  1. Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.  Am J Clin Nutr 2010, 92:1350-8.
  1. Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in US Adults.Ann Intern Med 2010, 153:790-9.
  1. Babaev VR, Runner RP; Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün CZ, Fazio S, Hotamisligil GS; Linton MF. Macrophage mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-{gamma}-regulated genes. Arterioscler Thromb Vasc Biol 2011, 6:1283-90.
  1. Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
  1. Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH. Dual and opposing roles of the unfolded protein response regulated by IRE1alpha and XBP1 in proinsulin processing and insulin secretion. Proc Natl Acad Sci USA 2011, 108:8885-90.
  1. Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Cell Metabolism 2011, 14:21-32.
  1. Fu S, Yang L, Li P, Hoffman O, Dicker L, Hide W, Lin X, Watkins, SM, Ivanov A, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver ER stress in obesity. Nature 2011, 473: 528-531.
  1. Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nature Medicine 2011, 17:1498-503.
  1. Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 2011, 6;14(1):21-32.
  1. Furuhashi M, Ishimura S, Ota H, Hayashi M, Nishitani T, Tanaka M, Yoshida H, Shimamoto K, Hotamisligil GS, Miura T. Serum fatty acid-binding protein 4 is a predictor of cardiovascular events in end-stage renal disease. PLoS One 2011; 6(11).
  1. Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A. The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatology 2012, 56:952-64.
  1. Oh RS, Pan W, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. Functional RNA interference (RNAi) screen identifies system a neutral amino acid transporter 2 as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem 2012, 287:6025-34.
  1. Fu S, Watkins SM, Hotamisligil GS. The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metabolism 2012, 15:623-34.
  1. Fukuda D, Aikawa E, Swirski FK, Novobrantseva T, Kotelianski V, Gorgun CZ Chudnovskiy A, Yamazaki H, Croce K, Weissleder R, Aster JC, Hotamisligil GS, Yagita H, Aikawa M. Notch ligand delta-like 4 blockade attenuates atherosclerosis and metabolic disorders. Proc Natl Acad Sci USA 2012, 109:E1868-77.
  1. ten Freyhaus H, Calay ES, Yalcin A, Vallerie SN, Yang L, Calay ZZ, Saatcioglu F, Hotamisligil GS. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metabolism 2012, 16:81-9.
  1. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil GS, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis 2012, 15:457-68.
  1. Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Tiny JPY, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammosme activation and HMGB1 release. Nature 2012, 488:670-4.
  1. Watkins SM, Hotamisligil GS. Promoting atherosclerosis in type 1 diabetes through the selective activation of arachidonic acid and PGE2 production. Circ Res 2012, 111:394-6.
  1. Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS. Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting. PLoS Genetics 2012, 8(8):e1002902.
  1. Ghelfi E, Yu C, Elmasri H, Terwelp M, Lee CG, Bhandari V, Comhair S, Erzurum S, Hotamisligil GS, Elias JA, Cataltepe S. Fatty acid binding protein 4 regulates VEGF-induced airway angiogenesis and inflammation in a transgenic mouse model; implications for asthma. Am J Pathol 2013, 182(4):1425-33.
  1. Mozzafarian D, Lemaitre RN, de Oliveira Otto MC, Fretts AM, Hotamisligil GS, Tsai MY, Siscovick DS, Nettleton JA. Trans-Palmitoleic acid, other dairy fat biomarkers and incident diabetes: the multi-ethnic study of atherosclerosis (MESA). Am J Clin Nutr 2013, 97(4):854-61.
  1. Yalcin A, Hotamisligil GS. Impact of ER protein homeostasis on metabolism. Diabetes 2013, 62(3):691-3.
  1. Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep 2013, 3(5):1430-9.
  1. Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metabolism 2013, 17(5):768-78.
  1. Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MR, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, HotamisligilGS, Kurabayashi M.  Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.  Thromb Vasc. Biol 2013, (11):2549-57.
  1. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelia A, Plutzky J, Lee C. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization. Nature 502(7472):550-4.
  1. Rizky M, Syamsunarno AA, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systematic response to fasting. PLoS One 2013, 14;8(11). 
  1. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 2013, 502(7472):550-4.
  1. Engin F, Yermalovich A, Nguyen T, Hummasti S, Fu W, Eizirik DL, Mathis D, Hotamisligil GS. Restoration of the unfolded protein response in pancreatic β cells protects mice against type 1 diabetes. Science Transl Med 2013, 13;5(211).
  1. Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, YoshitoTsushima, Endo K, Hotamisligil GS, Kurabayashi M. A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. PLoS One 2013, 14;8(11).
  1. Zhang Y, Nicholatos J, Dreier JR, Ricoult SJ, Widenmaier SB, Hotamisligil GS, Kwiatkowski DJ, Manning BD. Coordinated regulation of protein synthesis and degradation by mTORC1. Nature 2014, 18;513(7518):440-3.
  1. Nakamura T, Furuhashi M, Baccaro B, Hotamisligil GS. Small-molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes 2014, 63(2):526-34.
  1. Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S. Fatty acid binding protein 4 deficiency protects against oxygen-induced retinopathy in mice. PloS One 2014, 6;9(5):e96253.
  1. Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M. FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.  Diabetes 2014, 63(3):900-911.
  1. Engin F, Nguyen T, Yermalovich A, Hotamisligil GS. Aberrant islet unfolded protein response in type 2 diabetes. Scientific Reports 2014, 11;4:4054.
  1. Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum—mitochondria contact leads to mitochondrial dysfunction in obesity. Nature Medicine 2014, 20(12):1427-35.
  1. Erikci Ertunc M, Sikkeland J, Fenaroli F, Griffiths G, Daniels MP, Cao H, Saatcioglu F, Hotamisligil GS. Secretion of fatty acid binding protein aP2 from adipocytes through a non-classical pathway in response to adipocyte lipase activity. J Lipid Res 2015, 56(2):423-34.
  1. Lindstad T, Sikkeland J, Dezitter X, Qu S, Muhumed RM, Erikci Ertunc M, Gregor MF, Hotamisligil GS, Saatcioglu F. ER stress downregulates STAMP2 expression in adipocytes by disruption of C/EBPα promoter recruitment. Embo Mol Med, [In Press].
  1. Nakamura T, Kunz RC, Zhang C, Kimura T, Yuan CL, Baccaro B, Namiki Y, Gygi SP, Hotamisligil GS. A critical role for PKR complexes with TRBP in immunometabolic regulation and eIF2a phosphorylation in obesity. Cell Reports 2015, 14;11(2):295-307.
  1. Youssef OA, Safran S, Nakamura T, Nix DA, Hotamisligil GS, Bass BL. Potential role for snoRNAs in PKR activation during metabolic Stress. Proc Natl Acad Sci USA
  1. Fu S, Yalcin A, Lee GY, Li P, Fan J, Arruda AP, Pers BM, Yilmaz M, Eguchi K, Hotamisligil GS. Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Science Translational Medicine 2015, 17;7(292):292ra98.
  1. Yang L, Calay E, Fan J, Arduini A, Kunz RC, Gygi SP, Yalcin A, Fu S, Hotamisligil GS. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction. Science 2015, 349(6247):500-6.
  1. Arruda A, Hotamisligil GS. Calcium homeostasis and organelle function in the pathogenesis of obesity and diabetes. Cell Metabolism 2015, 1;22(3):381-97.
  1. Burak FM, Inouye K, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Science Translational Medicine 2015, 7(319):319ra205.
  2. Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Long-term calorie restriction enhances cellular quality-control processes in human skeletal muscle. Cell Reports 2016, 14(3):422-428. 


