Dr. Dennis Liotta

Dennis Liottahttps://scholarblogs.emory.edu/liotta/ 

Born: January 31, 1949

Brooklyn, N.Y.

Married, two sons


Queens College of CUNY, B.A., 1970

The City University of New York: Ph.D., with R. Engel, 1974

The Ohio State University: Postdoctoral, with L. Paquette, 1974-1976


Assistant Professor of Chemistry, Emory University, Atlanta, Ga., 1976-1982; Associate Professor, 1982-1988; Professor, 1988-present; Samuel Candler Dobbs Professor of Chemistry, 2000-present; Department Chairman, 1993-1996

Fellow of the Alfred P. Sloan Foundation, 1980-1984

Recipient of a Camille and Henry Dreyfus Teacher Scholar Fellowship, 1981-1986

Alexander von Humboldt Senior Scientist Fellow, 1994-1996

Emory Williams Distinguished Teaching Award for the Natural Sciences, Emory University; 1987

Co-Chair, National Science Foundation Workshop on Reactive Intermediates, 1980-1983

Co-Chair, Gulf Coast Chemistry Conference, 1981-2007

Co-Chair, The Latest Trends in Organic Synthesis Symposia19862000

Chair, Symposium on Molecular Modeling, SERMACS 88, Atlanta, GA, 1988

Chair, Symposium on Molecular Modeling, Molecular Design, Ltd., Murray Hill, NJ, 1989

Chair, Gordon Conference on Heterocyclic Chemistry, 1989

Editor, “Organoselenium Chemistry,” Wiley- Interscience, 1987

Editor, Tetrahedron  “Symposium in Print” -“Recent Aspects of Organoselenium Chemistry”

Editor, Advances in Molecular Modeling, Vol. 1, 2 and 3, JAI Press, 1988, 1990, 1995

Editor (with M. Volmer), Organic Syntheses Reaction Guide, Wiley- Interscience, 1991

Editor (with V. Cornel), Recent Reviews, The Journal of Organic Chemistry, 19951999

Member of the Board of Editors, Encyclopedia of Reagents for Organic Synthesis, Wiley- Interscience, 19921997

Consultant, R. W. Johnson Pharmaceutical Research Institute 19852000

Consultant, Glaxo Group Ltd. (United Kingdom), 1991-1993

 Consultant, Burroughs Wellcome (Glaxo Wellcome), 1992-1996

Consultant, The Wellcome Research Foundation Ltd. (United Kingdom), 1992-1995

Consultant, Boehringer Ingelheim, 19942000

Consultant, BioMega (Montreal), 1993-1997

Member, Scientific Advisory Board, AtheroGenics, 19952007

Member, Scientific Advisory Board, Triangle Pharmaceuticals, 19951998

Chair, Scientific Advisory Board, Triangle Pharmaceuticals, 19982003

Instructor, American Chemical Society Short Course on Molecular Modeling, Athens, GA, 19882000

Chairman, Georgia Section, American Chemical Society, 1988

Vice President for Research, Emory University, Atlanta, GA, 1996-2000

Member, Executive Committee, Division of Organic Chemistry, American Chemical Society, 1990-1992; Secretary-Treasurer, 1994-1997

Ad Hoc Member, Medicinal Chemistry Study Section, The National Institutes of Health, 1988, 1994

Ad Hoc Member, Bioorganic and Natural Products Study Section, The National Institutes of Health, 1992

Ad Hoc Member, Personnel C Advisory Panel, The American Cancer Society, 1993-1994

Member, Drug Discovery Study Section, The American Cancer Society, 1995-2006

Member, AIDS and Related Research Study Section, National Institutes of Health, 1995-1997; Chair, 1997-1998

Director, Molecular Therapeutics Program, Winship Cancer Center, 19942000

Member, External Advisory Committee, University of Alabama, Birmingham, Center for AIDS Research, 1996-2001

Member, Executive Committee, MSP, DGBBS, 2001-2007

Co-Director, Knowledge Transfer, Center for Behavioral Neuroscience, 1999-2001

Member, Board of Directors, F.O.B. Synthesis, Inc., 2001-present

Biomedical Industry Growth Award recipient, Georgia Biomedical Partnership, 2003

Member, Scientific Advisory Board, Chimerix, Inc., 2003-present

Member, Scientific Advisory Board, Slainte Bioceuticals, Inc. , 2003-2007

Fellow, American Association for the Advancement of Science, 2003-present

Chair, Scientific Advisory Board, iThemba Pharmaceuticals, 2001-present

Member, Scientific Advisory Board, MetaStatix, Inc., 2005-2008

Herty Award Recipient, Georgia Section of the ACS, 2005

Member, Scientific Advisory Board, University of Pittsburgh Center for Chemical Methodologies & Library Development, 2005-2013

Member, University of Georgia Center for Drug Discovery, 2005-present

Distinguished Faculty Lecturer, Emory University, 2006

Member, Board of Directors, Georgia Advanced Technology Ventures 2006-present

Director, RSA Drug Discovery Training Program, 2007-present

Member, Board of Directors, Achilion Pharmaceuticals, 2008-present

Member, Scientific Advisory Board, Altiris, 2008-present

Director, Emory Institute for Drug Development, 2009-present

Co-Director, Emory Chemical Biology Consortium (NCI), 2009-present

Consultant, Cardioxyl Pharmaceuticals, 2009-present

Editor-in-Chief, Medicinal Chemistry Letters, American Chemical Society, 2010-present

Member, Biological Chemistry and Macromolecular Biophysics (BCMB) Study Section, The National Institutes of Health, 2010

Gisvold Award, Department of Medicinal Chemistry, University of Minnesota, 2010

Fellow, American Chemical Society, 2010-present

ACS Medicinal Chemistry Hall of Fame, 2010

Thomas Jefferson Award for Teaching, Emory University, 2011

Member, Scientific Advisory Board, Cerecor Inc, 2011-present

IP Legend Award, Georgia State University College of Law and J. Mack Robinson College of Business, 2011

175 Emory Historymakers Medal, 2012

Uncommon Courage Award, Queens College, 2012

Honorary Doctorate, Queens College, 2012

Honorary Doctorate, University of Queensland, Queensland, Australia, 2012

Distinguished Alumni Award, The Ohio State University, 2013

Fellow, National Academy of Inventors, 2013

 Emory University Senate Lecture Series Panel, 2013

Licensing Deal of the Year, Emory Office of Tech Transfer, 2014

Fellow, Australian Academy of Technological Sciences and Engineering, 2014

Georgia Bio Shark Tank Winner, 2014

ACS-BMS Smissman Award, 2015

Antonín Holý Memorial Lecture Award, 20th International Conference on Antiviral Research/ISAR, 2015


American Chemical Society

American Association for the Advancement of Science

International Society for Antiviral Research



R01 A1028731-23 (Liotta Dennis)                              01/01/2013-12/31/2017        1.35 Academic

NIH/NIAID                                                                   $425,820.00                         0.45 summer

Non-Carbohydrate Approaches to Anti-AIDS Nucleosides

Design & synthesis of novel nucleoside analogs with improved resistance profile


P30 AI050409 (Curran James Walter)                       8/1/12012 – 07/31/2017      0.45 Academic

NIH/NIAD                                                                     $1,469,736.00                      0.15 summer

Emory Center for AIDS Research


R01AI071002-06A1 (Plemper Richard Karl)              07/01/2012-06/30/2017       0.30 Academic

NIH                                                                            $301,136.00                           0.10 summer

Developing Myxovirus Inhibitors with Expanded Pathogen Target Range

This project employs a structure-based drug design strategy to develop a novel class of MV fusion inhibitors to applicable antiviral drugs


29XS132 TO08 (Haian Fu)                                         06/24/2009-06/23/2014      .09 Academic

SAIC-FREDERICK                                                       $49,993.70                        .03 summer

Emory Chemical Biology Discovery Center in the NCI Chemical Biology Consortium

The major goals of this project is to discover and develop new and innovative, targeted cancer therapies.


000021215 (Liotta Dennis)                                         01/01/2012-10/31/2013   0.45 Academic

BIO Ventures for Global Health                                  $800,000.00                    0.15 summer

Role: Principal Investigator

Global Health Primer

Web- based database tool to track work done in R&D related to neglected tropical disease


R37 AI028431 (Liotta Dennis)            7/01/1989-4/30/2013              0.90 Academic

NIH/NIAID (Merit Award)                                            $1,469,736.00/ NCE

Non-Carbohydrate Approaches to Anti-AIDS Nucleosides

Design & synthesis of novel nucleoside analogs with improved resistance profiles


Chair, Graduate Recruitment Committee, 1977-1987

College Curriculum Committee, 1981-1984

3-2 Cooperative Engineering Program Committee, 1982-1983

Graduate Student Teaching Award Committee, 1982-1984

Winston Churchill Scholarship Committee, 1982-1983

Arts and Sciences Computer Advisory Committee, 1982-1986

Stipe Society Award Selection Committee, 1982-1984

College / Dental School Cooperative Committee, 1982-1984

Pre-Medical/Pre-Dental Advisory Committee, 1982-1986

Faculty Advisor to Undergraduates, 1977-present

Director of Graduate Studies, 1983-1987

Graduate Executive Committee, 1983-1987; 1990-1992

Grievance Subcommittee, Graduate Executive Committee, 1985-1986

Committee on Evaluation of Teaching, 1985-1986

Policy and Procedure Subcommittee, Graduate Executive Committee, 1986-1987

Emory Graduate Dean Search Committee, 1988-1989

University Patent and Copyright Committee, 1988-1990

College Enrollment Committee, 1989 -1990

Emory / Georgia Tech Joint Ph. D. Committee, 1990-1993

College Nominating Committee, 1990, 1992

Responsibility in Research Task Force, 1990-1992

Emory College Dean Search Committee, 1990-1991

Chair, Chemistry Department Faculty Search Committee, 1990-1991

Graduate Executive Committee, 1990-1992

Chair, Chemistry Department Computer Committee, 1990-1993

University Research Committee, 1990-1993

Academic Computing Advisory Committee, 1992-1996

Chair, Chemistry Department Computer Committee, 1990-1993

Chemistry Department Undergraduate Education Committee, 1990-1996

Chair, Chemistry Department, 1993-1996

Graduate Dean Search Committee, 1994-1995

Structural Biology Eminent Scholar Search Committee (Biochemistry Dept.), 1994-1997

Associate V. P. for Institutional Advancement Search Committee, 1995

Director, Molecular Therapeutics Program, Winship Cancer Center, 1994

Member, President’s Senior Staff, 1996-1998

Member, Administrative Council, 1998

Member, Provosts’ Staff, 1996

Member, Trustees Executive Committee, 1996

Member, Executive Vice President for Health Affairs Advisory Committee, 1996

Chair, GMHI-Emory West Executive Committee, 1998

Co-Director, Knowledge Transfer, Center for Behavioral Neuroscience, 1999-2001

Associate Director for Research Development, Emory Center for AIDS Research, 2005-present Director Developmental Core, Emory CFAR, 2001-2005

Executive Committee, MSP, DGBBS 2001-2004

Chair, Faculty Science Council, 2004-present

Member, College Governance Committee, 2004

Member, Development and University Relations Faculty Council, 2005

Member, Global Health Institute Internal Advisory Committee, 2006-present

Member, Emory College of Arts & Science Dean Search Committee, 2009-2010    

Member, Hightower Awards Committee, 2009

Member, Center for AIDS Research Program Council, 2010-present

Member, Chemistry Department Outreach Committee, 2012-present


Professor Dennis Liotta has helped to transform HIV/AIDS from a death sentence to a chronic infection in which patients are able to live active, near normal lives.  The Emory Office of Technology Transfer estimates that greater than ninety per cent of all of the HIV-infected persons in the United States take (or have taken) one of the drugs he invented.  In his current role as Executive Director of the Emory Institute for Drug Development, Dennis oversaw the discovery and development of another novel nucleoside analogue, EIDD-2023, as a potential treatment for single-stranded RNA viral infections.  His research group has also recently discovered the first potent, dual tropic (CCR5/CXCR4) HIV entry inhibitor.

Over the past two and a half decades Dr. Liotta’s research has focused on the discovery and development of novel antiviral, anticancer and anti-inflammatory therapeutic agents.  He is one of the leaders of the Emory team that discovered the antiviral drug, Emtriva (emtricitabine), which was approved for treating HIV in July 2003.  Emtriva is a component of the ground breaking, once a day, triple combination therapy, Atripla, which is now universally accepted as the drug combination of choice for treating HIV infected patients.  In addition, he is the inventor of record for several clinically important antivirals, including Epivir, Reverset, Racivir and Elvucitabine.  He is also the lead inventor of Q-122, a safe, orally available clinical agent for controlling hot flashes in post-menopausal women.

For a description of Dr. Liotta’s current research interests, see his website: https://scholarblogs.emory.edu/liotta/


3rd Gulf Coast Chemistry Conference, Gulf Shores, AL

1980 Gordon Conference on Organic Reactions and Processes

University of Central Florida, Orlando

Symposium on Organic Reactions, Southeast-Southwest Regional ACS Meeting, New Orleans  University of New Orleans, New Orleans, LA

Kennesaw College, Kennesaw, GA

NSF Workshop on Reactive Intermediates, Callaway Gardens, GA

Temple University, Philadelphia

University of Pennsylvania, Philadelphia

Clemson University, Clemson, SC

Symposium on Organoselenium Chemistry, 183rd National ACS Meeting, Las Vegas

Eastman Kodak Co., Kingsport, TN

Schering-Plough Corp., Bloomfield, NJ

Louisiana State University, Baton Rouge

Georgia State University, Atlanta

NSF Workshop on Synthesis and Natural Products Chemistry, Squam Lake, NH

NSF Workshop on Reactive Intermediates, Pingree Park, Colorado

Plenary Lecture, 4th International Conference on the Organic Chemistry of Selenium and Tellurium, Birmingham, England

NSF Workshop on Reactive Intermediates, Santa Catalina, CA

Brown University, Providence, RI

University of Virginia, Charlottesville

Florida State University, Tallahassee

Ohio State University, Columbus

Auburn University, Auburn, AL

Warner-Lambert/Parke-Davis, Ann Arbor, MI

ACS Creative Synthesis Symposium, St. Louis, MO

1st “Latest Trends in Organic Synthesis” Symposium, Virginia Polytechnic Institute, Blacksburg,

Monsanto Agricultural Products, St. Louis, Missouri.

University of South Florida, Tampa

Georgia Institute of Technology, Atlanta

College of Charleston, Charleston, SC

McNeil Pharmaceutical, Spring House, PA

University of Georgia, Athens

  1. I. Dupont, Wilmington, DE

1985 Gordon Conference on Heterocyclic Chemistry, New Hampton, NH

Burroughs Wellcome Corp., Research Triangle, NC

Eastman Kodak Co., Rochester, NY

University of Rochester, Rochester, NY

Schering-Plough Corp., Bloomfield, NJ

University of Maryland, College Park

Tulane University, New Orleans

Ortho Pharmaceutical, Raritan, NJ

The 2nd “Latest Trends in Organic Synthesis” Symposium, Virginia Polytechnic Institute, Blacksburg

McNeil Pharmaceutical, Spring House, PA

Florida State University, Tallahassee

Ortho Pharmaceutical, Raritan, NJ

Merck, Sharpe and Dohme, Rahway, NJ

Sandoz Research Institute, East Hanover, NJ

University of Michigan, Ann Arbor

American Association of Chemists, Atlanta

EXXON, Baton Rouge, LA

Burroughs Wellcome Corp., Research Triangle, NC

Philadelphia Organic Chemists Club (POCC), Philadelphia

University of Alabama, Tuscaloosa

BOC Group, Murray Hill, NJ

1989 Gordon Conference on Reactions and Processes, New Hampton, NH

The Squibb Medical Research Institute, Princeton, NJ

Molecular Design Ltd., Morristown, NJ

Hoffmann La Roche, Nutley, NJ

The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ

1989 Gordon Conference on Reactions and Processes, New Hampton, NH

University of Montreal, Montreal, Canada.

University of Waterloo, Waterloo, Canada.

BioMega, Inc., Montreal, Canada.

FMC Corporation, Princeton, NJ

State University of New York, Stony Brook, NY

SERMACS 89, Winston-Salem, NC

Glaxo Group Ltd., Greenford, England, UK.