Books, Chapters, and Commentaries:
  1. Hotamisligil GS. Proteus syndrome and neurofibromatosis. Neurofibromatosis 1989, 2:339-340.
  1. Hotamisligil GS. Proteus syndrome and hamartoses with overgrowth. Dysmorphol Clin Genet 1990, 4:87-102.
  1. Spiegelman BM, Choy LN, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes.  J Biol Chem 1993, 268:6823-6826.
  1. Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF-a. Cell 1993, 73:625-627.
  1. Hotamisligil GS, Spiegelman BM. TNF-a: a key component of the obesity-diabetes link. Diabetes 1994, 43:1271-1278.
  1. Hotamisligil GS, Peraldi P, Spiegelman BM. The molecular link between obesity and diabetes. Curr Opin Endocrinol Diabetes 1996, 16-23.
  1. Hotamisligil GS, Spiegelman BM. Mechanisms of TNF-a-mediated insulin resistance: inhibition of insulin receptor tyrosine kinase. Molecular and Genetic Aspects of Obesity: Bray GA, Ryan DH, eds., Louisiana State Un. Press, Baton Rouge, 1996, 205-216.
  1. Hotamisligil GS, Spiegelman BM. TNF-a and the insulin resistance of obesity. Diabetes Mellitus: LeRoith D, Taylor SI, Olefsky JM, eds., Lippincott-Raven Publishers, Philadelphia, 1993, 554-560.
  1. Hotamisligil GS. The cross-talk between insulin and tumor necrosis factor receptors in insulin resistance. Endocrinol Metabol 1997, 4:151-153.
  1. Hotamisligil GS. Mechanisms of TNF-a-induced insulin resistance. Exp Clin Endocrinol Diabetes 1999, 107:119-125.
  1. Hotamisligil GS. The role of TNF-a and TNF receptors in obesity and insulin resistance. J Intern Med 1999, 245:621-625.
  1. Sethi JK, Hotamisligil GS. The role of TNF-a in adipocyte metabolism. Cell Development Biology 1999, 10:19-29.
  1. Hotamisligil GS, Spiegelman BM. TNFa and the insulin resistance of obesity. Diabetes Mellitus: a fundamental and clinical text.  LeRoith D, Taylor SI, Olefsky JM, eds., Lippincott-Raven Publishers, Philadelphia, 2000, 651-659.
  1. Hotamisligil GS. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes 2000, Suppl 4:S23-7.
  1. Tong Q, Hotamisligil GS. Molecular mechanisms of adipocyte differentiation. Reviews in Endocrine Met Disorders 2001, 2:349-355.
  1. Abumrad NA, Hotamisligil GS. Command centers for metabolic control can be in the most unexpected places. Curr Opin Clin Nutr Metab Care 2002, 5:357-358.
  1. Hotamisligil GS. Inflammation, tumor necrosis factor-a, and insulin resistance. In LeRoith, D, Taylor SI, Olefsky, JM, eds.  In Diabetes Mellitus: a fundamental and clinical text.  3rd Philadelphia: Lippincott Williams & Wilkins, 2003, Chapter 64:953-962.
  1. Hotamisligil GS. The irresistible biology of resistin. J Clin Invest 2003, 111:173-174.
  1. Tong Q, Tsai J, Hotamisligil GS. GATA Transcription factors and fat cell formation.  Drug News & Perspectives 2003, 16:585-588.
  1. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest, 2003, 112:1785-1788.
  1. Hotamisligil GS. Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 2003, Suppl. 3:S53-55.
  1. Makowski L, Hotamisligil GS. Fatty acid-binding proteins- the evolutionary crossroads of inflammatory and metabolic responses.  J of Nutrition 2004, 134(9):2464S-68S.
  1. Makowski L, Hotamisligil GS. The role of fatty acid-binding proteins in atherosclerosis.  Curr Opin Lipidology 2005, 16:543-548.
  1. Tsai J, Tong Q, Hotamisligil GS. GATA proteins as molecular gatekeepers of adipogenesis.  In New Transcription Factors and their Roles in Diabetes and its Therapy: Friedman, J.E., eds., Elsevier Science B.V. Publishers, 2006.
  1. Hotamisligil GS. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes.  Diabetes 2005, 54:S73-S78.
  1. Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006, 131:934-945.
  1. Tong Q, Hotamisligil GS. Cell fate in the mammary gland.  Nature 2007, 445:724-726.
  1. Gregor MF, Hotamisligil GS. Adipocyte stress: the endoplasmic reticulum and metabolic disease. J Lipid Res 2007, 48:1905-1914.
  1. Erbay E, Cao H, Hotamisligil GS. Adipocyte/macrophage fatty acid-binding proteins in metabolic syndrome.  Curr Atheroscler Rep 2007, 9:222-229.
  1. Furuhashi M, Hotamisligil GS. Regulation of metabolic homeostasis through a family of fatty acid-binding proteins.  Nature Rev Drug Discov 2008, 7:489-503.
  1. Erbay E, Hotamisligil GS. Nutrient sensing and inflammation in metabolic diseases.  Nature     Rev Immunol 2008, 8:923-934.
  1. Yang L, Hotamisligil GS. Stressing the brain, fattening the body. Cell 2008, 135:20-22.
  1. Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes 2008, S52-S54.
  1. Hotamisligil GS. Endoplasmic reticulum stress and atherosclerosis. Nature Medicine 2010, 16:396-399.
  1. Li P, Hotamisligil GS. Host and microbes in a pickle. Nature 2010, 464:1287-88.
  1. Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 2010, 107: 579-591.
  1. Engin F, Hotamisligil GS. Restoring ER function by chemical chaperones: An emerging therapeutic approach for metabolic diseases.  Diabetes, Obesity and Metabolism 2010, 12(2): 108-113.
  1. Vallerie SN and Hotamisligil GS. The role of JNK proteins in metabolism. Science Transl Med 2010, 1;2(60):60rv5.
  1. Gregor M, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2010, 17:30.
  1. Horng T, Hotamisligil GS. Linking the inflammasome to obesity-related disease. Nature Medicine 2011, 17:164–165.
  1. Erbay E, Hotamisligil GS. Inflammatory causes of obesity and metabolic diseases. In Epidemiology, Etiology, and Physiopathology CRC Press, Chapter 52:573-590.
  1. Hotamisligil GS, Davis RJ. Cell signaling and stress responses.  In Signal Transduction; Principles, Pathways, and Processes Cold Spring Harbor Laboratory Press, Chapter 18:345-364.
  1. Yilmaz M, Hotamisligil GS. Damned if you do, damned if you don’t: the conundrum of adipose tissue vascularization. Cell Metab 2013, 17(1):7-9.
  1. Yalcin A, Hotamisligil GS. Impact of endoplasmic reticulum protein homeostasis on metabolism. Diabetes 2013, 62(3):691-3.
  1. Calay ES, Hotamisligil GS. Turning off the inflammatory, but not the metabolic, flames.  Nature Medicine 2013, 19(3):265-7.
  1. Nair KS, Abel SG, DyckPJ, Gardner TW, Haskins KM, Hotamisligil GS, Jensen MD, Krook A, Mandarino LJ, Mitchell BD, Pessin JE, Sowers JR, Sussel L, Wareham N, Vella A. Time to look back and to look forward. Diabetes 2014, 63(4):1169-70.
  1. Erikci Ertunc M, Hotamisligil GS. Lipids in physiology and metaflammation. J Lipid Res [In Press].
  1. Hotamisligil GS. Inflammation and metabolic disorders: a 10-year update. Nature [In Press].
  1. Hotamisligil GS. The birth of immunometabolism: finding links between obesity, insulin resistence and diabetes. Nature Reviews Immunology [In Press].
  1. Yilmaz M, Hotamisligil GS. Bioactive lipids in immunometabolism. Diabetes [In Press].
Invited Lectures:

Local and National:

  • Session Organizer and Plenary Speaker, ADA Annual sessions, New Orleans, June 2016
  • Plenary Lecture, Keystone Symposia, Tuberculosis, Keystone, February 2016.
  • Award Lecturer, 49th Annual Miami Winter Symposium, Miami, FL, January 2016.
  • Award Lecturer, Roy O. Greep Award for Outstanding Research Lecture, 97th Annual Meeting of the Endocrine Society, San Diego, CA, March 2015.
  • Special Guest, President’s Lecture Series, Sanford Burnham Medical Research Institute, San Diego, CA, March 2015.
  • Plenary Lecture, Keystone Symposia J6, Diabetes and Metabolic Dysfunction Symposium, Santa Fe, NM, February 2015.
  • Speaker, National Cancer Institute, UPR in Cancer Development, Washington, DC, June 2014.
  • Keynote Lecturer, Experimental Biology Meeting, San Diego, CA, April 2014.
  • Keynote Lecturer, IDOM & IFI Symposium, University of Pennsylvania, Philadelphia, PA, December 2013.
  • Lecturer, Joslin Symposium Honoring Ronald Kahn, Boston, MA, October 2013.
  • Kenneth Rainin Foundation Innovations Symposium. “Stress Responses, Inflammation and Disease.” Chicago, IL, July 2013.
  • ADA 73rd Scientific Sessions in Chicago, IL, June 2013.
  • Special Guest, Seminar Series. Washington University, St. Louis, April 2013
  • Keystone Symposium on Metabolic Control of Inflammation and Immunity. Beaver Run Resort, Breckinridge, CO, January 2013.
  • Keystone Symposium. (J6) Diabetes – New Insights into Mechanism of Disease and its Treatment. Keystone, CO, January 2013.
  • Keystone Meeting – Mitochondria, Metabolism and Myocardial Function; Basic Advances to Translational Studies. Keystone, CO, January 2013.
  • Revolutionizing Health Science and Technology: From Genes to the Globe. Leadership Council, HSPH, Boston, MA, October 2013.
  • Inaugural Lecture, Cedars Sinai Medical Center, Infectious and Immunological Diseases Research Center, Los Angeles, CA, October 2013.
  • Speaker and Moderator, Boston Biotechnology Convention. Boston Convention & Exhibit Center, Boston, MA, June 2012.
  • Invited Lecture, Methodist Hospital Research Institute, Houston, TX, May 2012.
  • Lipid Maps Annual Meeting, “Lipidomics Impact on Cell Biology, Metabolomics and Translational Medicine”, La Jolla, CA, May 2012
  • The Havel Lecturer, Duel Conference, March 2012, Rancho Las Palmas, CA.
  • Plenary Lecture, Keystone Symposia J7 “Genetic and Molecular Basis of Obesity and Body Weight Regulation”, Santa Fe NM, January 2012.
  • Plenary Lecture, Keystone Symposia D1, “Fibrosis: Translation of Basic Research to Human Disease and Novel Therapeutics”, Blue Sky, MT, March 2012.
  • Keynote Lecture, FASEB Conference, Saxton’s River, VT, June 2011.
  • Brigham and Women’s Hospital “Frontier in Cardiovascular Biology Seminar Series.” Boston, MA, June 2011.
  • Cincinnati Cancer Symposium, Cincinnati, OH, May 2011.
  • JDRF “Role of Beta Cell Antigen Modifications in the Pathogenesis of T1D and their Diagnostic and Therapeutic Potential”, New York, NY, December 2010.
  • Speaker, PEW Scholars 25th Reunion, Duck Key, FL, November 2010.
  • 12th Annual Frontiers in Diabetes Research Meeting, New York, NY, November 2010.
  • 2010 Cold Spring Harbor Laboratory Meeting on Nuclear Receptors & Disease, Long Island, NY, August 2010.
  • American Diabetes Association’s 70th Scientific Sessions, Orlando, FL, June 2010.
  • Plenary Lecture, Endocrine Society Meeting, San Diego, CA, June 2010.
  • Kroc Lecture at the University of Alabama, Birmingham, AL, April 2010.
  • Annual Wyeth Discovery Frontiers in Human Disease, New York, NY, March 2010.
  • Distinguished Lecture Series of Eli Lilly and Company, Indianapolis, IN, February 2010.
  • University of Pennsylvania, Department of Pharmacology, ITMAT Seminar Series, Philadelphia, PA, January 2010.
  • 8th Bi-Annual meeting: International Chair on Cardiometabolic Risk, October 2009, Boston, MA.
  • 4th Annual Frontiers of Clinical Investigation: Bench to Bedside Symposium, La Jolla at Torrey Pines, CA, October 2009.
  • FASEB Summer Research Conference, Saxon’s River, VT, June 2009.
  • Visiting Professor, University of Michigan, Ann Arbor, MI, May 2009.
  • NIH, NIDDK meeting, “Interface Between Metabolic Disturbances and Alterations of the Immune System, Bethesda, MD, May 2009.
  • Endocrine Grand Rounds, Boston University, Boston, MA, February 2009.
  • NIH, NIDDK workshop “Protein Mis-folding and Mis-processing in Disease”, Bethesda, MD, January 2009.
  • Dean’s Distinguished Seminar Series, University Colorado School of Medicine, Aurora, CO, January 2009.
  • Endocrine Grand Rounds, Brigham and Women’s Hospital, Boston, MA, January 2009.
  • Research Affinity Group on Cell and Gene Therapy, Children’s Hospital Philadelphia, Philadelphia, PA, December 2008.
  • Skirball Symposium, Skirball Institute Meeting, NYU, New York, NY, November 2008.
  • Yale University, Depts. of Physiology & Pharmacology Meeting, New Haven, CT, October 2008.
  • Merck Expert Forum, Rahway, NJ, May 2008.
  • Joslin Diabetes Research Center Meeting, Boston, MA, May 2008.
  • Harvard School of Public Health, Department of Nutrition, Boston, MA, April 2008.
  • American Society for Biochemestry and Molecular Biology Annual Meeting, San Diego, CA, April 2008.
  • Endocrine Grand Rounds, Beth Israel Medical Deaconess Center, Boston, MA, March 2008.
  • Molecular and Human Genetics Seminar Series, Baylor College of Medicine, Houston, TX, March 2008.
  • Kroc Scholar Lecture, University of Washington, Seattle, WA, March 2008.
  • Schering Plough Meeting, Rahway, NJ, March 2008.
  • Pennington Biomedical Research Center, Louisiana State University, March 2008, Baton Rouge, LS.
  • Keystone Symposia, January 2008, Breckenridge, CO.
  • Endocrine Grand Rounds, Massachusetts General Hospital, October 2007, Boston, MA.
  • Pfizer Visiting Professorship in Diabetes, UC Davis, October 2007, Davis, CA.
  • Schering Plough Meeting, Cambridge MA, September 2007.
  • Cardiometabolic Health Congress, Boston, MA, September 2007.
  • Invited speaker, Rhode Island Hospital/Brown Medical School, Providence, RI, September 2007.