Hoechst-Roussel Pharmaceutical, Somerset, NJ

Hunter College of CUNY, New York City

Lederle Laboratories, Pearl River, NY

University of Richmond, Richmond, Virginia

Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT

BioMega, Inc., Montreal, Canada

The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ

Burroughs Wellcome Corp., Research Triangle, NC

Merck, Sharpe and Dohme, Rahway, NJ

Eli Lilly and Co., Indianapolis

5th International Symposium on Antiviral Research, Vancouver, BC, Canada

Ernest Guenther Award Symposium, San Francisco

Abbott Research Laboratories, Chicago

Sigma Xi / Interscience Council, West Georgia College, Carrollton, GA

Nucleoside Nucleotide Round Table, Park City, UT

Bristol-Myers Squibb, Wallingford, CT

BioMega, Inc., Montreal, Canada

North Carolina State University, Raleigh,

Clemson University, Clemson, SC

Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT

Queens College of CUNY, Queens

North Jersey ACS Organic Topical Group, South Orange, NJ

New York Academy of Science, Chemical Sciences Section, New York City

New York University, New York City

Merck, Sharpe and Dohme, Rahway, NJ

6th International Society on Antiviral Research Conference, Venice, Italy

University of Ferrara, Ferrara, Italy

The Wellcome Research Foundation, Beckenham, UK

Glaxo Group, Ltd., Greenford, UK

1993 Nucleoside Roundtable, Park City, UT

Bioorganic Symposium, The Chemical Society, Loch Tay, Scotland

Marion Merrell Dow, Cincinnati, OH

Southeast Regional Meeting, American Chemical Society, Johnson City, TN

Fisons Pharmaceuticals, Rochester, NY

University of Rochester, Rochester, NY

BioMega, Inc., Montreal, Canada

Miles Pharmaceuticals, New Haven, CT

University of Central Florida, Orlando

University of Wisconsin, Milwaukee, WI

Georgia Institute of Technology, Atlanta

The Dupont-Merck Pharmaceutical Co., Wilmington, DE

Medicinal Chemistry Symposium, Buffalo, NY.

Georgia Biomedical Partnership Executive Forum, Atlanta

1994 Gordon Conference on Heterocyclic Compounds, New Hampton, NH

The Upjohn Co., Kalamazoo, MI

BioMega, Inc., Montreal, Canada

Colorado State University, Fort Collins, CO

The University of Alabama, Birmingham, AL

American Cyanamide, Princeton, NJ

Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT

Ciba-Geigy, Summit, NJ

Symposium on Drug Design and Synthesis, American Chemical Society Meeting, Chicago

University of Louisville, Louisville, KY

Merck Research Laboratories, West Point, PA

University of Chicago, Chicago

American Institute of Chemists, Symposium on Education, Charlotte, NC

1996 Gordon Conference on Heterocyclic Compounds, New Hampton, NH

Merck Research Laboratories, West Point, PA

Instituto Di Ricerche Di Biologia Molecolare, Rome, Italy

Eli Lilly and Company, Indianapolis

BioMega, Inc., Montreal, Canada

Latest Trends in Organic Chemistry, Gainesville, FL

University of Mississippi, University, MS

Johnson & Johnson Focused Giving Scientific Symposium, New Brunswick, NJ

Bristol Myer Squibb, New Brunswick, NJ

10th International Conference on Antiviral Research, Atlanta

New York University, New York City

Proctor and Gamble, Norwich, NY

16th Int. Congress of Heterocyclic Chemistry, Bozeman, MT

University of Tennessee, Knoxville

Second International Conference on Therapies for Viral Hepatitis, Kona, Big Island, HI

Brigham Young University, Provo, UT

9th Chemistry as a Life Science Symposium, Merck, Rahway, NJ

11th International Conference on Antiviral Research, San Diego, CA

Novum Lecture in Organic Chemistry, Institute of Biosciences at NOVUM, Stockholm, Sweden

Biotechnology Industry Organization ’98 International Meeting, New York, NY

216th National American Chemical Society Meeting, Boston

Eighth Symposium on the Latest Trends in Organic Synthesis, Gainesville, FL

1st International Conference on Discovery & Clinical Development of Antiretroviral Therapies, St. Thomas, West Indies

3rd International Conference on Therapies for Viral Hepatitis, Maui, HI

13th International Conference on Antiviral Research, Baltimore

DIA Workshop on Pharmaceutical Research in Academic Health Centers: New Paradigms, Philadelphia

Recent Advances in the Medicinal Chemistry of Anti-Infective Agents: New Targets and Opportunities, Cambridge, UK

15th Winter Fluorine Conference, St. Petersburg, FL

Washington State University, Pullman, WA

HEP DART Conference, Maui, HI

Merck, Rahway, NJ

AtheroGenics, Atlanta

Pharmasset, Atlanta

Zygogen, Atlanta

XII International HIV Drug Resistance Workshop, Cabo San Lucas, Mexico

McGill University, Montreal, Quebec, Canada

HIV DART, Naples, FL

University of Minnesota, Minneapolis

10th Symposium on Latest Trends in Organic Synthesis, Gainesville, FL

GA Tech, Atlanta

GA Life Sciences Summit Panel on International Partnerships, Atlanta

BIO 03 – iThemba Pharmaceuticals, Atlanta

Novel Anti-HIV / HBV Analogs, Gilead Sciences, Foster City, CA

University of Stellenbosch, Stellenbosch, South Africa

Scios, Inc., Fremont, CA

Global Access to HIV AIDS Treatment Panelist, Atlanta

Medical University of South Carolina, Charleston

University of Illinois, Chicago

Auburn University, Auburn, AL

Winship Cancer Institute Drug Development and Pharmacogenomics Academy, Emory University, Atlanta

Heterocyclic Compounds, Gordon Research Conference, Salve Regina University, Newport, RI

Organic Colloquium, Proctor & Gamble, Cincinnati

Amgen, Santa Barbara, CA

Davidson College, Davidson, NC

Scripps’ Distinguished Lecturer Series, La Jolla, CA

Winter Conference on Medicinal and Bioorganic Chemistry, Clearwater, FL

Merck, Rahway, NJ

University of Kansas, Lawrence, KS

Bio2Biz, Durban, South Africa

BioDesign 2006, Atlanta

Mid-Atlantic Bio, Washington DC

Imperial College, UK

UNC, Chapel Hill

ACS National Meeting, Chicago

Emerson Symposium, Emory

MD/PhD Student Visit Keynote Address, Emory

Career Development Symposium, Emory

University of Pittsburgh

Johnson & Johnson, La Jolla, CA

New Jersey ACS Symposium, Somerset

ACS Academia / Industry Forum, Kennesaw State

Queen’s College, NY

American Medical Writers Association Conference, Atlanta

Georgia Life Sciences Summit, Atlanta

CCNE Distinguished Lecture, Winship Cancer Institute, Emory University, Atlanta

Family Weekend Presentation, Emory University, Atlanta

EGAP Panel, Emory University Law School, Atlanta

CU Roche, Boulder

UNC, Greensboro

ACS National Meeting, Philadelphia

ACS National Meeting, Salt Lake City

Leo Paquette Legacy Symposium, Columbus, OH

AACR Frontiers in Cancer Prevention Research Conference, DC

Emory-GA Tech Frontiers of Cancer Nanotechnology, Atlanta

University of South Florida, Tampa

USF Moffitt Cancer Center, Tampa

AACR Prevention Conference, Atlanta

ACS Robins Symposium, Salt Lake City

2nd Annual UNCG Symposium in Medicinal Biochemistry, UNC, Greensboro

Bio2Biz, Keynote Address, Durban, South Africa

Princeton University

Therapeutic Applications of Computational Biology and Chemistry 2010, UK

University of Minnesota, Minneapolis

University of Buffalo, Foster Colloquium

Oxford College Commencement Address, Oxford, GA

Third European Workshop in Drug Synthesis, University of Siena, Italy

Clinton Health Initiative Conference, DC

McGill University, Montreal

Merck, Kenilworth, NJ

2010 Institute for Translational Medicine and Therapeutics International Symposium, U of Penn School of Medicine

Funding, Organizational & Scientific Challenges for Neglected Diseases, Boston

The Role of Innovation in Addressing Global Health, US Department of State Symposium, DC

Temple University, Philadelphia

Keystone Symposium, Snowbird, UT

MIKI (Universities of Minnesota, Iowa, Wisconsin and Illinois) Conference, Keynote Speaker, University of Kansas, Lawrence

Vanderbilt University, Nashville

Singapore Management University, IIE Distinguished Speaker, Singapore

Organic Chemistry: Perspectives on the 21st Century IV, Fiji

Alabama Drug Discovery Alliance Symposium, Keynote Speaker, University of Alabama, Birmingham

International HIV & Hepatitis Virus Drug Resistance Workshop, Cabo San Lucas, Mexico

Accelerating IP and Innovation in South Africa, Cape Town

Emory University Pathology Department Grand Rounds Speaker

Drug Discovery in Academia, Johns Hopkins

AIDS @ 30, Harvard University

University of Queensland, Australia

ACS Philadelphia, 2012, Entrepreneurship Workshop

World International Patent Organization Re:Search Annual Meeting, Opening Remarks

ACS National Meeting, Entrepreneurship: Drug Discovery Innovation at Start-Up, Small and Medium-Sized Biotechnology

UNISA, The In-House Management of Inventions and Patents, Pretoria, South Africa

Grand Rounds, Emory School of Medicine

Creating and Leveraging IP in Developing Countries: A Power Tool for Economic and Social Growth, Durban, South Africa

SERMACS, Plenary Lecture and Undergraduate Keynote, Atlanta

ACS, Presidential Symposium on Entrepreneurship, National Meeting, Indianapolis

ACS, Entrepreneurial Skills Interactive Symposium/Workshop, National Meeting, Indianapolis

Department of Medicine Leadership Retreat, Emory University

R.R. Baker Lecture, UC, Santa Barbara

David Chu Lecture, UGA

University of Michigan, Medicinal Chemistry Department

University of Michigan, Center for the Discovery of New Medicines

National Medicinal Chemistry Symposium, Charleston

Latest Trends in Organic Synthesis, Brock University, Ontario

21st International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Poland

Southeastern Medical Scientist Symposium, Keynote Speaker, Emory

Africa: The Next Biotech Frontier, BIO International Convention, San Diego

Health Connect South, Atlanta

Ausbiotech 2014, National Conference

The Scripps Research Institute, La Jolla

Winters Lecture, Virginia Commonwealth University

The Charles Liotta Symposium; GA Tech

Nanjing University, Nanjing PRC

Fudan University Hospital, PRC

Georgia State University, Atlanta

University of Queensland, Australia

ITMAT Symposium, University of Pennsylvania

Frontiers in Medicinal Chemistry, Antwerp

University of North Carolina, Asheville

Preparing Future Innovators, Emory University

BIO, Philadelphia

Swedish Chemical Society Trends in Organic Chemistry; Stockholm

Innovation in Drug Discovery, NJACS; Somerset, NJ

Pacifichem 2015; Honolulu


Introductory Organic Chemistry                                                       Chem. 121, 122, 221, 221Z, 222

Structure Elucidation                                                                         Chem. 228, 326

Advanced Organic Chemistry                                                          Chem. 323

Advanced Organic Chemistry                                                          Chem. 321

Advanced Organic Chemistry III                                                      Chem. 523

Advanced Organic Chemistry IV                                                      Chem. 524

Organic Photochemistry                                                                   Chem. 471

Phosphorus Chemistry                                                                     Chem. 471

Synthetic Strategies                                                                          Chem. 471

Directed Studies (Variety of Topics)                                             Chem. 397, 497

Introductory Organic Laboratory                                                      Chem. 121L, 122L,

Organic Preparations                                                                        Chem. 275, 327R

Seminar                                                                                             Chem. 591, 791

Molecular Modeling                                                                           Chem. 725

Drug Discovery                                                                                 Chem. 729R



Kottmeier,Steven                                                                               Malone, Thomas

Grimm, Susan                                                                                   Pacetti, Steven

Russell,Holly                                                                                     Karhalios, Peter

Arbiser, Jack*                                                                                   Flannagan, Nancy

Magruder, G. Brock                                                                          Brown, Morris

Puleo, Robert                                                                                    Lovitt, Etta*

Wugalter, Barbara                                                                             Kezar, Edwin

Rocklin, Mark                                                                                    Yasman, Jeffrey

Short, James                                                                                     Markiewicz, William

Cohen, Robert                                                                                   Santiesteban, Hector*

Paty, Phillip*                                                                                       Secosan, Craig

Jamison, Charles                                                                              Barnum, Christopher

Grossman, Judy*                                                                              Powell, Gwendolyn*

Ginsberg,Steven*                                                                              Whitworth, Terry

Jackson, Karen                                                                                 Bernstein, Duane

Reiner, John                                                                                      Phillips, Preston*

Lee, Donna                                                                                        Bretan, Amy

Fivush, Adam*                                                                                   Carmicheal, Elizabeth*

Cronin, Christopher                                                                           Lee, James M.*

Lloyd, Aaron                                                                                      Pentaleri, Michael*

Dhruv, Nikhita                                                                                   Howard, Nancy

Ginn, Neil                                                                                           Granock, Howard

Javier, Carolyn                                                                                  Livingston, Jenny

Sreeram, Gautam                                                                             Heiss, Aaron

Ellison, Margaret                                                                               Chaiyachati, Sukit

Surattamont, Surichya                                                                      Reece, Gerry

Bien, Jeff                                                                                           Petty, Sandra

Morin, Gregory*                                                                                Underwood, Robert

Lobben, Paul                                                                                     Zimring, James

Nettles, James*                                                                                 Denius, Theodore

Jordan, Briton                                                                                    Khoram, Aram Rodney

Daniels, Sam                                                                                     Hollings, Darius

Ko, Huei-Huei                                                                                    El Diery, Mark

Van Dinh, Long                                                                                  Lyalikov, Vladimir

Okor, Mamehri                                                                                  Taghechian, Shaya

Torabi-Parizi, Parizad                                                                       Graham, Abigail

Lines, Daniel                                                                                      Raja , Shreya

Jia, Jenny                                                                                          Ryder, Chris

Borland, Johnathan                                                                           Wojdylo, Julia

Dua, Shiv                                                                                           Beckett, Allison

Sruti Gupta                                                                                        Andrew Navia

Catherine Urbano

*BS/MS program.



Name                                          Degree                               Highest Degree or Current Location

Period                                                                                    Thesis Title


Santiesteban, Hector                                                             M.D.-Ph.D., Emory Univ. Medical

1976-1977                                  M.S.                                    School

New Synthetic Transformations Involving Phenyl Selenide Anion.


Powell, Gwendolyn                                                                M. D. – Univ. of Miami Medical

1976-1977                                  M.S.                                    School

.                                                                                             Director of Health Affairs, Glaxo, Inc.

Experiments Directed Toward the Synthesis of 7,7-Dimethylnorbornadiene.


Lovitt, Etta                                                                              M.D., Emory Univ.Medical School

1977-1978                                  M.S.                                    An Investigation of the Reactions of Singlet Oxygen with Non-conjugated Interacting Dienes.


Paty,Phillip                                                                             M.D.-Ph.D., Stanford Univ. Medical

1977-1978                                  M.S.                                    School

Synthetic Applications of Trimethylsilylphenylselenide.


Williams, Richard                                                                   New England Nuclear

1976-1979                                  M.S.                                    Photooxygenation Reactions in Perfluorohydrocarbon Media.Phenylselenenly Enoates.


Zima, George                                                                        Tennessee Eastman

1976-1980                                  Ph.D.                                  Modern Organoselenium Chemistry.


Ginsberg, Steven                                                                  M.D., Downstate Medical Center

1979-1980                                  M.S.                                    Application of Diethyltrimethylsilyl Phosphite as a Reagent for Umpolung.


Grossman, Judy                                                                   Molecular Design, Ltd.

1979-1980                                  M.S.                                    An Investigation of Reactions of Anions with Selenium Metal.

1980-1985                                  Ph.D.                                  Theoretical Explorations of Diastereoselectivity, Reactivity and Reaction Trajectories


Barnum, Christopher                                                             Dupont

1977-1981                                  Ph.D.                                  1. New Organoselenium Methodology. 2. Diels-Alder Reactions of Cross-Conjugated Dienones.


Reyes, Augustin                                                                    Augustin W. Reyes Perfume Co.

1979-1981                                  M.S.                                    Synthesis and Reactions of Phenylselenenly Enoates.


Sunay, Ustun                                                                         Atlanta

1979-1984                                  Ph.D.                                  1. New Synthetic Methodology. 2. Exploratory Studies Directed Towards The Total Synthesis of Forskolin.


Arbiser, Jack                                                                         Enders Children’s Hospital

1982-1983                                  M.S.                                    1. A Simple, Inexpensive Procedure for the Large-Scale Production of Quinones. 2. Synthesis of Selenated Heterocycles


Luce, Hudson                                                                        Ph, D., Univ. of Fla.,

1981-1982                                  M.S.                                    1. A Study in the Selective Enolization of a Series of 10-Methyl-3-Decalones. 2. Conformational Energies of a Series of Allylic and Homoallylic Alcohols.



Waykole, Liladhar                                                                  Sandoz Research Institute

1980-1984                                  Ph.D.                                  Carbanion Reactions: Mechanisms and New Methodology.


Ott, Walter                                                                             Lecturer – Emory Univ.

1981-1986                                  Ph.D.                                  Methodologies Toward the Total Synthesis of Pallescensin A and Model Studies of the Quassinoid Bruceantin.


Jamison, W. Charles                                                             Patent Attorney

1981-1987                                  Ph.D.                                  1. Approaches to the Total Synthesis of the Diterpene Marrubiin. 2. Ligand Assisted Nucleophilic Addition. 3. Coal Processing in a Non-dissolving Medium.


Dunams, Tambra                                                                  Tennessee Valley Authority

1982-1988                                  Ph. D.                                  1. New Methods for the Synthesis of Substituted Furans. 2. Hydrophobicity Effects in Diels-Alder Reactions. 3. Approaches to the Synthesis of Lasalocid A Analogs.







Hoekstra, William                                                                   R. W. Johnson Pharmaceutical

1982-1986                                  Ph.D.                                   Research Inst.

  1. New Organoselenium Methodology. 2. Studies Directed Towards The Total Synthesis of the Natural Product Forskolin.



Solomon, Mark                                                                      Mobay, Inc.

1983-1988                                  Ph.D.                                   1. A Mechanistic Study of the Alkylation of Selenium-Substituted Enolates. 2. Ligand Assisted Nucleophilic Additions:  Scope and Limitations.


McCormick, Michael                                                              Lecturer, Department of Chemistry,

1983-1993                                  M.S.                                    Emory University


Stephens, Julie                                                                      Theragenics Corporation

1983-85                                      M.S.                                    Trajectories of Proton Transfer Reactions: Proton Transfer at an Acute Angle


Monahan, Robert                                                                   MD, Columbus, GA

1984-1988                                  Ph.D.                                   1. Stereochemistry of Electrophile-Induced Cyclizations. 2. An Investigation of the Intramolecular Alkoxypalladation Carbonylation Reaction. 3. Synthesis of Phorbol-13-O-(3′-Dansylamino)-tetradecanoyl Acetate.


Brown, David                                                                         Hoechst-Celanese

1982-1986                                  Ph.D.                                  1. New Oxidative Rearrangement Methodology. 2. Mechanistic Studies of Quinone Diels-Alder Reactions.


Nimkar, Sanjay                                                                      University of Kansas

1985-1990                                  Ph.D.                                   1. Syntheses of Sphingosine Analogs and Its Derivatives.  Stereoselective Syntheses of Sphingosines. 2. Approaches Toward the Total Syntheses of Royleanaone and Taxodione.


Menaldino, David                                                                   VP of Research, F.O.B. Synthesis,

1986-92                                      Ph.D.                                  Atlanta

Asymmetric Syntheses of Amino Alcohols as Bioactive Compounds.



Sisti, Nicholas                                                                        Napro Biopharmaceuticals

1986-1987                                  M.S.                                    Phospholipids:  Form, Function and Synthesis.


Sperka, James                                                                      Masters Program in Chemistry,

1986-1994                                  M.S. (deceased)                Emory University


Swiss, Kevin                                                                          Postdoctoral Fellow; University of

1987-1991                                  Ph.D.                                  Illinois

Mechanism and Synthetic Methodology of the Ligand Assisted Nucleophilic Addition Process.


Mohan, Julie                                                                          Glaxo, Inc.

1987-1989                                  M.S.                                    1. Factors Affecting Mono- and Di-additions of Carbanions to Quinones and Related Species. 2. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation.


Hager, Michael                                                                      F.O.B. Synthesis, Atlanta

1987-1993                                  Ph.D.                                  Approaches to 3′-Substituted 2′,3′-Dideoxynucleosides Starting from Non-Carbohydrate Precursors:  The Synthesis of 3′-Azido-3′-deoxythymidine and 3′-Fluoro-3′-deoxythymidine.


Hinkley, William                                                                      Glaxo Wellcome, Inc.

1987-1991                                  M.S.                                    1. Intramolecular Diels-Alder Reaction Rate Enhancement Due to Ethylene Glycol Solvation Effects. 2. Synthesis of Dihydrothiazine Oxide Fungicieds Via Intramolecular Hetero Diels-Alder Methodology. 3. Cuprate Additions to Quinol Alkoxides.


Strange, Luise                                                                       Dekalb College

1988-1992                                  M.S.                                    1. Review of Literature Involving the Use of Enzymes in Organic Synthesis and Utilization of Organic Solvents to Improve Enzymatic Reactions. 2. Application of Enzymatic Technology Toward Specific Target Molecules Related to the Antiviral Compounds 2’,3’-Dideoxy-3’-thiacytidine and 2’,3’-Dideoxy-5-fluoro-3’ thiacytidine.






Morin, Gregory                                                                      Doctoral Prog in Chemistry, Notre

1991-1992                                  M.S.                                    Dame University

A Study of the Stereochemical Consequences of Nucleophilic Michael Additions to a g-Butenolide Directed Towards the Synthesis of Novel Nucleosides.


Wurster, Julie                                                                        Postdoctoral Fellow; U. of California,

1988-1994                                  Ph.D.                                  Irvine

.                                                                                              Stereoselective Metonds For 2’, 3’-Dideoxynucleoside Preparation:  Purine Nucleoside Glyosylation and 3’-Functionalization of Nucleoside Precursors



Geisler, Victoria J.                                                                 Professor and Chair; Department of 1984-1991        Ph.D.   Chem.

West Georgia College

Part I. Actinomysin D-Inspired DNA Binding

Compounds. Part 2. Evaluation of the Role of

Intramolecular Hydrogen-Bonding and PKa of Long-Chain Bases on the Inhibition of Protein Kinase C.


Wilson, Larry                                                                           Proctor and Gamble

1988-1992                                     Ph.D.                                 Pharmaceuticals.

A Stereoselective Approach to 2′,3′-Dideoxynucleosides.  Stereoselective Sulfenylation and Nitrogen Glycosylation Reactions.


Jones, Deborah                                                                      Postdoctoral Fellow; Yale University

1989-1994                                     Ph.D.                                 Site Head and Director Cheminformatics, GSK

Theoretical Investigations Aimed At Elucidating the Origins of Stereoselectivity A Three Case Study


Mills Crane, Heidi                                                                    Sphinx Pharmaceutical

1990-1993                                   M.S.                                    Stereoselective Syntheses and Stereochemical Evaluation of Various Sphingolipids



Spurling, Travis                                                                       Novel Approaches Towards to

1990-1997                                     Ph.D.                                 Treatment of

HIV Infection


Gall, John                                                                                EPA / Dekalb College

1990-1993                                   M.S.                                    Part I:  Review of the Literature dealing with the Syntheses of 2’,3’-dideoxy and 2’,3’-Dideoxy-2’,3’-Didehydronucleosides.

Part II:  Attempted Syntheses of 2’,3’- Didreoxypyrimidines via Intramolecular N-Glycosylation


Xia, Jianhui                                                                              Doctoral Program, Carnegie-Melon

1991-1995                                   M.S.                                    University





Voronkov, Michael                                                                  Postdoctoral Fellow;

1991-1997                                   Ph.D.                                  Part I: Synthesis of Novel Nucleoside Analogues as Potent Anti-HIV Agents: Part II: Preparation and Synthetic Studies of Novel Taxol Analogues


Goh, Jane                                                                               Postdoctoral Fellow;

1992-1997                                   Ph.D.                                  Diastereoselective Reactions of

-Dibenzylamino Carbonyl Compounds


Captain, Laura                                                                        Postdoctoral Fellow; UNC, Chapel

1992-1997                                   Ph.D.                                  Hill

Part I: Diastereroselective Conjugate Addition Reactions to a Novel 3-Ketoacrylate System for the Synthesis of HIV-1 Protease Inhibitors. Part II: A Novel Approach to Taxol Semisynthesis Utilizing Oxygen-Substituted Ketenes


Johnston, Lisa                                                                       Unknown

1994-1998                                  Ph.D.


McAtee, Jeff                                                                          Postdoctoral Fellow; Scripps

1994-1999                                  Ph.D.


Xia, Xiaoyang                                                                         Alanex Corporation

1992-1997                                  Ph.D.                                  Part I: Stereocontrolled Synthesis of [beta]-2’-Deoxypyrimidine Nucleosides through Intramolecular Glycosylations; Part II: Minireceptor Enzyme Active Sites of HIV Protease




Guan, Ningning                                                                      Doctoral Prog.; Biochemistry, Emory

1995-1997                                  M.S.                                    University

Newer Methodologies for the Stereoselective Synthesis of 2’, 3’ – Dideoxynucleoside Analogues


Vo, Hoang Minh                                                                     Part I: Novel Approaches Towards

1996-1998                                  M.S.                                    the Synthesis of Hydroxyethylene Isosteres, a Class of HIV-Protease Inhibitors; Part II: Efficient and Stereoselective O-Glycosylation of 1-Acy-2-Sulfenyl-Dideoxy-Ribofuranoses Catalyzed by Cerium (III) Chloride


Cornett, Ben                                                                          Eli Lilly

1997-2002                                  Ph.D.                                  Solution Conformational Studies of

Microtubule-Stabilizing Agents


Curfman, Chris                                                                      Patent Attorney, Needle and

1996-2000                                  Ph.D.                                  Rosenberg, Georgia State School of Law

Synthetic Strategies Toward

Omega-Functionalized Sphingolipid Analogs


Byun, Kiyoung                                                                       Faculty Fellow, Boston University

1997- 2001                                 Ph.D.                                  Computational Studies Toward the

Design and Synthesis of Novel

Inhibitor Compounds


Ferstl, Eva                                                                             Pharmacia, Milan, Italy,

1998-2000                                  Ph.D.                                  Part I: Thiazolidine-2-Thione

Induced Diastereoselective Addition of Enolates to Imines. Part II: Novel Curcumin Analogs as Suppressors of Tumor Growth and Angiogenesis


Young, Josephine                                                                 US Patent and Trademark Office,

1998-2000                                  Withdrew                            Washington, DC


Lakdawala, Ami                                                                     Glaxo SmithKline

1999-2003                                  Ph.D.                                              Part I.  Structure & Dynamics of beta-Amyloid

Fibrils Part II.  Design of Taxol (Paclitaxel) Analogs and Predictive Models; Design pf Measles Virus Inhibitors; Conformational Analysis of alpha-Helical Mimics





Ambhaikar, Narendra                                                            Postdoctoral Fellow, Scripps

1999-2003                                  Ph.D.                                              Thiazolidine-2-thione Directed Diastereoselective

Additions of Chlorotitanium Enolates to Aldimine Derivatives


Leong, Lynette                                                                      Pharmacopeia, Philadelphia

1999-2001                                  M.S.


Thepchatri , Pahk                                                                  MLSCN, Emory University;

2000-2005                                  Ph.D.                                  Identification of Conformational Ensembles in Solution: Potential Source of Bioactive Candidates


Pruett, Sarah                                                                         Yerkes Regional Primate Center,

2000-2006                                  Ph.D.                                  Emory.

Biological Mass Spectrometry of Sphingolipids in Drug Discovery and Development;


Mao, Shuli                                                                              EIDD

2000-2005                                  Ph.D.                                  Synthesis and Anti-HIV Activity of Novel

Cyclobutyl Nucleoside Analogs;



Herold, Marike                                                                       Postdoctoral Fellow, Cambridge

2001-2005                                  Ph.D.                                  University, UK

Diastereoselective One-Pot Synthesis of Azetines and b-Lactams Starting from Nitriles; Part II Novel Curcumin Analogs as Antitumor Agents


Itta Bluhn-Chertudi                                                                 Scynexis, Research Triangle;

2001-2005                                  M.S.                                    Methodology for the remote induction of asymmetric hydrocyation in a,b-unsaturated ketones


Dougherty, Ann                                                                     Postdoctoral Fellow, Emory

2002-2007                                  Ph.D.                                  University

Part 1. Synthesis Pyrrolidine Diol Sphongolipid Analogs and Evaluation of their Biological Activity Part 2. Synthesis of Pre-hemibrevetoxin B’ Polyene: Applications in the Biosynthesis of the Brevetoxins





Fang, Xingang                                                                         Adjunct Professor, U. of West FL

2002-2008                                   Ph.D.                                  Synthesis and Anti-Viral Activity

of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside



Kurtkaya, Serdar                                                                    System Analyst, MUSC

2002-2005                                   M.S.                                    “3JC=CCH Karplus Equation And 3JFCCF Karplus Curve Derivation With The Help Of Computational Chemistry To Explain Unexpected NMR Coupling Data In Organic And Biological Systems & Structure-Activity Relationship Studies On Curcumin Analogs”


Moore, Rhonda                                                                       Postdoctoral Fellow, U. of Colorado

2002-2006                                   Ph.D.                                  Synthesis and Biological Evaluation of Novel

Phenyl Epothilone Analog and Oxazolidinone Directed Diastereoselective Synthesis of b-Amino Carbonyl Derivatives



Bluemling, Greg………………………………………                         Principle Scientist, EIDD

2002-2010                                   Ph.D.                                  Part I: Synthesis of Cyclobutyl

Nucleoside Analogs That Mimic AZT

for Inhibition of the K65R HIV-1

Reverse Transcriptase Mutant

Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation


Malick, Sanna…………………………………………                         Law School

2003-2006                                   M.S.                                    Part 1. Synthesis of Curcumin Analogs and their Biological Evaluation on Microtubules and Actin in Prostate Cancer Cells

Part 2. Decomposition Studies of Curcumin Analog UBS 109 Using Mass Spectrometry

Part 3. Mass Spectrometry Study of CXCR4 Antagonist WZ40MS








McNevin, Chris……………………………………….                         Part 1. Stereoselective Synthesis of

2003-2008                                   Ph.D………..                         Quaternary Center Bearing Azetines

……………….                         and B-Amino Acid Derivatives

……………….                         Part 2. Natural and

……………….                         Enantiomeric Progesterone

……………….                         Analogues for the

……………….                         Treatment of Traumatic Brain Injury


Yong Feng, (Lucy) Li……………………………….                         Part 1: Synthesis and Anti-HIV

2003-2008……………………………. Ph.D                                   Activity of Novel Cyclobutyl

…………………………………………….                                            Nucleoside and Nucleotide


……………….                         Part 2: Synthesis of Fluorescent

……………….                         Nucleoside Analogs

……………….                         Part 3: Synthesis of Abacavir


Alcaraz, Ana………………………….                                            Computational Studies of Ligand-2003-2009  Ph.D.   Protein Interactions Part I: The

…………………………………………….                                            T-Taxol Conformation

…………………………………………….                                            Part II: Elucidating Interdependent

…………………………………………….                                            Binding Sites on Tubulin


Prussia, Andrew……………………………………..                         ORISE Fellow, CDC

2003-2009                              …. Ph.D..                                 Part I: Measles virus entry into cells and the

……………………………………………………………..                         inhibition of fusion and replication Part II: The nature of cyclostreptin’s interaction with microtubules


Jogalekar, Ashutosh………………………………..                         Molecular Modeler/Scientist,

2003-2009 …………………………… Ph.D.                                  Ensemble Therapeutics

……………………………………………………………..                         1. Conformational Analysis of

……………………………………………………………..                         Bioactive Molecules in Solution

……………………………………………………………..                         2. Design of Selective

……………………………………………………………..                         Inhibitors for Cyclin-Dependent

……………………………………………………………..                         Kinase 7



Geballe, Matt                               ……………….                         OpenEye Scientific

2003-2008                                   Ph.D………..                         Part I: Structure and Function in the

……………….                         NMDA Ligand Binding Domain.

……………….                         Part II: Comparison of

……………….                         Paclitaxel Analogs through

……………….                         Molecular Dynamics Simulation;

……………….                         Solution Conformations

……………….                          of Cyclic Peptides.


Wright, Suzanne                         ……………….                         Withdrew



Zhan, Weiqiang                           ……………….                         Eli Lilly

2003-2008                                   Ph.D………..                         Design, Synthesis and Biological

……………….                         Evaluation of C6-C8 Bridged

……………….                         Epothilone Analogs and Discovery of

……………….                         Small Molecule CXCR4


Becnel-Davis, Kimberlynne        ……………….                         Associate at Kilpatrick, Townsend &

2003-2008                                   Ph.D………..                         Stockton

……………….                         Synthesis of Cyclobutyl Nucleoside

……………….                         and.Nucleotide Analogues as HIV-1

……………….                         Reverse Transcriptase Inhibitors


Mosely, Cara                              ……………….                         Pabst Patent Group LLP

2004-2009                                   Ph.D………..                         Design, Synthesis and Biological Evaluation of

……………….                         Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists Towards the Treatment of Neurodegenerative Diseases


Murray, Ernest                            ……………….                         Medical School

2004-2008                                   M. S…………                         College of Charleston


Neuman, Annette                        ……………………………………. Part I: Synthesis of 2′-Fluoro-2′,3′-

2004-2012                                   Ph.D. …………………………… Dideoxynucleosides asInhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV ReverseTranscriptase


Baillie, Mark                                 ……………….                         Towards the Development of

2005-2011                                   Ph.D………..                         Non-Toxic Therapeutics in the Fight

……………….                         Against Cancer

……………….                         Postdoctoral Fellow, Switzerland


Hu, Haipeng                                ……………….                         Validation of Receptor-Based Drug

2005-2011                                   Ph.D………..                         Design and Applications in the Study of IKKs, Truncated Taxane and LRH-1

……………….                         Postdoctoral Fellow, Emory


Jiang, Yi                                      ……………….                         Design, Synthesis and Biological

2005-2010                                   Ph.D………..                         Evaluation of C4-C9 Bridged

……………….                         Epothilone Analogs


Kim, Mi-Sun                                 Ph.D………..                         Identification of modulators for the

2005-2012                                   ……………….                         SREB(Super Conserved Receptor Expressed in Brain) family


Purcell, Jamie                             ……………….                         Withdrew

2006-2007                                   ……………….