  • Nathan W. Shock Aging Symposium, National Institutes of Aging Towson, MD, September 2007.
  • Invited speaker, University of Alabama, Birmingham, AL, September 2007.
  • Lilly Lecture, Annual American Diabetes Association meeting, Chicago, IL, June 2007.
  • Massachusetts Dietetic Association, Marlborough, MA, April 2007.
  • Keystone Symposia, Steamboat Springs, CO, March 2007.
  • Keynote address, Harvard Medical School, 9th Annual Postgraduate Nutrition Symposium: Obesity and Inflammation, Boston, MA, March 2007.
  • “When is Amyloid Functional and When is Amyloidogenesis Pathogical?” The Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, March 2007.
  • Invited Speaker, Washington University, St. Louis, MO, February 2007.
  • Harvard School of Public Health Leadership Council, Boston, MA, October 2006.
  • Invited speaker, American Diabetes Association 66th Annual Scientific Session, Washington, DC, June 2006.
  • Sandler Program for Asthma Research Annual Meeting, San Francisco, CA, May 2006.
  • American Heart Association/American Diabetes Association Symposium on Metabolic Syndrome/Metabolic Risks: Implications, San Francisco, CA, May 2006.
  • Lawson Wilkins Lecture, Pediatric Academic Societies Annual Meeting, San Francisco, CA, May 2006.
  • HealthCare Ventures’ Scientific Advisory Retreat, West Palm Beach, FL, March 2006.
  • 8th Annual Postgraduate Nutrition Symposium, “Metabolic Syndrome and Onset of Cancer”, Boston, MA, March 2006.
  • Invited speaker, NIH, NIDDK, Bethesda, MD, September 2005.
  • American Diabetes Association 65th Scientific Sessions, San Diego, CA, June 2005.
  • Cystic Fibrosis Foundation Williamsburg Meeting, Williamsburg, VA, June 2005.
  • Sandler Program for Asthma Research Annual Meeting, San Francisco, CA, May 2005.
  • 2005 Keystone Conference on Diabetes Mellitus:  Molecular Mechanisms, Genetics and New Therapies, Keystone, CO, February 2005.
  • Martek Biosciences Forum:  The Role of Inflammation in Chronic Disease, Boulder, CO, January 2005.
  • Living Well to 100 Seminar, Tufts University, Boston, MA, November 2004.
  • Second Annual Leadership Council Meeting, Harvard School of Public Health, Boston, MA, October 2004.
  • Columbia University’s Division of Endocrinology Friday Seminar Series, New York, NY, October 2004.
  • NIH National Institute on Aging Workshop “Inflammation, Inflammatory Cytokines, and Aging”, Bethesda, MD, September 2004.
  • Sandler Program for Asthma Research Annual Meeting, May 2004, San Francisco, CA.
  • The Center for Bits and Atoms Colloquium, MIT, Cambridge, MA, April 2004.
  • Univ. of Pennsylvania’s Distinguished Lecture Series, Philadelphia, PA, January 2004.
  • NIH Adipose Tissue Secretory Function Symposium, Washington, DC, December 2003.
  • Harvard School of Public Health, Inaugural Leadership Council Meeting, Boston, MA, October 2003
  • Distinguished Lecture Series of Eli Lilly and Company, Indianapolis, IN, June 2003.
  • Molecular Endocrinology-Metabolic Disorders-Diabetes Series of Merck & Co., Rahway, NJ, April 2003.
  • NIH National Institute on Aging Distinguished Lecture Series at the Gerontology Research Center, Baltimore, MD, April 2003.
  • Harvard Medical Center Symposium at the Medical Education Center, Boston, MA, March 2003.
  • Endocrinology Grand Rounds, Beth Israel Deaconess Hospital, Boston, MA, March 2003.
  • Children’s Hospital Endocrine Division Seminars, Boston, MA, December 2002.
  • Insulin Action, Insulin Resistance, Inflammation and Atherosclerosis Symposium, Niagara Falls, NY, September 2002.
  • AASLD Conference on Nonalcoholic Steatohepatitis, Atlanta, GA, September 2002.
  • Biochemistry Pharmacology Discussion Group at the New York Academy of Sciences: Modulating Obesity, Diabetes, and Cardiovascular diseases with PPAR Ligands, New York, NY, September 2002.
  • Bristol-Meyers Squibb Pharmaceutical Research Institute Seminar, Hopewell, NJ, September 2002.
  • Aspen Lipid Conference: Lipid Transport, Aspen, CO, August 2002.
  • The Critical Role of Overlapping Pathways in Adipocyte and Macrophages in Metabolic Syndrome, Abbott Global Pharmaceutical Research and Development, Chicago, IL, June 2002.
  • University of Florida, Seminar Series of the Interdisciplinary Program at the College of Medicine, Gainesville, FL, February 2002.
  • Keystone Symposia: Molecular Control of Adipogenesis and Obesity/Diabetes Mellitus. Molecular Mechanisms and Genetics, Keystone, CO, January 2002.
  • NHLBI-NIDDK Working Group: The Pathophysiology of Obesity-Associated Cardiovascular Disease; State of the Science and Research Needs, Washington, DC, May 2001.
  • Rockefeller University, Seminars in Clinical Research, New York, NY, May 2001.
  • University of Minnesota, College of Biological Sciences, Department of Biochemistry, St. Paul, MN, April, 2001.
  • Keystone Symposia on Molecular and Cellular Biology: PPARs: a Transcriptional Odyssey, Keystone, CO, February 2001.
  • Johns Hopkins University School of Medicine, Baltimore MD, February 2001.
  • The Scripps Research Institute, La Jolla, CA, January 2001.
  • NAASO, Obesity in the New Millennium, Long Beach, CA, October 2000.
  • Keystone Symposia on Molecular and Cellular Biology: Diabetes Mellitus and Molecular Control of Adipogenesis and Obesity, February 2000, Taos, NM.
  • Endocrine Grand Rounds, Vanderbilt University School of Medicine, Department of Medicine, Nashville, TN, May 1999.
  • Endocrine Grand Rounds, Harvard Medical School and Beth Israel Deaconess Hospital, Boston, MA, October 1998.
  • Columbia University, Naomi Berrie Diabetes Center, New York, NY, September 1998.
  • Endocrine Grand Rounds, Harvard Medical School and Massachusetts General Hospital, Boston, MA, December 1998.
  • 2nd International IBC Conference on Insulin Resistance, Philadelphia, PA, October 1997.
  • NIH: The Brain and the Adipocyte: Integrating Diverse Signaling Pathways, Bethesda, MD, September 1997.
  • Longwood Area Diabetes/Metabolism Research Seminar, Boston, MA, November, 1997.