Truax, Valarie                             ……………….                         Design, Synthesis, and Biologic

2006-2014                                   Ph.D………..                         Evaluation of Tetrahydroisoquinoline-based CXCR4 Modulators


Santangelo, Rose                                                                   Chapter 1: Design and Synthesis of

2006-2012                                     Ph.D.                                 GluN1/GluN2B Selective NMDA Receptor Antagonists for the Potential Treatment of Neurodegenerative Diseases; Chapter 2: Design, Synthesis, and Biological Evaluation of First-in-Class GluN2C/2D-Selective NMDA Receptor Potentiators


Zimmerman, Sommer                                                             Design, Synthesis, and Biological

2008-2013                                   Ph.D.                                  Evaluation of Subunit-Selective N-Methyl- D-Aspartate Receptor Modulators


Shi, Qi                                                                                     Computer-Assisted Drug Discovery

2008-2014                                   Ph.D.                                  Part I: Design, Development,

Validation and Application of

FRESH, a Novel In-Silico

High-throughput Screening Program

Part II: Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anticancer Properties

Part III: Development of 2nd Generation NAMFIS Software Program by Java


Acker, Tim                                  ……………….                         Structural Determinants of Activity,

2008-2013                                   Ph.D. ………                         Mechanism and Structure Activity Relationships of Novel GluN2C/D Subunit Selective Antagonists of the N-methyl-D-Aspartate Receptor


Miller, Eric                                                                               Postdoc, Emory

2009-2015                                   Ph.D.                                   Discovery of CF2-Enigmol, a

Fluorinated Enigmol

Ph.D.Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties


Katzman, Brooke                                                                    Postdoctoral Fellow, Mayo Clinic

2009-2014                                   Ph.D.                                  Part 1: Design, Synthesis, and

Biological Evaluation of a Novel

Class of Allosteric Modulators of N

Methyl-D-Aspartate Receptor


Part 2: Discovery of Novel

Tetrahydroisoquinoline (THIQ)-

Based CXCR4 Antagonists and

Conformational Analysis of

Structurally Similar CXCR4 Antagonists


Strong, Katie                               ……………….                         Doctoral Program in Chemistry, 2009-present          Ph.D. (projected)                                                            Emory


Baldwin, Patrick                                                                      Postdoc, University of Maryland,

2010-2014                                   Ph.D.                                  School of Medicine

Development of Monocarbonyl

Curcumin Analogues to Treat

Tuberculosis and Cancers


Giesler, Kyle                               ……………….                         Doctoral Program in Chemistry, 2012-present          PhD (projected)                                                              Emory


Jing, Yao                                     ……………….                         Doctoral Program in Chemistry, 2012-present          PhD (projected)                                                              Emory


Prosser, Tony                             ……………….                         Doctoral Program in Chemistry, 2012-present          PhD (projected)                                                              Emory


Jones, Matthew                                                                      Doctoral Program in Chemistry, 2013-present                                      Ph.D. (projected)            Emory


Epplin, Matt                                                                             Doctoral Program in Chemistry, 2014-present                                      Ph.D. (projected)            Emory


















Johnston, Judy (deceased)                                                   Dekalb College

1977-1978                                                                               Organoselenium Chemistry.


Saindane, Manohar                                                                 Sterling-Winthrop

1980-1984                                                                               Organoselenium Chemistry,Diels-Alder Chemistry, Total Synthesis.


Hoekstra, William                                                                    R. W. Johnson Pham. Res. Inst.

1987-1988                                                                               Synthesis of b-Lactamase Inhibitors.


Sunay, Ustun                                                                          Consultant, Emory University

1987-1988, 2003-2011                                                           Synthesis of Potential Anti-Leukemic Agents.



Yeola, Suresh                                                                         Vanderbilt University

1987-1992                                                                               Synthesis of Potential Anti-Leukemic Agents.


Choi, Woo-Baeg                                                                      F.O.B. Synthesis, Atlanta

1989-1991                                                                               Antiviral Synthesis


Soria, Jose                                                                              Emory University, Lecturer

1990-1995                                                                               Synthesis of Potential Antiviral Agents


Hoong, Lee                                                                             AtheroGenics, Inc.

1990-1995                                                                               Synthesis of Potential Antiviral Agents


Lagu, Bharat                                                                           Synaptic Pharmaceutical

1991-1994                                                                               Corporation

Synthesis of Protein Kinase C Inhibitors


Nevins, Neysa                                                                        Glaxo-SmithKline, Philadelphia

1994-1999                                                                               Molecular Modeling


Sisti, Nicholas                                                                         SmithKline Beecham

1992-1993                                                                               Pharmaceuticals

Synthesis of Potential Antiviral Agents


El-Kattan, Yahya                                                                     University of South Alabama

1992-1994                                                                               Synthesis of Chemical Sensitizers for Boron Neutron Capture Therapy


Wilson, Timothy                                                                      Ciba-Geigy

1993-1995                                                                               Synthesis of Taxol Analogues



Wey, Shiowiyi                                                                          NitroMed, Inc.

1993-1997                                                                               Synthesis of Antiviral Nucleosides


Alexander, Christopher                                                           College of Charleston

1993-1995                                                                               Sphingolipid analogue synthesis


Bushnev, Anatoliy                                                                   Emory University

1995-present                                                                          Sphingolipid analogue synthesis


Beall (Keffer), Jennifer                                                            New Jersey



Kasdorf, Krista                                                                        Florida



Swiss, Kevin                                                                           Connecticut



Venkatesan, Hari                                                                    Johnson & Johnson, La Jolla, CA

1995-2000                                                                               Research Chemist


Zhang, Dawei                                                                          Alanex Corporation



Martin Bouygues                                                                     FOB Synthesis



Joubert, Muriel                                                                        Returned to France



Sun, Aiming                                                                             Emory University

2001-2005, 2011-2014                                                           EIDD


Altas, Yesim                                                                            Altiris



Yu, Xiaochun                                                                           Returned to China



Saen-oon, Suwipa



Rheinecker, Jaime



Chris van der Westhuyzen



Patrick Demana




Pieter Burger

2009-2010, 2013-present


Michael Mckay



Stephen Pelly



Jason Holt



Terry Moore



Huanyu Zhao



Bryan Cox



Alexandra Orchard



Gary Brandt




Madhari Dasari

Michelle Kim




Edgars Jec



Robert Wilson



Chris Butch



Eric Miller




  1. Katzman, B.; Perszyk, R.; Yuan, H.; Altas Tahirovic, Y.; Sotimehin, A.; Traynelis, S.; Liotta, D. A novel class of negative allosteric modulators of NMDA receptor function.Bioorg. Med. Chem. Lett., 2015, 25:5583-5588.
  2. Cox, B.; Mehta, A.; DiRaddo, J.; Liotta, D.; Wilson, L.; Snyder, J. Structural analysis of CXCR4 –Antagonist interactions using saturation-transfer double-difference NMR. Biochem and Biophysical Research Communications, 2015http://dx.doi.org/10.1016/j.bbrc.2015.08.084.
  3. DiRaddo, J.; Miller, E.; Bowman-Dalley, C.; Wroblewska, B.; Javidnia, M.; Grajkowska, E.; Wolfe, B.; Liotta, D.; Wroblewski, J. Chloride is an agonist of group II and III metabotropic glutamate receptorsMol Pharmacol , 2015 ,88:450-459.
  4. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo by using Cy5.5-labeled factor VIIa and anti-tissue factor antibodyJ. Drug Targeting201523(3): 257-265.
  5. Cox, B.; Prosser, A.; Sun, Y.; Li, Z.; Lee, S.; Huang, M.; Bond, V.; Snyder, J.; Krystal, M.; Wilson, L.; Liotta, D.Pyrazolo-Piperidines Exhibit Dual Inhibition ofCCR5/CXCR4 HIV Entry and Reverse TranscriptaseACS Med. Chem. Lett.2015, 6: 753-757.
  6. Zhao, H.; Prosser, A.; Liotta, D.; Wilson, L. Discovery of novel N-aryl piperazine CXCR4 antagonistsBioorg. & Med. Chem. Lett. 2015,  in press.
  7. Yuan, H.; Myers, S.; Wells, G.; Nicholson, K.; Swanger, S.; Lyuboslavsky, P.; Tahirovic, Y.; Menaldino, D.; Ganesh, T.; Wilson, L.; Liotta, D.; Snyder, J.; Traynelis, S.Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects. Neuron., 201585: 1305-1318.
  8. Baldwin, P.; Reeves, A.; Powell, K.; Napier, R.; Swimm, A.; Sun, A.; Giesler, K.; Bommarius, B.; Shinnick, T.; Snyder, J.; Liotta, D.; Kalman, D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.Eur. J. of Med. Chem., 2015, 92: 693-699.
  9. Khatri, A.; Burger, P.; Swanger, S.; Hansen, K.; Zimmerman, S.; Karakas, E.; Liotta, D.; Furukawa, H.; Snyder, J.; Traynelis, S. Structural Determinants and Mechanism of Action of GluN2C-selective NMDA Receptor Positive Allosteric Modulator.Mol. Pharmacol., 201486:548–560.
  10. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Liotta, D.; El-Rayes, B.; Brat, D.; Snyder, J.; Shoji, M. Tumor Angieogenesis Therapy Using Targeted Delivery of Pacclitaxel to the Vasculature of Breast Cancer Metastases.J. Drug Deliv., 2014.
  11. Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody.J. Drug Target. 2014, 16:1-9.
  12. Strong, K.; Jing, Y.; Prosser, A.; Traynelis, S.; Liotta, D. NMDA receptor modulators: an updated patent review (2013-2014)Expert Opin. Ther. Patents.,201424(12), 1349-1366.
  13.   Zhou, T.; Ye, L.; Bai, Y.; Sun, A.; Cox, B.; Liu, D.; Li, Y.; Liotta, D.; Snyder, J.; Fu, H. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: A novel curcumin analog. PLoS One., 2014,9 (9), e107876
  14. DiRaddo, J.; Miller, E.; Hathaway, H.; Grajkowska, E.; Wroblewska, B.; Wolfe, B.; Liotta, D.; Wroblewski, J. A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J. Pharmacol.Exp. Ther., 2014, 349(3), 373–382.
  15. Hu, H.; Mao, S.; Bugrysheva, J.; Pruett, S.; Liotta, D.; Scott, J.; Snyder, J. Group A streptococcus inhibitors by high-throughput virtual screening.Eur. J. of Med. Chem.201482, 120-126.
  16. Cox, B.; Prosser, A.; Katzman, B.; Alcaraz, A.; Liotta, D.; Wilson, L.; Snyder, J. Anti-HIV Small Molecule Binding in the Peptide Subpocket of the CXCR4:CVX15 Crystal Structure.Chem. BioChem. 201415(11), 1614-1620.
  17. Krumm S. A.; Yan, D.; Hovingh, E.; Evers, T. J.; Enkirch, T.; Prabhakar R.; Sun, A.; Manohar T.; Arrendale, R.; Painter, G.; Liotta, D.; Natchus, M.; von Messling, V.; Plemper, R. An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model. Sci. Transl. Med2014,6(232), p. 232ra52.
  18. Zimmerman, S.; Khatri, A.; Garnier-Amblard, E.; Mullasseril, P.; Kurtkaya, N.; Gyoneva, S.; Hansen, K.; Traynelis, S.; Liotta, D. Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators.J. Med. Chem2014, 57 (6), 2334-2356.
  19. Prosser, A.; Liotta, D. One-pot transformation of esters to analytically pure ketones: methodology and application in process developmentTet. Lett. 2014.Article in Press.
  20. Truax, V.; Zhao, H.; Katzman, B.; Prosser, A.; Alcaraz, A.; Saindane, Manohar T.; Howard, R.; Culver, D.; Arrendale, R.; Gruddanti, P., Taylor J.E., Natchus, M.; Snyder, J.; Liotta, D.; Wilson, L. Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2013, 4(11), 1025- 1030.
  21. Acker,T.; Khatri, A.; Vance, K.; Slabber, C.; Bacsa, J.; Snyder, J.; Traynelis, S.; Liotta,
  22. Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Page 39 Class of GluN2C/GluN2D Selective Antagonists. J. Med. Chem. 2013, 56(16), 6434- 6456.
  23. Moore, T.; Sana, K.; Yan, D.; Krumm, S.; Thepchatri,P.; Snyder, J.; Marengo, J.; Arrendale, R.; Prussia, A.; Natchus, M.; Liotta, D. Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy. ACS Med. Chem. Lett. 2013, 4(8), 762-767.
  24. Santangelo Freel, R.; Ogden, K.; Strong, K.; Khatri, A.; Chepiga, K.; Jensen, H.; Traynelis, S.; Liotta, D. Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors. J. Med. Chem. 2013, 56(13), 5351-5381.
  25. Brown, A.; Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Snyder,
  26. Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors That Mediate Anticancer Properties. J. Med. Chem. 2013, 56(9), 3456-3466.
  27. Moore, T.; Sana, K.; Yan, D.;Thepchatri, P.;Ndungu, J.;Sandaine, M.; Lockwood, M.; Natchus, M.; Liotta, D.;Plemper, R.; Snyder, J.; Sun, A. Asymmetric synthesis of host-directed inhibitors of myxovirus. Beilstein J. Org. Chem. 2013, 9(23), 197-203.
  28. Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Brown, A.; Snyder,
  29. Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties. J. Med. Chem. 2013, 56 (9), 3456-3466.
  30. Kim, J.; Wang, L.; Li, Y.; Becnel, K.; Frey, K.; Garforth, S.; Prasad, V.; Schinazi, R.; Liotta, D.; Anderson, K. Pre-steady State Kinetic Analysis of Cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIC-1 transcriptase. Bioorg. Med. Chem. Lett. 2012, 22(12), 4064-4067.
  31. Hassam, M.; Basson, A.; Liotta, D.; Morris, L.; van Otterlo, W.; Pelly, S. Novel Cyclopropyl- Indole Derivatives as HIV Non-Nucleoside Reverse Transctiptase Inhibitors. ACS Med. Chem. Lett. 2012, 3(6), 470-475.
  32. Guthrie, D.; Stein, D.; Liotta, D.; Lockwood, M.; Sayeed, I.; Atif, F.; Arrendale, R.; Reddy, P.; Evers, T.; Marengo, J.; Howard, R.; Culver, D.; Natchus, M. Water-Soluble Progesterone Analogues are Effective,Injectable Treatments in Animal Models of Traumatic Brain Injury. ACS Med. Chem. Lett., 2012, 3(5), 362-366.
  33. Burger, P.; Yuan, H.; Karakas, E.; Geballe, M.; Furkawa, H.; Liotta, D.; Snyder, J.; Traynelis,
  34. Mapping the binding of GluN2B-selectve N-methyl-D-aspartate receptor negative allosteric modulators. Mol. Pharmacol. 2012, 82(2), 344-359.
  35. Santangelo, R.; Acker, T.; Zimmerman, S.; Katzman, B.; Strong, K.; Traynelis, S.; Liotta,
  36. Novel NMDA Receptor Modulators: An Update. Expert Opin. Ther. Pat. 2012, 22(11), 1337- 1352.
  37. Meyer, E.; Holt,J.; Girard, K.; Baillie, M.; Bushnev, A.; Lapp, S.; Menaldino, D.; Arrendale, R.; Reddy, P.; Evers, T.; Liotta, D.; Galinski, M.; Natchus, M. Sphingolipid Analogues Inhibit Development of Malaria Parasites. ACS Med. Chem. Lett. 2012, 3(1),43-47.
  38. Liang, Z.; Zhan, W.; Zhu, A.; Yoon, Y.; Lin, S.; Sasakim Jan, M.; Klapproth, M.; Yang, H.; Grossniklaus, H.; Xu, J.; Yun, C.; Snyder, J.; Liotta, D.; Shim, H. Development of a Unique Small Molecule Modilator of CXCR4. PLoS one 2012, 7(4), e34038.
  39. Ndungu, J.; Krumm, S.; Yan, D.; Arrendale, R.; Reddy, P.; Evers, T.; Howard, R.; Natchus, M.; Sandaine, M.; Liotta, D.; Plemper, R.; Snyder, J.; Sun, A. Non-nuceoside Inhibitors of the Measles Virus RNA-dependent RNA Polymerase: Synthesis, Structure- Activity Relationships and Pharmacokinetics. J. Med. Chem. 2012, 55, 4220−4230.
  40. Olivera, A.; Moore, T.;Hua, F.; Brown, A.; Sun, A.; Liotta, D.; Snyder, J.; Yoon, Y.; Shim, H.; Marcus, A.; Miller, A.; Pace, T. Inhibition of the NF-signaling pathway by the curcumin analog, 3,5-Bis(,2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int. Immunopharmacol. 2012,12(2), 368-377.
  41. Boyle, G.; Edlin, C.; Li, Y.; Liotta, D.; Morgans, G.; Musondaa, C. Enantioselective Synthesis of the Carbocyclic Nucleoside (–)-Abacavir. Org. Biomol. Chem. 2012, 10(9), 1870-1876.
  42. Makarova, N.; Zhao, C.; Zhang, Y.; Bhosle, S.; Suppiah, S.; Rhea, J.; Kozyr, N.; Arnold, R.; Ly, H.; Molinaro, R.; Parslow, T.; Hunter, E.; Liotta, D.; Petros, J.; Blackwell, J. Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model. PLoS one 2011, 6(4), e18272.
  43. Zhan, W.; Jiang, Y.; Sharma, S.; Brodie, P.; Bane, S.; Kingston, D.; Liotta, D.; Snyder, J. C6-C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle Chem. Eur. J. 2011, 17(52), 4792-14804.
  44. Wilson, L.; Liotta, D.Emergence of small-molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents. Drug Develop. Res. 2011, 72(7), 598-602.
  45. Symolon, H.; Bushnev, A.; Peng, Q.; Ramaraju, H.; Mays, S.; Allegood, J.; Pruett, S.; Sullards, M.; Dillehay, D.; Liotta, D., Merrill, A. Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer. Mol. Cancer Ther. 2011, 10(4), 648-657.
  46. Acker, T.; Yuan, H.; Hansen, K.; Vance, K.; Ogden, K.; Jensen, H.; Burger, P.; Mullasseril, P.; Snyder, J.; Liotta, D., Traynelis, S. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunitselective modulators. Mol. Pharmacol. 2011, 80(5), 782- 795.
  47. Garnier-Amblard, E.; Mays, S.; Arrendale, R.; Baillie, M.; Bushnev, A.; Culver, D.; Evers, T.; Holt, J.; Howard, R.; Liebeskind, L.; Menaldino, D.; Natchus, M.; Petros, J.; Ramaraju, H.; Reddy, P.; Liotta, D. Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer. ACS Med. Chem. Lett. 2011, 2(6), 438-443.
  48. Bushnev, A.; Baillie, M.; Holt, J.; Menaldino, D.; Merrill, A.; Liotta, D. An efficient asymmetric synthesis of enigmols (1-deoxy-5-hydroxysphingoid bases), an important class of bioactive lipid modulators. ARKIVOC (Gainesville, FL, United States) 2010, (8), 263-277.
  49. Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein. J. Phys. Chem. B (2010), 114(2), 1127-1135.
  50. Zhu, A.; Zhan, W.; Liang, Z.; Yoon,Y.; Yang, H.; Grossniklaus, H.; Xu, J.; Rojas, M.; Lockwood, M.; Snyder, J.; Liotta, D.; Shim, H. Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity. J. Med. Chem. 2010, 53 (24), 8556-8568.
  51. Heathcote, D.; Petal, H.; Kroll, S.; Hazel, P.; Periyasamy, M.; Alikian, M.; Kanneganyi, S.; Jogalekar, A.; Scheiper, B.; Bräckow, J.; Siwicka, A.; Pace, R.; Fuchter, M.; Snyder, J.; Liotta, D.; Freemont, P.; Aboagye, E.; Coombes, R.; Barrett, A.; Ali, S. A novel pyrazolo[1,5- a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2 and 9, which demonstrates anti-tumour effects in human tumour xenografts following oral administration. J.Med. Chem. 2010, 53 (24), 8508-8522.
  52. Thomas, S.; Zhao, J.; Li, Z.; Lou, B.; Du, Y.; Purcell, J.; Snyder, J.; Khuri, F.; Liotta, D.; Fu,
  53. Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem. Pharmacol., 2010, 80 (9), 1309-1316.
  54. Xin, T.; Sidell, N.; Mancini, A.; Huang, R.; Wang, S.; Horowitz , I.; Liotta, D.; Taylor, R.; Friedrich, W. Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells. Reprod. Sci. 2010, 17 (10), 931-40.
  55. Mullasseril, P.; Hansen, K.; Vance, K.; Ogden, K.; Yuan, H.; Kyrtkaya, N.; Santangelo, R.; Orr, A.; Le, P.; Vellano, K.; Liotta, D.; Traynelis, S. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 2010, 1 (90).
  56. Suppiah, S.; Sun, C.; Zhang, X.; Bhosle, S.; Rhea, J.; Mays, S.; Parslow, T.; Arnold, R.; Makarova, N.; Liotta, D.; Hunter, E.; Blackwell, J.;Petros, J.; Ly, H.; Molinaro, R. A Novel Transforming Gene Product of the Xenotropic Murine Leukemia Virus-Related Virus. Submitted.
  57. Arnold, R.; Makariva, N.; Osunkoya, A.; Suppiah, S.; Scott, T.; Johnson, N.; Bhosle, S.; Liotta, D.; Hunter, E.; Marshall, F. XMRV infection in patients with prostate cancer; novel serologic assay and correlation with PCR and FISH. J Urol. 2010, 75(4), 755-61.
  58. Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP). J. Phys. Chem. B. 2010, 114(2), 1127-1135.
  59. Li, Y.; Soni, P., Liotta, D.; Liu, L.; Zhang, X.; Lutz, S. Synthesis of fluorescent nucleoside analogs as probes for 2’-deoxyribonucleoside kinases. Bioorg. Med. Chem. Lett. 2010, 20(3), 841-843.
  60. Sun, A.; Lu, Y.; Hu, H.; Shoji, M.; Liotta, D.; Snyder, J. Curcumin analog cytotoxicity against breast cancer cells: Exploitation of a redox-dependent mechanism. Bioorg. Med. Chem. Lett. 2009, 19 (23), 6627-6631.
  61. Bhosle, S.; Suppiah, S.; Molinaro, R.; Liang, Y.; Arnold, R.; Petros, J.; Diehl, W.; Makarova, N.; Blackwell, J.; Petros, J.; Liotta, D.;Hunter, E.; Ly, H. Evaluation of cellular determinants required in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. J. Virol. 2010, 84(13), 6288-96.
  62. Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Res. 2009, 37(13), 4472-4481.
  63. Mosley, C.; Wilson, L.; Wiseman, J.; Skudlarek, Liotta, D.; Jason, W. Recent patents regarding the discovery of small molecule CXCR4 antagonists. Expert Opin. Ther. Patents 2009, 19(1), 23-28.
  64. Ali, S.; Heathcote, D.; Kroll, S.; Jogalekar, A.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.; Periyasamy, M.; Tolhurst, R.; Kanneganti, S.; Snyder, J.; Liotta, D.; Aboagye, E.; Barrett, A.; Coombes, R. The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity. Cancer Res. 2009, 69(15), 6208-6215.
  65. Mosley, C.; Myers, S.; Murray, E.; Santangelo, R.; Tahirovix, Y.; Kurtkaya, N.; Mullasseril, P.; Yuan, H.; Lyuboslavsky, P.; Le, P. Wilson, L.; Yepes, M.; Dingledine, R.; Traynelis, S.; Liotta, D. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic Med. Chem. 2009, 17(17), 6463-6480.
  66. MacNevin, C.; Atif, F.; Sayeed, I.; Stein, D.; Liotta, D. Development and Screening of Water- Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury. J. Med. Chem. 2009, 52(19), 6012-6023.
  67. Kasinski, A.; Du, Y.; Thomas, S.; Zhao, J.; Sun, S.; Khuri, F.; Wang, C.; Shoji M., Sun, A.; Snyder, J.; Liotta, D.; Fu, H. Inhibition of IKB Kinase-Nuclear Factor-KB Signaling Pathway by 3,5-Bis-(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin. Mol. Pharmacol. 2009, 74 (3), 654-661.
  68. Thomas, S.; Zhong, D.; Zhou, W.; Malik, S.; Liotta, D.; Snyder, J.; Hamel, E.; Giannakakou,
  69. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF- 1. Cell Cycle 2008, 7:1, 2409-2417.
  70. Thepchatri, P.; Min, J.; Ganesh, T.; Du, Y.; Lewis, I.; Kurtkaya, S.; Prussia, A.; Li, L.; Plemper, R.; Fu, H.; Liotta, D.; Snyder, J.; Dingledine, R. Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining. Curr. Med. Chem. 2009, 9 (13), 1159-1171.
  71. Pruett, ; Bushnev, A.; Hagedorn, K.; Adiga, M.; Haynes, C.; Sullards, M.; Liotta, D.; Merrill, A Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols. J. Lipid Res. 2008, 49: 1621-39.
  72. Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence activated cell sorting. Nucleic Acids Res. 2009, 1-10.
  73. Tahirovic, Y.; Geballe, M.; Gruszecka-Kowalik, E.; Myers, S.; Lyuboslavsky, P.; Le, P.; French, A.; Irier, H.; Choi, W.; Easterling, K.; Yuan, H.; Wilson, L.; McNamara, J.; Dingledine, R.; Liotta, D.; Traynelis, S.; Snyder, J. Enantiomeric propanolamines as selective N-methyl-Daspartate 2B receptor antagonists. J. Med.Chem. 2008, 51(18), 5506-5521
  74. Shoji, M.; Sun, A.; Kisiel, W.; Lu,Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.), Journal of Drug Targeting, 2008 16:3, 185-197.
  75. MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and Their β-Amino Acid Derivatives. J. Org. Chem. 2008, 73(4), 1264-1269.
  76. Zhan, W.; Jiang, Z.; Brodie, P.; Kingston, D.; Liotta, D.; Snyder, J. Design and Synthesis of C6- C8 Bridged Epothilone A. Org. Lett. 2008, 10(8), 1565-1568.
  77. Shoji, M.; Sun, A.; Kisiel, W.; Lu, Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of Drug Targeting 2008, 16(3), 185-197.
  78. MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and their B-amino Acid Derivatives. J. Org. Chem. 2008, 73, 1264-69.
  79. Zhan, W.; Liang, Z.; Zhu, A.; Kurtkaya, S.; Shim, H.; Snyder, J.; Liotta, D. Discovery of Small Molecule CXCR4 Antagonists. J. Med. Chem. 2007, 50(23), 5655-5664.
  80. Li, Y.; Mao, S.; Hager, M.; Becnel-Davis, K.; Schinazi, R.; Liotta, D. Synthesis and Evaluation of 2′-Substituted Cyclobutyl Nucleosides and Nucleotides as Potential Anti-HIV Agents. Biooorg. Med. Chem. Lett. 2007,17(12), 3398-3401.
  81. Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols. Org. Lett. 2007, 9(15), 2959.
  82. Mosley, C.; Liotta, D.; Snyder, J.; Aggarwal, B.; Surh, B.; Shishoda, Y.; Eds, S. Highly Active Anti-Cancer Curcumin Analogs. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease 2007, Vol. 595, pp. 77-103.
  83. Herold-Dublin, M.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolates of N-Acyl Thiazolidinethione to Activated Imines: A Novel Synthesis of β-Lactams. Can. J. Chem. 2006, 84(12), 1696-1699.
  84. Sun, A.; Prussia, A.; Zhan, W.; Murray, E.; Doyle, J.; Cheng, L.; Yoon, J.; Radchenko, E.; Palyulin, V.; Compans, R.; Liotta, D.; Plemper, R.; Snyder, J. Nonpeptide Inhibitors of Measles Virus Entry. J. Med. Chem. 2006, 49(17), 5080-5092.
  85. Sun, A.; Shoji, M.; Lu, Y.; Yang, J.; Liotta, D.; Snyder, J. Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. J. Med. Chem. 2006, 49(11), 3153-8.
  86. Dougherty, A.; McDonald, F.; Liotta, D.; Moody, S.; Pallas, D.; Pack, C.; Merrill, A. Synthesis of 1-Deoxysphingsine Derivatives with Conformationally Restricted Pyrrolidinediol Head Groups. Org. Lett. 2006, 8(4), 649-52.
  87. Doyle, J.; Prussia, A.; White, L.; Liotta, D.; Snyder, J.; Compans, R.; Plemper, R. Two Domains that Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein. J. Virol. 2006, 80(3), 1524-36.
  88. Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as New Anticancer Principles: An Efficient Procedure for Stereoselective Syntheses of 2-Amino-3,5-diols. Org. Lett. 2005, 7(15), 3155-3157.
  89. Plemper, R.; Doyle, J.; Sun, A.; Prussia, A.; Cheng, L.; Rota, P.; Liotta, D.; Snyder, J.; Compans, R. Design of a Small Molecule Entry Inhibitor with Activity Against Primary Measles Virus Strains. Antimicrob. Agents Chemother. 2005, 49, 3755-3761.
  90. Adams, B.; Cai, J.; Armstrong, J.; Herold, M.; Lu, Y.; Sun, A.; Snyder, J.; Liotta, D.; Jones, D.; Shoji, M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-Cancer Drugs 2005, 16(3), 263-275.
  91. Hernandez-Santiago, B.; Chen, H.; Asif, G.; Mao, S.; Beltran, T.; Hurwitz, S.; Grier, J.; McClure, H.; Chu, C.; Liotta, D.; Schinazi, R. Pharmacology and Pharmacokinetics of the Antiviral Agent ß-D-2′,3′-Dideoxy-3′-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys. Antimicrob. Agents Chemother. 2005, 49 (7), 2589-2597.