  • Aspen Lipid Conference: Lipoproteins, Insulin Resistance and Obesity, Aspen, CO, August 1997.
  • Keystone Symposium on Molecular and Cellular Biology, Park City, UT, January 1997.
  • Wise and Helen Burroughs Lecture, Iowa State University, Ames, IA, September 1996.
  • MIT, Boston Obesity Nutrition Research Seminar Series, Boston, MA, October 1996.
  • A. Association for the Study of Obesity, Baton Rouge, LA, December 1995.
  • Endocrine Grand Rounds, Harvard Medical School and Beth Israel Deaconess Hospital, Boston, MA, December 1995.
  • Boston Area Insulin Action Symposium, Woods Hole, MA, November 1995.
  • Rockefeller University Hospital, Endocrinology/Metabolism Seminar, New York, NY, April 1994.
  • Keystone Symposia: The Adipose Cell, Salt Lake City, UT, January 1994.
  • North American Association for the Study of Obesity, Milwaukee, WI, October 1993.
  • American Diabetes Association Annual Meetings, 1994, 1995, 1996, 1997, 1999, 2000, 2002, 2004, 2007, 2010, 2013.
  • Noble Lecture Series Speaker, Karolinska Institute, Stockholm, Sweden, June 2016.
  • Noble Lecture Series Speaker, Hamburg University Medical Center, Hamburg, Germany, June 2016.
  • Host and Keynote Speaker, Sabri Ülker Symposium, Sabri Ülker Foundation for Nutrition Research, Istanbul, Turkey, May 2016.
  • Guest Speaker, UCB Pharmaceuticals Supernetwork Conference, Reading, United Kingdom, April 2016.
  • Guest Speaker, Distinguished Lecture Series at the Lady Davis Research Institute for Medical Research at McGill, Montreal, Quebec, October 2015.
  • Academic Year Opening Lecture, Kadir Has University, Istanbul, Turkey, September 2015.
  • Inauguration Guest Speaker, iBG-Izmir Inauguration Innovating for Life Forum, Izmir, Turkey, September 2015.
  • Guest Speaker, 3rd International ImmunoMetabolism Conference, Chania, Crete, September 2015.
  • Invited Speaker, UCB Pharmaceuticals Science Congress, Brussels, Belgium, July 2015.
  • Commencement Keynote Speaker, Sabanci University, Istanbul, Turkey, June 2015.
  • Invited Speaker, IRCM Scientific Life Committee Meeting, Montreal, Quebec, May 2015.
  • Invited Speaker, Sabri Ülker Foundation for Nutrition Research, Istanbul, Turkey, May 2015.
  • Award Recipient Guest Speaker, Danone Institute Quality in Nutrition Value in Health Program, Milan, Italy, October 2014.
  • Opening Keynote Lecturer, IFCC, Istanbul, Turkey, June 2014.
  • Keynote Lecturer, World Immune Congress, Davos, Switzerland, March 2014.
  • IMBA 10 Year Anniversary Symposium, Vienna, Austria, June, 2013.
  • Cell Symposia, Immune-metabolic Crosstalk in Health and Disease, Toronto, Canada, June 2013.
  • Jean-Pierre Benhamou State-of-the-Art Lecture EASL Conference, Amsterdam, The Netherlands, April 2013.
  • World Immune Regulation Meeting VII – Davos, Switzerland, March 2013.
  • IGIS Servier 14th Symposium, Nice, France, March 2013.
  • Keystone Symposium on Neuronal Control of Appetite, Metabolism and Weight. Fairmont Banff Springs in Banff, Alberta, Canada, March 2013.
  • Organizer and speaker, Keystone Symposium on Autophagy, Inflammation and Immunity, Montreal, Quebec, February 2013.
  • Doğramacı Memorial Lecture, Bilkent University, Ankara, Turkey, November 2012.
  • Nobel Symposium, Karolinska Institute, Stockholm, Sweden, November 2012.
  • EMBL Symposium Diabetes and Obesity, Heidelberg, Germany, September 2012.
  • TUBITAK Meeting, Istanbul, Turkey, July 2012.
  • Charles Hollenberg Memorial Lectureship, Banting & Best Diabetes Center’s 23rd Annual Scientific Day, University of Toronto, Canada, May 2012.
  • Plenary Lecture, 8th Nestle International Nutrition Symposium, Switzerland, October 2011.
  • Jose Laguna Medal and Lecture, IUBMB, Cell Signaling Networks Merida Conference, Mexico, October 2011.
  • Plenary Lecture, European Congress on Obesity Meeting, Istanbul, Turkey, June 2011.
  • Chair of the Conference, ECO 2011 Satellite Symposium, Istanbul, Turkey, June 2011.
  • Opening Keynote lecture, The International Congress on Bioinformatics and Biomics, Kuşadası, Turkey, May 2011.
  • Sevim Büyükdevrim Memorial Lecture, 47th Diabetes Meeting, Antalya, Turkey, May 2011.
  • 12th Servier-IGIS Symposium, Nice, France March 2011.
  • Baker IDI Heart and Diabetes Institute, Melbourne, Australia, March 2011.
  • Garvan Institute, Sydney, Australia, March 2011.
  • Wertheimer Award Lecture, 11th International Congress on Obesity, Stockholm, Sweden, July 2010.
  • Plenary Lecture, European Society for Pediatric Gastroenterology, Hepatology and Nutrition, Istanbul, Turkey, June 2010.
  • Diabetes Conference, Ankara, Turkey, May 2010.
  • Closing Plenary, 11th Servier-IGIS Symposium entitled” The Stressed Beta-Cell”, March 2010.
  • Keystone Symposia, , Banff, Canada, February 2010.
  • Opening Keynote Lecturer, Diabetes Conference, Ankara, Turkey, May 2009.
  • 8th Congress of European Federation of Internal Medicine, Istanbul, Turkey, May 2009.
  • Invited lecture, Servier Institute of Research, Paris, France, March 2009.
  • Invited lecture, GlaxoKlineSmith Laboratory, Paris, France, April 2009.
  • Plenary Speaker, International Congress on Prediabetes and Metabolic Syndrome, Nice, France, April 2009.
  • Chair, 10th Anniversary Servier-IGIS Symposium: “A Decade of Islet Research: Implications for Understanding and Treating Type 2 Diabetes”, St. Jean-Cap-Ferrat, France, March 2009.
  • Plenary Speaker, Diabetes Dialogue Conference, Istanbul, Turkey, March 2009.
  • Keystone Symposia, Banff, Canada, January 2009.
  • Keynote Lecturer, 25th International Gastroenterology Symposium, Istanbul, Turkey, November 2008.
  • Plenary Lecturer, 2nd Advances in Diabetes Symposium, Barcelona, Spain, October 2008.
  • Plenary Lecturer, ESPE, Istanbul, Turkey, September 2008.
  • John Denis McGarry Lecture, Montreal Diabetes Research Center, Montreal, Canada, 2008.
  • Co-chair, 13th EASD/JDRF Oxford Workshop “Inflammation, Islets and Immunity, Oxford, England, August 2008.
  • European Research Council Meetings, Brussels, Belgium, June 2008.