  92. Adams, B.; Ferstl, E.; Davis, M.; Herold, M.; Kurtkaya, S.; Camalier, R.; Hollingshead, M.; Kaur, G.; Sausville, E.; Rickles, F.; Snyder, J.; Liotta, D.; Shoji, M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg. Med. Chem. 2004, 12(14), 3871-3883.
  93. Ambhaikar, N.; Liotta, D.; Herold, M. A Uniquely Accessible Route to the Diastereoselective Synthesis of Azetine Derivatives, Heterocycles, 2004, 62, 217-222.
  94. Plemper, R.; Erlandson, K.; Lakdawala, A.; Sun, A.; Prussia, A.; Boonsombat, J.; Aki-Sener, E.; Yalcin, I.; Yildiz, I.; Temiz-Arpaci, O.; Tekiner, B.; Liotta, D.; Snyder, J.; Compans, J. A Target Site for Template-base Design of Measles Virus Entry Inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5628-5633.
  95. Painter, G.; Almond, M.; Mao, S.; Liotta, D. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Curr. Med. Chem. 2004, 4(10), 1035-1044.
  96. Mao, S.; Bouygues, M.; Welch, C.; Biba, M.; Chilenski, J.; Schinazi, R.; Liotta, D. The Synthesis and Anti-HIV Activity of Enantiomerically Pure D-FDOC. Bioorg. Med. Chem. Lett. 2004, 14, 4991-4994.
  97. Menaldino, D.; Bushnev, A.; Sun, A.; Liotta, D.; Symolon, H.; Desai, K.; Dillehay, D.; Peng, Q.; Wang, E.; Allegood, J.; Trotman-Pruett, S.; Sullards, M.; Merrill, A. Sphingoid bases and de novo ceramide synthesis: Enzymes involed, pharmacology and mechinisma of activation/regulation, Pharm. Res. 2003, 47 (5), 373-381.
  98. Guindon, Y.; Ogilvie, W.;Bordeleau, J.; Cui, W.; Durkin, K.; Gorys, V.; Juteau, H.; Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. Opening of Tartrate Acetals Using Dialkylboron Bromide. Evidence for Stereoselectivity Downstream from Ring Fission, J. Amer. Chem. Soc. 2003,125(2), 428-436.
  99. Painter,G.; Rimsky, L.; Furman, P.; Liotta, D.; Schinazi, R.; Quinn, J. Preclinical and Clinical Development of the anti-HIV, anti-HBV Oxathiolane Nucleoside Analog Emtricitabine. Front. Vir. Hep.2003, 451-484.
  100. Ambhaikar, N.; Snyder, J.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolate of N-Acyl Thiazolidinethione to O-Methyl Oximes: A Novel, Stereoselective Synthesis of α,β- Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation. J. Am. Chem. Soc. 2003, 125 (3), 3690-3691.
  101. Merrill, A., Sullards, M.; Allegood, J.; Wang, E.; Linn, S.; Andras, L.; Liotta, D.; Hartl, M.; Humpf,
  102. Insights into the modulation of ceramide metabolism by naturally occurring and synthetic sphingolipid analogs as monitored by electrospray tandem mass spectrometry, “Ceramide Signaling” (A. H.Futerman, ed., Landes Bioscience Pub.), ISBN: 0-306-47442-5, 2002.
  103. Lakdawala, A.; Morgan, D.; Liotta, D.; Lynn, D.; Snyder, J. Dynamics and Fluidity of Amyloid: A Model of Fibrous Protein Aggregates, J. Am. Chem. Soc. 2002, 124 (51),15150-15151.
  104. Morgan, D.; Lynn, D.; Lakdawala, A.; Liotta, D.; Snyder, J. Amyloid structure: models and theoretical considerations in fibrous aggregates. J. Chin. Chem. Soc. (Taipei, Taiwan) 2002, 49 (4), 459-466.
  105. Ferstl, E.; Venkatesan, H.; Ambhaikar, N.; Snyder, J.; Liotta, D. Thiazolidine-2-thione directed diastereoselective addition of chlorotitanium enolates to aldimines. Synthesis 2002, (14), 2075- 2083.
  106. Painter, G.; Anderson, K.; Bouygues, M.; Joubert, M.; Liotta, D.Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV. Curr. Med. Chem.: Anti-Infective Agents 2002, 1 (2), 99-117.
  107. Schinazi, R.; Mellors, J.; Bazmil, H.; Diamond, S.; Garber, S.; Gallagher, K.; Geleziunas, R.; Klabe, R.; Pierce, M.; Rayner, M.; Wu, J.; Zhang, H.; Hammond, J.; Bacheler, L.; Manion, D.; Otto, M.; Stuyver, L.; Trainor, G.; Liotta, D.; Erikson-Viitanen, S. DPC 817: a Cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants. Antimicrob. Agents Chemother. 2002, 46 (5), 1394-1401.
  108. Desai, K.; Sullards, M.; Allegood, J.; Schmelz, E.; Hartl, M.; Humpf, H.; Liotta, D.; Peng, Q.; Merrill, A. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis(Apoptosis induced by sphingoid bases). Biochem. Biophys. Acta special issue 2002, 1585 (2-3), 188-192.
  109. Nicolaou, K.; Namato, K.; Ritzen, A.; Ulven, T.; Shoji, M.; Li, J.; D’Amico, G.; Liotta, D.; Altmann, K.; Giannakakou, P. Chemical Synthesis and Biological Evaluation of cis- and trans- 12, 13-Cyclopropyl and 12,13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues. J. Am. Chem. Soc. 2001, 123(38), 9313-9323.
  110. Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Shi, J.; Liotta, D.; Coderre, J.; Olson,
  111. Preclinical Development of β-D-5-o-Carboranyl-2’-Deoxyuridine (D-CDU) for the Treatment of Malignant Brain Tumors. Frontiers in Neutron Capture Therapy (Hawthorne et al.,Ed.) 2001, 2, 1121-1124.
  112. Lakdawala, A.; Wang, M.; Nevins, N.; Liotta, D.; Roszak, D.; Lozynski, M.; Snyder,
  113. Calculated Conformer Energies for Organic Molecules with Multiple Polar Functionalities are Method Dependent: Taxol (Case Study). BMC Chemical Biology 2001, 1:2 .
  114. Hill, C.; Judd, D.; Nettles,J.; Nevins, N.; Schinazi, R.; Snyder, J.; Liotta, D.; Tang,
  115. Polyoxometalate HIV-1 Protease Inhibitors. Modeling Polyoxometalate-Enzyme Interactions. J. Am. Chem. Soc. 2001, 123, 886-897.
  116. Venkatesan, H.; Davis, M.; Snyder, J.; Liotta, D. Total Synthesis of SR 121463 A, a Highly Potent and Selective Vasopressin V2 Receptor Antagonist. J. Org. Chem. 2001, 66, (11), 3653- 3661.
  117. Wang, M.; Cornett,B.; Nettles, J.; Liotta, D.; Snyder, J. The Oxetane Ring in Taxol. J. Org. Chem. 2000, 65, 1059-1068.
  118. Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Tharnish, P.; Shi, J.; Liotta, D.; Coderre, J.; Olson, J. Treatment of Isografted 9L Rat Brain Tumors with β-5-ο-Carboranyl-2’- Deoxyuridinr Neutron Capture Therapy. Clin. Cancer Res. 2000, 6, 725-730.
  119. Curfman, C.; Liotta, D. Synthesis of Sphingosine and Sphingoid Bases. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling, 2000, 311, 391-440. (Merrill, A.; Hannun, Y. Eds.).
  120. Bushnev, A.; Liotta, D. Practical Synthesis of N-palmitoylsphingomyelin and N- palmitoyldihydrosphingomyelin. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling (A. H. Merrill and Y. A. Hannun, Eds.), 2000, 311, 535-546.
  121. Wang, M.; Xia, D.; Schestopol, M.; Kim, Y.; Hwang, D.; Jansen, J.; Botta, M.; Liotta, D.; Snyder,
  122. A Unified and Quantitative Receptor Model for the Microtubule Binding of Taxol and Epothilone. Org. Lett. 1999, 1, 43-46.
  123. Schmelz, E.; Bushnev, A.; Dillehay, D.; Sullards, M.; Liotta, D.; Merrill, A. Ceramide β-D- glucuronide: Synthesis, digestion and suppression of early biomarkers of colon carcinogenesis. Cancer Res. 1999, 59, 5768-5772.
  124. Warden, L.; Menaldino, D.; Wilson, T.; Liotta, D.; Smith, E.; Merrill, A. Identification of ammonium ion and 2,6-bis-(ω-aminobutyl)-3,5-diimino-piperazine as endogenous factors that account for the burst of sphingosine upon changing the medium of J774 cells in culture. J. Biol. Chem. 1999, 48, 33875-33880.
  125. Ma, L.; Hurwutz, S.; Shi, J.; McAtee, J.; Liotta, D.; McClure, H.; Schinazi, R. Pharmacokinetics of the Antiviral Agent ß-D-2’,3’-Didehydro-2’,-3’-Dideoxy-5-Fluorocytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1999, 43(2), 381-384.
  126. Shi, J.; McAtee, J.; Schlueter-Wirtz, S.; Tharnish, P.; Juodawlkis, A.; Liotta, D.; Schinazi,
  127. Synthesis and Biological Evaluation of 2’,3’-Didehydro-2’,3’-dideoxy-5-fluorocytidine (D4FC) Analogs: Discovery of Carbocyclic Nucleoside Triphosphates with Potent Inhibitory Activity Against HIV-1 Reverse Transcriptase. J. Med. Chem. 1999, 42, 859-867.
  128. Schinazi, R.; McAtee, J.; Liotta, D. A Completely Diastereoselective Electrophilic Fluorination of a Chiral, Non-carbohydrate Sugar Ring Precursor: Application to the Synthesis of Several Novel 2’-Fluoro Nucleosides. J. Org. Chem. 1998, 63, 2161-2167.
  129. Birt, D.; Merrill, A.; Barnett, T.; Enkvetchakul, B.; Pour, P.; Liotta, D.; Geisler, V.; Menaldino, D.; Schwartzbauer, J. Inhibition of Skin Carcinomas but not Papillomas by Sphingosine, N- methylsphingosine, and N-acetyl Sphingosine. Nutr & Cancer, 1998, 31, 119-126.
  130. Humpf, ; Schmelz, E.; Meredith, F.; Vesper, H.; Vales, T.; Menaldino, D.; Liotta, D.; Merrill, Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase: Formationof N-Palmitoyl-aminopentol (PAP1) Produces a Toxic Metabolite of Hydrolyzed Fumonisin (AP1). J. Biol. Chem. 1998, 30, 19060-19064.
  131. Snyder, J.; Xia, X.; Schestopol, M.; Kim, Y.; Bray, D.; Cain, M.; Liotta, D.; Koehler, K.; Jansen, Minireceptors for Molecular Design, in “Rational Molecular Design in Drug Research,” (T. Liljefors, F.S.Jorgenson, and P. Krogsgaard-Larsen, Eds., Munksgaard, Copenhagen). 1998, 115-135.
  132. Schinzai, R.; McMillan, A.; Lloyd, R.; Schuleter-Wirtz, S.; Liotta, D.; Chu, C. Molecular Properties of HIV-1 Resistant to (+) and (–)-Enantiomers and Racemates of Oxathlolane Cytosine Nucleosides and their Potential for the Treatment of HIV and HBV Infections. Antiviral Res. 1997, 34 (2).
  133. Nikolova-Karakashian, M.; Morgan, E.; Alexander, C.; Liotta, D.; Merrill, A. Bimodal Regulation of Ceramidase by Interleukin-1b: Implications for the Regulation of Cytochrome P450 2C11 (CYP2C11). J. Biol. Chem. 1997, 272, 18718-18724.
  134. X. Xia, J. Wang, M. W. Hager, N. Sisti and D. Liotta. Stereocontrolled Synthesis of β-2’- Deoxypyrimidime Nucleosides via Intramolecular Glycosylations. Tetrahedron Lett. 1997, 38, 1111-1112.
  135. Schmelz, E.; Bushnev, A.; Dillehay, D.; Liotta, D.; Merrill, A. Suppression of Aberrant Colonic Crypt Foci by Synthetic Sphingomyelina with Either Saturated of Unsaturated Sphingoid Base Backbones. Nutr. & Cancer 1997, 28, 81-85.
  136. Kikolova-Karakashian, M.; Vales, T.; Wang, E.; Menaldino, D.; Alexander, C.; Goh, J.; Merrill, A.; Liotta, D. Ceramide Synthase and Ceramidases in the Regulation of Sphingolipid Base Metabolism. Sphingolipidmediated Signal Transduction. Molecular Biology Intelligence Unit, (Hannun Y. A., Ed.) 1997, 159-172.
  137. Goudgaon, N.; El-Kattan, Y.; Xia, X.; McAtee, J.; Soria, J.; Wey, S.; Liotta, D.; Schinazi, R. A General Synthetic Method of 5-Carboranyluracil Nucleosides with Potential Antiviral Activity and Use in Neutron Capture Therapy, Nucleosides and Nucleotides 1997, 16, 2133-2150.
  138. Merrill, A.; Liotta, D.; Riley, R. Fumonisins: Fungal Toxins that Shed Light on Sphingolipid Function. Trends Cell Biol. 1996, 6, 218.
  139. Alexander, C.; Liotta, D. A Diastereoselective Synthesis of (2S, 3R, 4S)-Amino-1-cyclohexyl-6- methylheptane-3,4-diol, the Abbott Aminodiol. Tetrahedron Lett. 1996, 12, 1961.
  140. Captain, L.; Xia; Xiaoyang; Liotta, D. Remote Asymmetric Induction in Organocopper Conjugate Additions to 3-Ketoacrylates. Tetrahedron Lett. 1996, 37 (25), 4293.
  141. Merrill, A.; Liotta, D.; Riley, R. Bioactive Properties of Sphingosine and Structurally Related Compounds. Handbook of Lipid Research, Lipid Second Messengers 1996, 8, 205.
  142. Merrill, A.; Liotta, D.; Riley, R. Sphingolipid Analog Biomodulators in Foods Alter Sphingolipid Metabolism. Implications for Health and Disease. Proc. Nutri. Soc. Australia, 1996, 20, 124.
  143. Merrill, Jr., A.; Liotta, D.; Riley, R. Sphingolipids as Regulators of Cellular Growth, Differentiation, and Behavior. Adv. Lipobiology, 1996, 1, 273.
  144. Merrill, A.; Wang, E.; Vales, T.; Smith, E.; Schroeder, J.; Menaldino, D.; Alexander, C.; Crane, H.; Xia, J.; Liotta, D.; Meredith, R.; Riley, R. Fumonisin Toxicity and Sphingolipid Biosynthesis. Proceedings of the ACS Symposium on Fumonisins in Food (April 2-7, 1995, Anaheim, CA), Adv. Exp. Med. Biol. 1996, 392, 297.
  145. Liotta, D.; Jones, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. Adv. Mol. Modeling 1995, 3, 1-19.
  146. Wilson, L.; Hager, M.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleosides Bases with Furanoside Sugars. Synthesis, 1995, 1465.
  147. Jones, D.; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Adv. Mol. Modeling 1995, 3, 67-98.
  148. Choi, W.; Churchill, H.; Lynch, J.; Volante, R.; Reider, P.; Shinkai, I.; Jones, D.; Liotta, D. An Unusual Stereoselective Decarboxylation: A Key Reaction in the Synthesis of an Important Intermediate for Carbapenem Antibiotics. J. Org. Chem. 1995, 60, 8367.
  149. Xie, H.; Voronkov, M.; Liotta, D.; Korba, B.; Schinazi, R.; Richman, D.; Hostetler, Phosphatidyl-2′,3′-Thiacytidine: Synthesis and Antiviral Activity, in Hepatitis B and HIV-1 Infected Cells. Antiviral Res. 1995, 28, 113.
  150. Wilson, L.; Hager, M.; El-Kattan, Y.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases With Furanoside Sugars. Synthesis 1995, 12, 1465- 79.
  151. Hoekstra, W.; Bonner, M.; Andrade-Gordon, P.; Evangelisto, M.; Keane, P.; Press, J.; Tomko, K.; Fan, F.; Kloczewiak, M.; Mayo, K.; Durkin, K.; Liotta, D. Design and Evaluation of Non- peptide Fibrinogen Gamma Chain Based GPIIB/IIIA Antagonists. J. Med.Chem. 1995, 38, 1582.
  152. Chao, R.; Bielawska, A.; Pushkareva, M.; Crane, H.; Lagu, B.; Merrill, A.; Liotta, D.; Hannun,
  153. Stereoselectivity of Induction of Rb Dephsophorylation by D-erythro-sphingosine Implicated Rb in Growth Suppression by Sphingosine. Biochem. 1995, 34, 1885.
  154. V.Dirsch, J. Frederico, N. Zhao, G. Cai, Y. Chen, S. Vunnam, J. Odingo, H. Pu, K. Nakanishi,
  155. Berova, D. Liotta, A. Bielawska and Y. Hannun. A Two-Step Chemical and Circular Dichroic Method for Assigning the Absolute Configurations of Sphingosines. Tetrahedron Lett. 1995, 36, 4959.
  156. Schroeder, J.; Crane, H.; Xia, J.; Merrill, A.; Liotta, D. Disruption of Sphingolipid Metabolism and Stimulation of DNA Synthesis by Fumonisin B1. A Molecular Mechanism for Carcinogenes Associated with Fursarium moniliforme. J. Biol. Chem., 1994, 269, 3475.
  157. Lagu, B.; Liotta, D. Diastereoselective Synthesis of the Key Lactone Intermediate for the Preparation of Hydroxyethylene Dipeptide Isosteres. Tetrahedron Lett. 1994, 35(4), 547-50.
  158. Goh, J.; Lagu, B.; Wurster, J.; Liotta, D. Aldol Reactions of a-(N,N-Dibenzylamino) Ethyl Ketones. Tetrahedron Lett. 1994, 35(33), 6029-32.
  159. Jones, D.; Liotta, D.; Choi, W.; Volante, R.; Reider, P.; Shinkai, I.; Churchill, H.; Lynch, J. A Facially-Selective Protonation Controls the Stereochemistry of a Key Intermediate in the Synthesis of 1b-Methylcarbapenems. J. Org. Chem. 1994, 59(14), 3749-51.
  160. Jarugula, V.; Schinazi, R.; Fulcrand, G.; El Kattan, Y.; Boudinot, F.; Liotta, D. Pharmacokinetics of 5-Carboranyl-2’-Deoxyuridine in Rats. J. Pharm. Sci. 1994, 83(12), 1697-9.
  161. Schinazi, R.; Gosselin, G.; Faraj, A.; Korba, B.; Liotta, D.; Chu, C.; Mathe, C.; Imbach, J.; Sommadossi, J. Pure Nucleoside Enantiomers of b-2′,3′-Dideoxycytidine Analogues are Selective Inhibitors of Hepatitis B Virus and Human Immunodeficiency Virus in Vitro. Antimicrob. Agents Chemother. 1994, 38(9), 2172-4.
  162. Hoekstra, W.; Press, J.; Bonner, M.; Andrade-Gordon, P.; Keane, P.; Durkin, K.; Liotta, D.; Mayo, K. Adamantane and Nipecotic Acid Derivatives as Novel b-Turn Mimics. Bio. Med. Chem. Lett. 1994, 4(11), 1361-4.
  163. Schinazi, R.; Goudgaon, N.; Fulcrand, G.; El-Kattan, Y.; Lesnikowski, Z.; Moravek, J.; Liotta,
  164. Cellular Pharmacology and Biological Activity of 5-Carboranyl-2’-Deoxyuridine. Intl. J. Radiation Oncol. Int. J. Radiation Oncology Biol. Phys. 1994, 28(5), 1113-20.
  165. Abobo, C.; Ni, L.; Schinazi, R.; Liotta, D.; Boudinot, F. Pharmacokinetics of 2′,3′-Dideoxy-5- fluoro-3′-thiacytidine in Rats. J. Pharm. Sci. 1994, 83(1), 96-9.
  166. Guindon, Y.; Yoakim, C.; Gorys, V.; Ogilvie, W.; Delorme, D.; Renaud, J.; Robinson, G.; Lavallee, J.; Slassi, A.; Jung, G.; Rancourt, J.; Durkin, K.; Liotta, D. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin. J. Org. Chem. 1994, 59(5), 1166-78.
  167. Lagu, B.; Liotta, D. Surprisingly High Diastereoselection in the Aldol Reactions of Sodium Enolates of a-Amino Methyl Ketones. Tetrahedron Lett. 1994, 35(26), 4485-8.
  168. El-Kattan, Y.; Goudgaon, N.; Fulcrand, G.; Liotta, D.; Schinazi, R. Synthesis of 5- Carboranyluracil and its Glycosylation with Normal and Modified Carbohydrates. Current Topics in the Chemistry of Boron (Royal Society of Chemistry), 1994, 181-4.
  169. Bielawska, A.; Crane, H.; Liotta, D.; Obied, L.; Hannun, Y. Selectivity of Ceramide-Mediated Biology: Lack of Activity of Erthro-dihydroceramide. J. Biol. Chem. 1993, 268(35), 26226-32.
  170. M. Y. Pushkareva, A. Bielawska, D. Menaldino and Y. Hannun. Regulation of Sphingosine- Activated Protein Kinases: Specificity of Activation by Sphingoid Bases and Inhibition by Free Fatty Acids. Biochem. J. 1993, 294 (pt3), 699-703.
  171. Sperka, J.; Liotta, D. Onium Ions Are Not On The Reaction Coordinate In The Formation Of Heterocycles Via Electrophileinduced Alkenol Cyclizations. Heterocycles, 1993, 35(2), 701-6.
  172. Mathez, D.; Schinazi, R.; Liotta, D.; Leibowitch, J. Infectious Amplification of Wild Type Human Immunodeficiency Virus from Patients’ Lymphocytes and their Modulation by Reverse Transcriptase Inhibitors In Vitro. Antimicrob. Agents Chemother. 1993, 37(10), 2206-11.
  173. Wang, J.; Wurster, J.; Wilson, L.; Liotta, D. Stereocontrolled Glycosylations Via Additions of Sulfur Electrophiles to Glycals. Tetrahedron Lett. 1993, 34(31), 4881-4.
  174. Jones, D; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Tetrahedron Lett. 1993, 34(45), 7209-12.
  175. Lagu, B.; Crane, H.; Liotta, D. Highly Diastereoselective Aldol Reactions of Chiral Methyl Ketones. J. Org. Chem. 1993, 58(16), 4191-3.
  176. Wilson, J.; Martin, J.; Borrota-Esoda, K.; Hopkins, S.; Painter, G.; Furman, P. The 5′- Triphosphates of the (-)- and (+)-Enantiomers of Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3- Oxathioan-5-yl]Cytosine Equally Inhibit Human Immunodeficiency Virus Type-1 Reverse Transcriptase. Antimicrob. Agents Chemother. 1993, 37(8), 1720-2.
  177. Schinazi, R.; Lloyd, R.; Nguyen, M.; Cannon, D.; Ilksoy, N.; Chu, C.; Liotta, D.; Bazmi, H.; Mellors, J. Characterization of Human Immunodeficiency Viruses Resistant to Oxathiolane- Cytosine Nucleosides. Antimicrob. Agents Chemother. 1993, 37(4), 875-81.
  178. Schinazi, R.; Goudgaon, N.; Soria, J.; Liotta, D. Synthesis, Antiviral Activity, Cytotoxicity and Cellular Pharmacology of 5-Carboranyl-Pyrimidine Nucleosides. Advances in Neutron Capture Therapy, 1993, 285-8.
  179. Van Roey, P.; Pangborn, W.; Schinazi, R.; Painter, G.; Liotta, D. Absolute Configuration of the Antiviral Agent (-)-Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioan-5-yl]Cytosine. Antiviral Chem. Chemother. 1993, 4(6), 369-75.
  180. Shewach, D.; Liotta, D.; Schinazi, R. Affinity of the Antiviral Enantiomers of Oxathioane Cytosine Nucleosides for Human 2′-Deoxycytidine Kinase. Biochem. Pharmacol. 1993, 45(7), 1540-3.
  181. Frick, L.; Furman, P.; Liotta, D.; Painter, G.; Firfine, E.; Nelson, D. Pharmacokinetics, Oral Bioavailability and Metabolic Disposition in Rats of 2′-Deoxy-3′-thia-5-fluorocytidine, a Nucleoside Analog Active Against HIV and HBV. Antimicrob. Agents Chemother. 1993, 37(11), 2285-92.
  182. Wilson, L.; Choi, W.; Spurling, T.; Liotta, D.; Schinazi, R.; Cannon, D.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis and Anti-HIV Activity of Pyrimidine Dioxanyl Nucleoside Analogues. Bioorg. Med. Chem. Lett. 1993, 3(2), 169-74.