  • Annual meeting of the Turkish Academy of Sciences, Istanbul, Turkey, June 2008.
  • Visiting scientist, Merck Frosst, Montreal Canada, January 2008.
  • Keynote Lecturer, GlaxoKlineSmith Symposium, January 2008, Montreal, Canada.
  • Keystone Symposia, Alberta, Canada, February 2008.
  • Keynote lecturer, Van d’Hebron Conference, Barcelona, Spain, December 2007.
  • Expo 2015 Planning Committee and Presentation, Paris, France, November 2007.
  • Keynote lecturer, 21st National Physical Medicine and Rehab Congress, Antalya, Turkey, October 2007.
  • Keynote lecturer, 2nd International Congress on Food and Nutrition, Istanbul, Turkey, October 2007.
  • Plenary lecturer, Nature/Merck Symposia on Inflammation, Rome, Italy, October 2007.
  • Keynote lecturer, 2nd International Congress on Prediabetes, Barcelona, Spain, April 2007.
  • Keynote speaker at ISH 2006 Sapporo Satellite Symposium on “Metabolic Syndrome, Adipocytokine, and Hypertension”, Sapporo, Japan, October 2006.
  • Novartis Foundation, “Fatty Acid & Lipotoxicity in Obesity and Diabetes”, Beijing, China, October 2006.
  • 134th Alfred Nobel Symposium, “The Adipocyte: a Multifunctional Cell”, Gotenburg, Sweden, August 2006.
  • Keynote speaker at the 4th Scientific Meeting of Adipocytokine Research, Tokyo, Japan, July 2006.
  • Keynote speaker at the 3rd Annual Scientific Meeting of the Insulin Resistance and Metabolic Syndrome, Tokyo, Japan, July 2006.
  • 31st FEBS Congress: Molecules in Health & Disease, June 2006, Istanbul, Turkey.
  • 42nd National Diabetes Congress, Istanbul, Turkey, May 2006.
  • Principal Speaker, Korean Society for the Study of Obesity, Asian Metabolic Syndrome Consensus Meeting, Seoul, Korea, April 2006.
  • Plenary Lecture, Asian Pacific Society of Atherosclerosis and Vascular Diseases 5th Annual Meeting, Jeju, Korea, April 2006.
  • Keystone Symposium on Adipogenesis, Obesity, and Inflammation, Vancouver, Canada, January 2006.
  • Annual meeting of the Turkish Academy of Sciences, Ankara, Turkey, December 2005.
  • Keynote Lecturer, NAASO Annual Scientific Meeting, Vancouver, Canada, October 2005.
  • “Obesity, Metabolism, and Cancer”, Ermatigen, Switzerland, October 2005.
  • Keynote Lecturer, 10th Adiposcience Symposium, Osaka, Japan, August 2005.
  • Chair, 4th International Stock Symposium: “Obesity and Inflammation”, Istanbul, Turkey, March 2005.
  • 6th Servier-IGIS Symposium: “Type 1 and Type 2 Diabetes: Less Apart than Apparent?”, St. Jean-Cap-Ferrat, France March 2005.
  • Altana Research Conference, Lake Constance, Germany, July 2005.
  • 3rd International Congress of Obesity, Antalya, Turkey, May 2004.
  • 2004 Keystone Symposium on Diabetes Mellitus: Molecular Signaling, Genes and Therapeutics, Banff, Canada, March 2004.
  • “Searching for Tomorrow-Yarini Arayis” High-Level Strategy/Brainstorming Meeting, Antalya, Turkey, February 2004.
  • 7th Scientific Session of the Japanese Society of Cardiovascular Endocrinology and Metabolism, Sapporo-city, Japan, November 2003.
  • Between Obesity and Diabetes Symposium, Barcelona, Spain, October 2003.
  • Invited lecture at Seoul National University, Seoul, Korea, October 2003.
  • Symposium Lecturer, Korean Society for Molecular Cell Biology, Seoul, Korea, October 2003.
  • 39th National Diabetes Congress, Istanbul, Turkey, May 2003.
  • Keynote Lecturer Japanese Circulation Society Meeting, Fukuoka, Japan, March 2003.
  • Sapporo Medical University, Internal Medicine, Sapporo, Japan, March 2003.
  • D.B. Brown Research Chair on Obesity, Quebec, Canada, November 2002.
  • Satellite Symposium on Obesity, Rio de Janeiro, Brazil, August 2002.
  • 9th International Congress on Obesity, Sao Paulo, Brazil, August 2002.
  • 38th National Diabetes Congress, Antalya, Turkey, May 2002.
  • 18th Ernst Klenk Conference, Cologne, Germany, February 2002.
  • International Focus on Diabetes Conference, Sicily, Italy, December 2001.
  • Invited lecturer at Bilkent University, Ankara, Turkey, June 2001.
  • Astra-Zeneca International Workshop on Obesity, Nice France, February 2001.
  • Japanese Diabetes Society Millennium Meeting, Nagoya, Japan, May 2000.
  • International Symposium on Nutrition and Dietetics, Ankara, Turkey, April 2000.
  • Recent Advances in Adipocyte Biology, Quebec City, Canada, November 1999.
  • Distinguished Lecturer, Oslo University’s Biotechnology Center, Oslo, Norway, October 1999.
  • 22nd Congress of Endocrine Society, Antalya, Turkey, October 1999.
  • European Congress of Pharmacology, Budapest, Hungary, July 1999.
  • IFCC Congress of Clinical and Molecular Biology, Florence, Italy, June 1999.
  • International Symposium on Lipoprotein Metabolism, Kyoto, Japan, December 1998.
  • 5th IUBMB: Biochemistry of Health and Disease, Jerusalem, Israel, October 1998.
  • 8th International Congress on Obesity, Paris, France, August 1998.
  • Pew Scholars Program in the Biomedical Sciences, March 1998, 1999, 2000, and 2001, in Puerto Vallarta, Mexico; Curaçao, Netherlands Antilles; Cozumel, Mexico; and Costa Rica, South America, respectively.
  • Japanese Diabetes Society, Molecular Diabetology, Nagoya, Japan, December 1997.
  • Annual Meeting of Adipo-Science, Osaka, Japan, August 1997.
  • Karolinska Symposium on Genes and Obesity, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden, August 1997.
  • 16th International Diabetes Federation Congress, Helsinki, Finland, July 1997.
  • Human Genome Project: Perspectives in Molecular Medicine, Ankara, Turkey, July 1997.
  • 22nd International Symposium on Growth Factors in Endocrinology and Metabolism, Vienna, Austria, October 1996.
  • 4th International Non-Insulin dependent Diabetes, Amsterdam, Netherlands, December 1996.
  • Centre National de la Recherce Scientifique, Biochemistry Seminar at University of Nice-Sophia Antipolis, Nice, France, November 1995.
  • Obesity: Recent Advances and Prospects for Therapy, London, UK, December 1995.
  • Cellular and Molecular Biology of Adipocyte Development and Growth, Ottawa, Canada, August 1994.
  • 7th International Congress on Obesity, Toronto, Canada, August 1994.

Research Support:

Completed Grants:

1996-1998 Joslin Diabetes Center DERC, P&F Grant PI Role of TNF receptors in insulin resistance
1996-1998 Harvard Clinical Nutrition Research Center, P&F Grant PI Leptin signaling and insulin sensitivity
1996-2003 Bristol-Myers Squibb Pharmaceutical Research. Inst. PI Metabolic role of adipocyte fatty acid- binding protein
1997-2000 American Diabetes Association Career Development Award PI Biological role of membrane-bound TNFa
1997-2002 Pew Scholar in Biomedical Sciences Award PI Fatty acid trafficking and metabolic control: the biology of FABPs
1998-2002 National Institute of Health (RO1) PI Leptin, cytokines and insulin resistance
2001-2002 Bristol-Myers Squibb Pharmaceutical Research Inst. PI Molecular basis of altered adipocyte biology in HIV-related lipodystrophy.
2003-2003 Biovitrum Pharmaceutical Corp. Research Institute PI FABP inhibitors in diabetes
2003-2005 American Diabetes Association PI Role of fatty acid-binding proteins in type 2 diabetes
2003-2006 Sandler Program for Asthma Research PI Novel pathways controlling inflammatory responses in asthma
2000-2004 NIH/NIDDK PI Molecular basis of adipogenesis
2005-2009 National Institute of Health (RO1) Co-PI The role of fatty acid-binding proteins in atherosclerosis
2008-2012 American Diabetes Association Post-doctoral Mentored Fellows PI Inflammatory mechanisms underlying insulin resistance and associated pathologies.
2009-2012 Syndexa Pharmaceuticals PI Targeting cellular stress pathways for the treatment of metabolic syndrome
2009-2011 Technology Development Accelerator, Harvard University PI Development of therapeutic antibody against diabetes and related metabolic diseases.
2011-2012 Technology Development Accelerator, Harvard University PI Investigating the therapeutic potential of cis and trans palmitoleate in metabolic disorders.
2011-2012 Broad Institute PI Nutrients engaging immune response
2010-2013 National Institute of Health) PI Deconvolution of adaptive metabolic responses of the endoplasmic reticulum
1997-2016 National Institute of Health (RO1) DK PI Lipids, inflammation, and insulin action
2008-2018 Juvenile Diabetes Research Foundation PI Endoplasmic reticulum stress, inflammation and type 1 diabetes 

Current Grants:

1996-2018 National Institute of Health (RO1) DK PI Inflammatory and stress signaling networks in metabolic disease
2014-2019 National Institute of Health (RO1) HL PI The role of immunometabolic pathways in atherosclerosis
2011-2017 UCB Pharmaceuticals PI Development of therapeutic antibody against diabetes and related metabolic diseases.
2012-2017 Servier Research Foundation PI Metabolic role of NRF in obesity and diabetes
2015-2019 National Institute of Health (RO1) NIAID PI The role of fatty acid binding protein aP2 in the pathogenesis and treatment of asthma
2016-2018 Juvenile Diabetes Research Foundation PI The role of lipid chaperone adipocyte protein 2 (aP2) in β-cell function, survival, and type 1 diabetes
2003- James Stevens Simmons Endowment PI Research and teaching funds

Active Fellowships:

Graduate Prize Fellowship                                                                  Khanichi Charles

Harvard University Merit Scholarship                                                Meric Erikci Ertunc, PhD

PEW Scholarship                                                                                Ana Paula Arruda, PhD

Naomi Berrie Award, Columbia University                                        Suneng Fu, PhD

Alfred Benzon Research Scholarship                                                  A. Benedicte Mengel, PhD

Human Frontiers Postdoctoral Fellow, AHA Career                          Takahisa Nakamura, PhD

Japanese Science Foundation Fellow                                                  Motohiro Sekiya, MD, PhD

Endocrine Fellowship, K08                                                                Amir Tirosh, PhD

Canadian Institutes of Health Research Fellowship                            Scott Widenmaier, PhD

AHA Postdoctoral Fellowship                                                            Ling Yang, PhD

Manpei Suzuki Diabetes Foundation Fellowship                                Kosei Eguchi, MD, PhD

Human Frontiers Postdoctoral Fellowship                                          Alex Barteldt, PhD

PEW Scholarship                                                                                Andrea Caricilli, PhD

T32 Awards: Ruth L. Kirschstein National Research Service           Lauren Robertson &

Award Short-Term Institutional Research Training Grants                 Vanessa Byles

Barth Syndrome Foundation                                                               Renata Goncalves, PhD



  • Co-Principal Investigator:

NIH/NIEHS- T32 ES016645 Interdisciplinary Training in Genes and the Environment

The two interrelated goals of our proposed training program are 1) To train true collaborative partners able to pursue methodological research that is motivated by, and helps to solve, difficult analytic issues that arise in studies of human environmental exposures and genetic susceptibility to complex diseases; and 2) To encourage interdisciplinary research, especially in genetics and the various “omics” arising from new methodologies for characterizing biological activity associated with environmental exposures in laboratory and population sciences.


  • Co-Principal Investigator:

NIH/NCI- T32 CA009078 Radiation Biology Training Program

The overall goal of this program is to train predoctoral and postdoctoral researchers to engage in and address the problem of understanding the effects of radiation and related agents at the cellular and molecular level.

  • Co-Principal Investigator:

NIH-T90DK070078 R90DK071507 Roadmap Training Grant in Genetics and

Complex Diseases

The goal of this program is to support graduate and postgraduate educational opportunities and training in an interdisciplinary context within the department of Genetics and Complex Diseases at Harvard School of Public Health.

  • Principal Investigator:

NIH-T32 ES007155 Training Program in Environmental Health

The overall goal of this program is to train environmental health scientists with an emphasis on excellence in the application of molecular and cellular tools to environmental problems. This program continues to recruit and maintain an outstanding group of graduate students and postdoctoral trainees. At the current time, we support 12 graduate students in four departments within the biological sciences at Harvard School of Public Health.

  • Principal Investigator:

NIH-T35ES007300 Undergraduate Minority Summer Internship Program

The goals of this summer program are to support research training in a number of diverse health-related areas for undergraduate minority students and prepare and promote the careers of undergraduate minority scientists.



U.S. Inhibition of Jun Kinase Issued
Australia Reducing ER Stress in the Treatment of Obesity and Diabetes Issued
U.S. Fatty Acid C16:1n7-Palmitoleate: A lipokine and biomarker for metabolic status Issued
EPO1, India, U.S. Reducing ER Stress in the Treatment of Obesity and Diabetes Pending
Australia, EPO1, Japan, U.S. Methods and Compositions for Treating  Hypercholesterolemia and Atherosclerosis Pending
U.S. Modulating Endoplasmic Reticulum Street in the Treatment of Tuberous Sclerosis Pending
Australia, Brazil, Canada, China, EPO1, India, Japan, PCT2, U.S. Antibody-based treatment against diabetes and metabolic disease Pending
PCT2 Use of trans-palmitoleate in identifying and treating metabolic disease Pending
PCT2 New targets for treatment of ER stress Pending

1 European Patent Office

2 Patent Cooperation Treaty

Past and Present Fellows:

Past Trainees:

Trainee Name Training Period Institution, Degree Title of Research Project Current Position
Atsumi, G 2001-2002 U. of Tokyo, 1998, PhD Role of lipid chaperons stress and adipocyte function

Associate Professor Teikyo U. Pharm.Dep.
Cao, H 2003- U. of Nevada, 2003, PhD Lipid chaperones and lipokines Earl Stedman Investigator, NIH, MD
Cao, Q 2002-2006 NYU Med. Sch., 2002, PhD ER stress in obesity and insulin action

Group Leader


Charles, K 2007-2014 Harvard School of Public Health, 2014, PhD Investigating the role of lipids in aging

Science Instructor

Marlborough School

Engin, F 2008-2014 Baylor College of Med., 2007, PhD Role of ER stress and inflammatory pathways

Assistant Professor

U. of Wisconsin

Erbay, E 2004- Ankara U. Sch. of Med., 1998 MD; U. of Illinois, 2004, PhD Macrophage stress responses and survival Assistant Professor

Bilkent U.

Dep. of MBG

Erikci, M 2008-2015 Harvard School of Public Health, 2014, PhD aP2 secretion from adipocytes Research Associate

Salk Institute

Fu, S 2004-2013 U. of Georgia, 2004, PhD Translational regulation of metabolism

Assistant Professor

Tsinghua U.