  183. Choi, W.; Yeola, S.; Liotta, D.; Schinazi, R.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis, Anti-HIV and Anti-HBV Activity of Pyrimidine Oxathiolane Nucleoside Analogues. Bioorg. Med. Chem. Lett. 1993, 3(4), 693-6.
  184. Jones, D.; Liotta, D.; Shinkai, I.; Mathre, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. J. Org. Chem. 1993, 58(4), 799-801.
  185. Hager, M.; Liotta, D. An Efficient Synthesis of 3′-Fluoro-3′-deoxythymidine (FLT). Tetrahedron Lett. 1992, 33(47), 7083-6.
  186. Wurster, J.; Wilson, L.; Morin, G.; Liotta, D. Suppression of Racemization During the Diastereoselective C-3 Functionalization of 5-Hydroxymethyl-2-(5H)-furanones. Tetrahedron Lett. 1992, 33(39), 5689-92.
  187. Chang, C.; Doong, S.; Zhou, J.; Beach, J.; Jeong, L.; Chu, C.; Liotta, D.; Schinazi, R.; Chang,
  188. Deoxycytidine deaminase-resistant Stereoisomer is the Active Form of (-)-2′,3′-dideoxy-3′- thiacytidine in the Inhibition of Hepatitus B Replication. J. Biol. Chem. 1992, 267(20), 13938-42.
  189. Schinazi, R.; McMillan, A.; Cannon, D.; Mathis, R.; Lloyd, R.; Peck, A.; Sommadossi, J.; St. Clair, M.; Wilson, L.; Furman, P.; Choi, W.; Liotta, D. Selective Inhibition of Human Immunodeficiency Viruses by Racemates and Enantiomers of (Cis-5-fluoro-1-{2- hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine. Antimicrob. Agents Chemother. 1992, 36(11), 2423-31.
  190. Furman, P.; Davis, M.; Liotta, D.; Paff, M.; Frick, L.; Nelson, D.; Dornsife, R.; Wurster, J.; Wilson, L.; Tuttle, J.; Condrey, L.; Averett, D.; Schinazi, R.; Painter, G. The Anti-Hepatitis B Virus Activity, Cytotoxicity and Anabolic Profile of the (-) and (+) Enantiomers of Cis-5-fluoro-1-{2-hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine (FTC). Antimicrob. Agents Chemother. 1992, 36 (12), 2686-92.
  191. Schinazi, R.; Boudinot, F.; Ibrahim, S.; Manning, C.; McClure, H.; Liotta, D. Pharmacokinetics and Metabolism of Racemic 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1992, 36(11), 2432-8.
  192. Hoong, L.; Strange, L.; Liotta, D.; Koszalka, G.; Burns, C.; Schinazi, R. Enzyme-Mediated Enantioselective Preparation of Pure Enantiomers of the Antiviral Agent FTC and Related Compounds. J. Org. Chem. 1992, 57(21), 5563-5.
  193. Durkin, K.; Liotta, D.; Rancourt, J.; Lavallée, J.; Boisvert, L.; Guindon, Y. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. A Study of Transition States Using Semi-Empirical Calculations. J. Am. Chem. Soc. 1992, 114(12), 4912-14.
  194. Wilson, L.; Liotta, D. Diastereoselective Sulfenylation Reactions Employing N – Thiophenyllactams Under Non-Basic Conditions. J. Org. Chem. 1992, 57(7), 1948-50.
  195. Enkvetchakul, B.; Barnett, T.; Liotta, D.; Geisler, V.; Menaldino, D.; Merrill, A.; Birt,
  196. Influences of Sphingosine on Two-Stage Skin Tumorigenesis IN SENCAR Mice. Cancer Lett. 1992, 62(1), 35-42.
  197. Schinazi, R.; Chu, C.; Peck, A.; McMillan, A.; Mathis, A.; Cannon, D.; Jeong, L.; Beach, J.; Choi, W.; Yeola, S.; Liotta, D. Activity of Four Optical Isomers of 2′,3′-Dideoxy-3′-Thiacytidine (BCH-189) Aganist HIV-1 in Human Lymphocytes. Antimicrob. Agents Chemother. 1992, 36(3), 672-6.
  198. Swiss, K.; Hinkley, W.; Maryanoff, C.; Liotta, D. Complementary Facial Selectivity in Conjugate Additions to g-Hydroxyenones. Synthesis, 1992, (1-2), 127-31.
  199. Doong, S.; Tsai, C.; Schinazi, R.; Liotta, D.; Cheng, Y. Inhibition of the Replication of Hepatitis B Virus In Vitro by 2′,3′-Dideoxy-3′-thiacytidine and Related Analogues. Proc. Natl. Acad. Sci. U.S.A. 1991, 88(19), 8495-9.
  200. Choi, W.; Wilson, L.; Yeola, S.; Liotta, D.; Schinazi, R. In Situ Complexation Directs The Stereochemistry of N-Glycosylation in the Synthesis of Thialanyl and Dioxolanyl Nucleoside Analogues. J. Am. Chem. Soc. 1991, 113(24), 9377-9.
  201. Swiss, K.; Choi, W.; Liotta, D.; Maryanoff, C.; Abdel-Magid, A. Use of Magnesium Cation in Aldol Additions – A Convenient Method for Achieving Anti-Aldol Selectivity. J. Org. Chem.1991, 56(21), 5978-80.
  202. Merrill, A.; Liotta, D. Lipids as Hormones and Second Messengers. Current Opinions in Structural Biology 1991, 1(4), 516-21.
  203. Hager, M.; Liotta, D. Cyclization Protocols for Controlling the Glycosidic Stereochemistry of Nucleosides. Application to the Synthesis of the Antiviral Agent, 3′-a-Azidothymidine (AZT). J. Am. Chem. Soc. 1991, 113(13), 5117.
  204. Goldkorn, T.; Dressler, K.; Muindi, J.; Radin, N.; Mendelsohn, J.; Menaldino, D.; Liotta, D.; Kolesnick, R. Ceramide Stimulates Epidermal Growth Factor Receptor Phosphorylation in A431 Human Epidermoid Carcinoma Cells: Evidence that Ceramide Mediates Sphingosine Action. J. Biol. Chem. 1991, 266(24), 16092-7.
  205. Liotta, D.; Swiss, K. Addition Reactions with Formation of Carbon-Sulfur or Carbon Selenium Bonds. Comprehensive Organic Chemistry (B. M. Trost, I. Fleming, Ed., S. V. Ley, Vol. Ed.) Pergamon Press, 1991, 7, 515 – 526.
  206. Stevens, V.; Nimkar, S.; Jamison, W.; Liotta, D.; Merrill, A. Characteristics of the Growth Inhibition and Cytotoxicity of Long-chain (Sphingoid) Bases for Chinese Hamster Ovary Cells: Evidence for an Involvement of Protein Kinase C. Biochim. Biophys. Acta 1990, 1051(1), 37-45.
  207. Liebeskind, L.; Chidambaram, R.; Nimkar, S.; Liotta, D. A Synthesis of the Abietane Diterpenoid Quinone Royleanone via Maleoylcobalt Technology. Tetrahedron Lett. 1990, 31(26), 3723-6.
  208. Durkin, K.; Liotta, D. Solvation Controlled Diastereofacial Selectivity in Alkylations of Bicyclic Lactam Enolates. J. Am. Chem. Soc. 1990, 112(22), 8162-3.
  209. Swiss, K.; Liotta, D.; Maryanoff, C. Mechanistic Aspects of Ligand Assited Nucleophilic Addition Reactions. J. Am. Chem. Soc., 1990, 112(25), 9393-4.
  210. Durkin, K.; Sherrod, M.; Liotta, D. Empirical Derivation of Molecular Mechanics Parameter Sets: Application to b-Lactams. Advances in Molecular Modeling, 1990, JAI Press, 2, 93-133.
  211. Wilson, L.; Liotta, D. A General Method for Controlling Glycosylation Stereochemistry in the Synthesis of 2′-Deoxyribose Nucleosides. Tetrahedron Lett. 1990, 31(13), 1815-18.
  212. Swiss, K.; Choi, W.; Mohan, J.; Barnum, C.; Saindane, M.; Zima, G.; Liotta, D. Reactions Involving Selenium Metal As An Electrophile. Scope and Limitations of the Enolate-Selenolate Transformation. Heteroatom Chem. 1990, 1(2), 141-9.
  213. Greenberg, P.; Merrill, A.; Grabowski, G.; Liotta, D. Human acid b-Glucosidase: Use of Sphingosyl and N-Alkyl-Glucosylamine Inhibitors to Investigate the Properties of the Active Site. Biochim. Biophys. Acta 1990, 1039(1), 12-20.
  214. Durkin, K.; Sherrod, M.; Liotta, D. A New Model Parameter Set for β-Lactams. J. Org. Chem. 1989, 54(25), 5839-41.
  215. Slife, C.; Wang, E.; Hunter, R.; Wang, S.; Burgess, C.; Liotta, D.; Merrill, A. Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum. J. Biol. Chem. 1989, 264(18), 10371-7.
  216. Rodriguez-Paris, J.; Shoji, M.; Yeola, S.; Liotta, D.; Vogler, W.; Kuo, J. Fluorimetric Studies of Protein Kinase C Interactions with Phospholipids. Biochem. Biophys. Res.Commun. 1989, 159(2), 495-500.
  217. McCormick, M.; Monahan, R.; Soria, J.; Goldsmith, D.; Liotta, D. Effects of Substitution on Intramolecular Alkoxypalladation Carbonylation Reactions. J. Org. Chem. 1989, 54(19), 4485-7.
  218. Merrill Jr., A.; Nimkar, S.; Menaldino, D.; Hannun, Y.; Loomis, C.; Bell, R.; Tyagi, S.; Lambeth, J.; Stevens, V.; Hunter, R.; Liotta, D. Structural Requirements for Long-Chain (Sphingoid) Bases as Inhibitors of Protein Kinase C in vitro and Cellular Effects of These Compounds. Biochemistry 1989, 28(8), 3138-45.
  219. Wilson, E.; Wang, E.; Mullins, R.; Uhlinger, D.; Liotta, D.; Lambeth, J.; Merrill, A. Modulation of the Free Sphingosine Levels in Human Neutrophils by Phorbol Esters and Other Factors. J. Biol. Chem. 1988, 263(19), 9304-9.
  220. Hoekstra, W.; Zima, G.; Solomon, M.; Liotta, D. The Case Favoring Direct C-Alkylation of Heteroatom-Substituted Enolates. J. Org. Chem. 1988, 53(21), 5058-62.
  221. Solomon, M.; Jamison, W.; McCormick, M.; Liotta, D.; Cherry, D.; Mills, J.; Shah, R.; Rogers, J.; Maryanoff, C.; Paragamian, V. Ligand Assisted Nucleophilic Additions. Control of Site and Face Attack of Nucleophiles on 4-Oxido Enones. J. Am. Chem. Soc. 1988, 110(11), 3702-4.
  222. Nimkar, S.; Menaldino, D.; Jamison, W.; Merrill, A.; Liotta, D. A Stereoselective Synthesis of Sphingosine, A Protein Kinase C Inhibitor. Tetrahedron Lett. 1988, 29(25), 3037-40.
  223. Dunams, T.; Hoekstra, W.; Pentaleri, M.; Liotta, D. Molecular Aggregation and Its Applicability to Synthesis. The Diels-Alder Reaction. Tetrahedron Lett. 1988, 29(31), 3745-8.
  224. Liotta, D.; Saindane, M.; Waykole, L.; Grossman, J.; Stephens, J. Trajectories of Proton Transfer Reactions. Experimental Determination of the Magnitude of Primary Deuterium Isotope Effects for Proton-transfers Occurring at Acute Angles. J. Am. Chem. Soc. 1988, 110(8), 2667-8.
  225. Merrill, A.; Wang, E.; Mullins, R.; Jamison, W.; Nimkar, S.; Liotta, D. Quantitation of Free Sphingosine in Liver by High-Performance Liquid Chromatography. Anal. Biochem. 1988, 171(2), 373-81.
  226. Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction In A Flourocarbon Medium. II. Kinetics of the 1,2,3,4-Tetrahydroquinoline Reaction. Fuel 1987, 66, 1621.
  227. Liotta, D.; Brown, D.; Hoekstra, W.; Monahan, R. Pyridinium Dichromate-Induced 1,3-Oxidative Rearrangements of Enynols. Tetrahedron Lett. 1987, 28 (10), 1069-72.
  228. Maryanoff, B.; Nortey, S.; Inners, R.; Campbell, S.; A. B. Reitz and D.C. Liotta. Synthesis of C- Arabinofuranosides. Phosphonate and Carboxylate Isosteres of b-D-Arabinose-1,5- Diphosphate. Carbohydr. Res. 1987, 171, 259-78.
  229. Reitz, A.; Nortey, S.; Maryanoff, B.; Liotta, D.; Monahan, R. Stereoselectivity of Electrophile- Promoted Cyclizations of g-Hydroxyalkenes. An Investigation of Carbohydrate-Derived and Model Substrates. J. Org. Chem. 1987, 52(19), 4191-4204.
  230. Liotta, D.; Ott, W. Triene Cyclizations. Total Synthesis of Pallescensin A. Synth. Commun., 1987, 17(14), 1655-65.
  231. Nucleophilic Selenium in “Organoselenium Chemistry” (Wiley-Interscience), D. Liotta, Ed., 1987, 207-242. Liotta, D.; Monahan, R.; Waykole, L.; Brown, D.
  232. Liotta, D.; Saindane, M.; Monahan, R.; Brothers, D.; Fivush, A. Rearrangement of α- Phenylselenenyl Ketones. Synth. Commun. 1986, 16 (12), 1461-8.
  233. Liotta, D.; Saindane, M.; Brothers, D. Based-Induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47 (8), 1598-600.
  234. Liotta, D.; Monahan, R. Selenium in Organic Synthesis. Science 1986, 231 (4736), 356-61.
  235. Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction in a Fluorocarbon. 1. Nitrogen Compounds as Hydrogen Transfer Agents. Fuel 1986, 65 (1), 148-50.
  236. Fraser-Reid, B.; Grossman, J.; Underwood, R.; Osterhout, M.; Liotta, D. Some Observations on the Relative Reactivities of a-Enones of Oxanes and Cyclohexanes. J. Org. Chem. 1986, 51(11), 2152-5.
  237. Liotta, D; Saindane, M.; Barnum, C.; Zima, G. Synthetic Applications of 2- Phenylselenenylenones. 3. An Overview. Tetrahedron 1985, 41(21), 4881-9.
  238. Goldsmith, D.; Liotta, D.; Waykole, L.; Hoekstra, W.; Volmer, M. Preparation and Reactivity of α-phenylselenyl Ethers. Tetrahedron 1985, 41 (21), 4873-80.
  239. Gupton, J.; DeCrexcenzo, G.; Colon, C.; Baran, D.; Dukesherer, D.; Novick, S.; Liotta, D.; Idoux, P. Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides. Can. J. Chem. 1985, 63 (11), 3037-42.
  240. Bresciani-Pahor, N.; Calligaris, M.; Randaccio, L.; Marzilli, L.; Summers, M.; Toscano, P.; Grossman, J.; Liotta, D. The 2,2,2-Trifluoroethyl Ligand: A Structural “Reporter” Group for Carbanion Character of Alkyl Ligands in Organometallic Compounds. Organometallics 1985, 4(4), 630-6.
  241. Liotta, D.; Saindane, M.; Sunay, U.; Jamison, W.; Phillips, P.; Grossman, J. Acetylide Additions to Enediones. Regioselectivity Based on Stereoelectronic Control. J. Org. Chem. 1985, 50 (17), 3241-3.
  242. Liotta, D. New Organoselenium Methodology. Accounts Chem. Res., 1984, 17(1), 28-34.
  243. Liotta, D. The Chemistry of 2-Phenylselenenylenones. Proceedings of the Fourth International Conference on the Organic Chemistry of Selenium and Tellurium 1983, 278-96.
  244. Goldsmith, D.; Liotta, D.; Saindane, M.; Waykole, L.; Bowen, P. 3-Alkylfurans as Useful Synthetic Equivalents for Substituted D2-Butenolides. Tetrahedron Lett. 1983, 24(52), 5835-8.
  245. Liotta, D.; Arbiser, J.; Short, J.; Saindane, M. A Simple, Inexpensive Procedure for the Large Scale Production of Alkyl Quinones. J. Org. Chem. 1983, 48 (17), 2932-33.
  246. Liotta, D.; Saindane, M.; Waykole, L. New Probes for Electron Transfer Processes. Evidence Supporting the Single Electron Transfer Mechanism in Additions of Carbanions to Dienones. J. Am. Chem. Soc. 1983, 105 (9), 2922-3.
  247. Liotta, D.; Saindane, M.; Ott, W. A Simple, Efficient Synthesis of 3-Substituted Furans. Tetrahedron Lett. 1983, 24 (24), 2473-6.
  248. Menger, F.; Grossman, J.; Liotta, D. Transition State Pliability in N-to-N Proton Transfer. J. Org. Chem. 1983, 48 (6), 905-7.
  249. Lehman, T.; Bursey, M.; Harvan, D.; Hass, J.; Liotta, D.; Waykole, L. Identity of Collisional Activation Spectra of Some Positive Ions Produced Both by Reversal of Negative Ions and by Decomposition of Positive Ions. Org. Mass. Spec. 1982, 17 (12), 607-11.
  250. Liotta, D.; Sunay, U.; Ginsberg, S. Phosphonosilylations of Cyclic Enones. J. Org. Chem. 1982, 47(11), 2227-9.
  251. Liotta, D.; Saindane, M.; Brothers, D. Base-induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47(8), 1598-1600.
  252. Liotta, D.; Zima, G.; Saindane, M. The Origins of Regio- and Stereoselectivity in Additions of Phenylselenenyl Chloride to Allylic Alcohols and the Applicability to These Additions to a Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1982, 47(7), 1258-67.
  253. Baker, A.; Horozoglu, G.; Guang-Di, Y.; Liotta, D.; Zima, G.; Barnum, C.; Flannagan, N. The Photoelectron Spectra of Alkyl Aryl Selenides. Electronic and Steric Factors in the Observation of Rotamers. J. Org. Chem. 1981, 46(21), 4127-30.
  254. Liotta, D.; Barnum, C.; Saindane, M. Synthetic Applications of 2-Phenylselenenylenones. 2. The Synthesis of Dihydrojasmone and cis-Jasmone. J. Org. Chem. 1981, 46 (21), 4301-4.
  255. Liotta, D.; Saindane, M.; Barnum, C.; Ensley, H.; Balakrishan, P. Reactions Involving Selenium Metal as an Electrophile. 2. A General Procedure for the Preparation of Unsaturated b- Dicarbonyl Compounds. Tetrahedron Lett. 1981, 22 (32), 3043-6.
  256. Liotta, D.; Saindane, M.; Barnum, C. Selective Reactions of Carbanions with p-Quinones. The Aggregate Model. J. Org. Chem. 1981, 46 (16), 3369-70.
  257. Liotta, D.; Sunay, U.; Santiesteban, H.; Markewicz, W. Phenyl Selenide Anion. A Superior Reagent for SN2-Type Cleavages of Esters and Lactones. J. Org.Chem. 1981, 46 (13), 2605- 10.
  258. Liotta, D.; Barnum, C.; Puleo, R.; Zima, G.; Bayer, C.; Kezar, H. A Simple Method for the Efficient Synthesis of Unsaturated b-Dicarbonyl Compounds. J. Org. Chem. 1981, 46(14), 2920-3.
  259. Liotta, D.; Saindane, M.; Barnum, C. Diels-Alder Reactions Involving Cross-Conjugated Dienones. Effects of Substitution on Reactivity. J. Am. Chem. Soc. 1981, 103(11), 3224-6.
  260. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-ray Excitation. Anal. Chem. 1980, 52(5), 161R-174R.
  261. Liotta, D.; Zima, G.; Barnum, C.; Saindane, M. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation, Tetrahedron Lett. 1980, 21 (38), 3643-6.
  262. Liotta, D.; Zima, G.; Barnum, C. Synthetic Applications of 2-Phenylselenenylenones. Selective Formation of Exocyclic or Endocyclic Enones from a Common Intermediate, J. Org. Chem. 1980, 45, 2736.
  263. Liotta, D.; Zima, G. Synthetic Applications of Phenylselenenyl Chloride Additions. A Simple 1,3- Enone Transposition Sequence. J. Org. Chem. 1980, 45 (13), 2551-3.
  264. Goldsmith, D.; Liotta, D.; Lee, C.; Zima, G. The Reactions of β,γ-Unsaturated Acids with Phenylselenenyl Chloride. Decarboxylative Elimination vs. Phenylselenolactonization. Tetrahedron Lett. 1979, 50, 4801-4.\
  265. Zima, G.; Liotta, D. A General Synthesis of 2-Phenylselenenylenones. The Reactions of Unsaturated Ketones with a Phenylselenenyl Chloride/Pyridine Complex. Synth. Commun. 1979, 9 (8), 697-703.
  266. Liotta, D.; Paty, P.; Johnson, J.; Zima, G. Synthetic Applications of Phenyl(trimethylsilyl)selenide, Tetrahedron Lett. 1978, 51, 5091-4.
  267. Liotta, D.; Zima, G. An Examination of the Synthetic Utility of Phenylselenenyl Chloride Additions to Olefins. Tetrahedron Lett. 1978, (50), 4977-80.
  268. Baker, A.; Wong, D.; Lo, S.; Bloch, M.; Horozoglu, G.; Goldman, N.; Engel, R.; Liotta, D. The Reaction N-Aryl Nitrones with Dichloroketene: A New Synthesis of Isatins. Tetrahedron Lett. 1978, 215.
  269. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-Ray Excitation. Anal. Chem. 1978, 50 (5), 328R-46R.
  270. Liotta, D.; Markiewicz, W.; Santiesteban, H. The Generation of Uncomplexed Phenyl Selenide Anion and Its Applicability of SN2-Type Cleavages. Tetrahedron Lett. 1977, (50), 4365-8.
  271. Liotta, D.; Markiewicz, W.; Santiesteban, H. Nucleophilic Ring Opening of Lactones via SN2- Type Reactions with Uncomplexed Phenyl Selenide Anion. Tetrahedron Lett. 1977, (50) 4369- 72.
  272. Paquette, L.; Liotta, D.; Liao, C.; Wallis, T.; Eickman, N.; Clardy, J.; Gleiter,
  273. Endoperoxidation of Conformationally Fixed Norcaradienes by Singlet Oxygen. Frontier Molecular Orbital Basis for the Operability of 1O2 Quenching by Hydrazides. J. Am. Chem. Soc., 1976, 98 (20), 6413-16.
  274. Paquette, L.; Liao, C.; Liotta, D.; Fristad, W. Reversal of Stereospecificity During Allylic Hydroperoxidation of D3-Norcarene and Bicyclo [4.2.0] Oct-3-ene Derivatives Arising from Structurally Enforced Quenching of Singlet Oxygen by the Hydrazide Functionality. J. Am Chem. Soc. 1976, 98 (20), 6412-14.
  275. Paquette, L.; Liotta, D.; Baker, A. Frontier Molecular Orbital Basis for the Structurally Dependent Regiospecific Reactions of Singlet Oxygen with Polyolefins. Tetrahedron Lett. 1976, (31), 2681-4.
  276. Baker, A.; Brisk, M.; Venanzi, T.; Kwon, Y.; Sadka, S. Spiroconjugation Involving Sulfur 3p Atomic Orbitals. Tetrahedron Lett. 1976, 17 (38), 3415-18.
  277. Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet Excitation. Anal. Chem. 1976, 48, 281R-94R.
  278. Liotta, D.; Engel, R. The Thermal Decomposition of Alkoxycarbonyl Thiocyanates and Isothiocyanates. Can. J. Chem. 1975, 53, 907-12.
  279. Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. The Reactions of N-Aryl Nitrones with Oxalyl Chloride. J. Org. Chem. 1974, 39 (13).
  280. Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. 1. Selective Ortho-Chlorination in the Reaction of Aryl Nitrones and Amine Oxides with Thionyl Chloride or Phosgene. J. Org. Chem. 1974, 39(18).
  281. Liotta, D.; Baker, A.; Goldman, N.; Weinstein, F.; Felsen, D.; Engel, R. The Reaction of N-Aryl Nitrones with Thionyl Chloride or Phosgene. J. Org. Chem. 1973, 39, 3445.
  282. Engel, R.; Santo, T.; Liotta, D.; Freed, D. Enhanced Nucleophilic Displacement in Phosphinite Esters. Chem. Commun. 1970, 646a.
  283. Engel, R.; Liotta, D. The Thermal Decomposition of Trialkyl Phosphorothioates. J. Chem. Soc. C, 1970, 523.