Furuhashi, M

2004-2009 Sapporo Med. Sch. 2002, MD, PhD Chaperons and metabolism Assistant Professor Sapporo Med. U.
Gorgun, C 1999-2009 Gazi Med. Sch., 1993, MD Mouse genetics and physiological studies

Research Liaison


Gregor, M 2005-2011 Harvard U., 2010, PhD ER stress in adipocyte biology Research Scientist
Hirosumi, J 2000-2001 U. of Tokyo, 1993, PhD Inflammation, JNK and insulin action Scientific Director

Fujisawa Pharm.

Hom, X

1999-2002 New York U., 1993. MD Inflammation in liver pathology Assistant Professor

UC San Diego

Hummasti, S 2008-2012 UCLA, 2006, PhD Regulation of ER stress by ATF6a Medical writer

Los Angeles, CA

Kono, K 2004-2006 Kyoto U., 2002, PhD Functions of lipid binding proteins Senior Scientist

Sankyo Co., Inc,

Li, P 2007- Peking U., 2003, PhD Chemical biological approaches

Senior Scientist, NIH, Bethesda, MD

Maeda, K



Osaka U., 1997, PhD Mechanisms of FABP function Associate Professor

Osaka U.

Maherali, N 2010-2012 U. of Calgary, 2004, BSc, Harvard U, 2010 PhD. Role of lipids in metabolism and inflammation

Research Scientist

Makowski, L 1998-2004 Harvard U., School of Public Health, 2003, PhD Mechanisms of inflammation

Assistant Professor

UNC Chapel Hill

Morgan, C 2005-2007 Pontifical Catholic U., 2002, PhD Inflammation in the adipose tissue

Assistant Professor

U. of Chile

Nakamura, T

2006-2012 Tokyo U., 2003, PhD Nutrient sensing and inflammatory responses Assistant Professor

Cincinnati Children’s Hospital

Otoo, N 2002-2003 U. of Ghana, 2000, BS JNK and insulin action in vitro

Postdoctoral Fellow
Ozcan, L 2004-2007 U. of Istanbul, 2004, MD ER stress in obesity and insulin action


Columbia U.

Ozcan, U 2002-2006 U. of Istanbul 2005, MD ER Stress in obesity and insulin action

Assistant Professor

Children’s Hospital

Pers, B 2011-2015 U. Copenhagen, 2011, PhD Mathematical modeling of complex networks  



Scheja, L 1996-2001 Tubingen U., 1996, PhD Cellular responses to lipid signals Assistant Professor

Un Tubingen


Sekiya, M




U. of Tokyo, 2005, MD, PhD


Lipid chaperones and metabolism


Assistant Professor,

Tokyo University

Sethi, J 1996-2000 Oxford U., 1997, PhD TNF and Insulin Action Lecturer

Cambridge U.

Tan, G 2000-2002 Auburn U., 1999, MS Mechanisms of adipocyte differentiation

Research Scientist

Millennium Pharm.

ten Freyhaus, H 2008-2010 U. of Cologne, 2004, MD STAMP2 and macrophage function

Attending Physician

U. of Cologne

Tirosh, A 2010-2014 Ben-Gurion U., 1999, MD; Ben-Gurion U., 2001, PhD Adaptive response network of the ER Assistant Professor

Harvard Med. School

Center Director

Sheba Medical Center

Tong, Q 1997-2002 Ohio State U., 1997, PhD Adipocyte differentiation Associate Professor

Baylor College

Tsai, J 1999-2004 Harvard U. School of Public Health, 2004, PhD Role of GATA factors in brown adipogenesis

Research Scientist
Uysal, T 1995-2001 Carnegie Mellon, 2003, MBA TNF-a, inflammation and insulin action CEO and President

Syndexa Pharm.

Vallerie, S 2003-2010 Emory U., 2000, BS Macrophage JNK and insulin action Postdoctoral Fellow

U. of Wash., Seattle

Wellen, K 2000-2006 Harvard U. School of Public Health, 2006, PhD Inflammatory and metabolic responses

Assoc. Professor

U. Penn.

Xu, H 1996-2000 Harvard U. School of Public Health, 1996, PhD Inflammation, TNF and adipose tissue Assoc. Professor

Brown U. Med. Sch.

Yalcin, A 2008-2014 Georg August U, 2006, PhD Functional of miRNAs

Assistant Professor

Adnan Menderes U.

Yang, L

2007-2014 Kent State U., 2007, PhD

ER stress in osteoarthritis Assistant Professor

U. of Iowa

Yilmaz, E 2002-2005 Ankara U. Med. Sch., 1999, MS Stress pathways, Jnk and insulin action Associate Professor

Ankara U.

Current trainees:  
Trainee Name Training Period Institution, Degree Title of

Research Project

Current Source of Support
Arduini, A 2011- U. Valencia, School of Medicine, PhD Protein folding and inflammation Hotamisligil Research Funds
Arruda, AP 2009- Federal U. of Rio de Janeiro, 2008, PhD Mitochondrial function Pew Scholarship
Bartelt, A 2013- U. Med. Center Hamburg-Eppendorf, 2012, PhD Molecular adaptations of adipose tissue to cold and obesity Deutsche Forschungsgemeinschaft (DFG, German Research Council)
Calay, E 2008- Harvard School of Public Health, 2014, PhD Metabolic-immune response to nutrients NIH-T32- Cancer Training grant
Caricilli, A 2014- State U. of Campinas, 2011, PhD Modulation of PKR by gut-derived molecules Pew Scholarship
Eguchi, K 2013- U. of Tokyo, 2000, MD, U. of Tokyo, 2008, PhD aP2 on macrophage inflammatory responses Japanese Science Foundation Fellow
Garfinkel, B 2016- The Hebrew U. of Jerusalem, 2015, PhD Transcriptional regulation of metabolism Hotamisligil Research Funds
Goncalves, R 2015- Medical Biochemistry Institute, Federal U. of Rio de Janeiro, 2010, PhD Mitochondrial stress response during meta-inflammation Barth Syndrome Foundation
Guney, E 2015- Istanbul U., 2014, MD Brown adipocyte physiology in response to acute and long term activation Sabri Ülker Fellowship
Li, M-D 2016- Yale U., 2015, PhD Intracellular signaling pathway of adipose tissue-secreted hormone FABP4 Hotamisligil Research Funds
Parlakgul, G 2015- Istanbul U, 2014, MD Role of ER structure and dynamics in metabolism and disease Sabri Ülker Fellowship Funds
Prentice, K 2015- U. of Toronto, 2015, PhD Secreted aP2 in pancreatic islet cell function Canadian Institute of Health Fellowship
Robertson, L 2013- Smith College, 2009, BS Autophagy and metabolism Joslin NIH-T32
Smith, B 2015- U. of Illinois, 2014, PhD Next-generation nutritional screening Hotamisligil Research Funds
Tuncman, G 2000- Ankara U. Sch. of Med., 1999, PhD Role of inflammatory stress pathways and lipid chaperons

Juvenile Diabetes Research Foundation
Widenmaier, S 2010- U. of Regina, 2005, BSc, U. of British Columbia, 2010 Compensatory mechanism in obesity and metabolic stress

Canadian Institute of Health Fellowship
Yilmaz, M 2012- Bilkent U., 2011, BS Lipid chaperones and ER proliferation DBS fellowship