  1. NMDA receptor antagonists for neuroprotection. U.S. Patent 9,079,852. 2015. Liotta, D.; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Myers, S.; Tahirovic, Y.
  2. Chemokine CXCR4 receptor modulators and used related thereto. U.S. Patent 8,969,381. 2015. Wilson, L.; Wiseman, J.; Liotta, D.; Natchus, M.
  3. Subunit selective NMDA receptor potentiators for the treatment of neurological conditions. U.S. Patent 8,822,462 2014. Liotta, D.; Traynelis, S.; Santangelo, R.; Garnier; E.
  4. Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds. US Patent 8,507,673 2013. Liotta, D.; Snyder, J.; Jogalekar, A.; Barrett, A.; Fuchter, M.; Cook, M.; Kroll, S.
  5. NMDA receptor antagonists for neuroprotection. US Patent 8,420,680 2013. Liotta,
D.;; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Tahirovic, Y.; Myers, S.
  6. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. US Patent 8,193,249 2012. Liotta, D.; Wang, S.; Snyder, J.; Venkatesan, H.
  7. 2-fluoronucleosides. US Patent 8,168,583 2012. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
  8. 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation. US Patent 8,114,994 2012. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.
  9. CXCR4 antagonists for the treatment of medical disorders. US Patent 8,114,884 2012. Liotta, D.; Shim, H.; Snyder, J.; Zhan, W.; Liang, Z.
  10. CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders. US Patent 8,080,659 2011. Liotta, D.; Snyder, J. and Zhan, W.
  11. Selective inhibitors for cyclin-dependent kinases. U.S. Patent 8,067,424. 2011. Liotta, D.; Jogalekar, A.; Snyder, J.; Barrett, A.; Coombes, R.; Ali, S.; Siwicki, A.; Brackow, J.; Scheiper, B.
  12. 2′-fluoronucleosides. U.S. Patent 7,662,938. 2010. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
  13. HIV-1 mutations selected for by beta-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,635,690. 2009. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.
  14. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 7,577,139. 2009. Liotta, D.; Venkatesan, H.; Snyder, J.; Wang, S.
  15. 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation. U.S. Patent 7,495,006. 2009. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.
  16. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,468,436. 2008. Liotta, D.; Schinazi, R.; Choi, W.
  17. 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 7,419,966. 2008. Liotta, D.; Schinazi, R.
  18. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3- oxathiolane. U.S. Patent No. 7,402,588. 2008. Liotta, D.; Schinazi, R.; Choi, W.
  19. pH-dependent NMDA receptor antagonists. U.S. Patent No. 7,375,136. 2008. Liotta, D.; Traynelis, S.; Snyder, J.; Altas, Y.; Mott, D.; Doherty, Jr, J.; Dingledine, R.
  20. Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 7,371,766. 2008. Liotta, D.; Snyder, R.; Davis, M., Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.
  21. 2′-fluoronucleosides. U.S. Patent 7,307,065. 2007. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
  22. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,160,999. 2007. Liotta, D.; Schinazi, R.; Choi, W.
  23. HIV-1 mutations selected for by beta.-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,115,584. 2006. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.
  24. Therapeutic nucleosides. U.S. Patent No. 7,053,100. 2006. Liotta, D.
  25. Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono- isopropoxide. U.S. Patent No 6,939,965. 2005. Liotta, D.; Painter, G.; Almond, M.; Soria, J.; Sznaidman, M.
  26. 2′-fluoronucleosides. U.S. Patent 6,911,424. 2005. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
  27. Therapeutic nucleosides. U.S. Patent No. 6,812,233. 2004. Liotta, D.
  28. Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 6,777,441. 2004. Liotta, D.; Wang, E.; Snyder, J.; Venkatesan, H.
  29. Diimino compounds for use as modulators of cell regulation. U.S. Patent 6,750,211. 2004. Liotta, D.; Merrill, A.; Warden, L.
  30. Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No. 6,720,184. 2004. Liotta, D.; Merrill, Jr., A.;; Wang, E.; Riley, R.
  31. Method of Resolution and Antiviral Activity of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 6,703, 396 B1. 2004. Liotta, D.; Schinazi, R.; Choi, W.
  32. 3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith. U.S. Patent No. 6,680,303. 2004. Liotta, D.; Schinazi, R.
  33. Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 6,664,272. 2003. Liotta, D.; Snyder, J.; Davis, M.; Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.
  34. Antiviral Activity and Resolution of 2-Hydroxymethyl-5-(5-Fluorocytosin-1-YL)-1,3. US Patent 6,642,245, B1 2003. Liotta, D.
  35. Sphingolipid Derivatives and Their Methods of Use. US Patent 6,610,835, 2003. Liotta, D.; Merrill, A.; Keane, T.; Schmelz, E.; Bhalla, K.
  36. Method for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,583,292. 2003. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
  37. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,576,776. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
  38. Diiminopiperazine derivatives for use in the modification of sphingolipid metabolism and as modulators of cell regulation. U.S. Patent 6,552,025, 2003. Liotta, D.; Merrill, A.; Warden, L.
  39. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,518,425. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
  40. Compositions and Methods for Targeting Phamaceutically Active Materials to Cells Containing Androgen Receptors. US Patent 6,468,981, 2002. Liotta, D.; Petros, J.
  41. Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,399,783. 2002. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
  42. 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 6,391,859, 2002. Liotta, D.; Schinazi, R.
  43. 2′-Fluoronucleosides. U.S. Patent No. 6,348,587. 2002. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
  44. Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers. U.S. Patents 6,346,627. 2002. Liotta, D.; Schinazi, R.; Choi, W.
  45. Treatment of HIV by administration of beta.-D-2′, 3′-didehydro-2′,3′-dideoxy-5- fluorocytidine (D4FC). U.S. Patent No. 6,232,300. 2001. Liotta, D.; Schinazi, R.
  46. Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,215,004. 2001. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
  47. Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 6,153,751. 2000. Liotta, D.; Choi, W.
  48. Polycationic oligomers. U.S. Patent No. 6,153,596. 2000. Liotta, D.; Petros, J.; Wey, S.; Karr, J.; Pohl, J.
  49. Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent 6,150,537. 2000. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
  50. Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No 6,127,578. 2000. Liotta, D.; Merrill Jr., A.; Wang, E.; Riley, R.
  51. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3- oxathiolane. U.S. Patent No. 6,114,343. 2000. Liotta, D.; Schinazi, R.; Choi, W.
  52. Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 6,069,252. 2000. Liotta, D.; Schinazi, R.; Choi, W.
  53. Diastereoselective synthesis hydroxyethylene dipeptide isosteres. U.S. Patents No. 5,990,341. 1999. Liotta, D.; Lagu, B.
  54. Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 5,914,400. 1999. Liotta, D.; Choi, W.
  55. Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3- oxathiolane. U.S. Patents 5,914,331. 1999. Liotta, D.; Schinazi, R.; Choi, W.
  56. [5–Caboxamido or 5–fluoro]–[2′, 3′–unsaturated or 3′–modified]–pyrimidine nucleosides. U. S. Patent No. 5,905,070. 1999. Liotta, D.; Schinazi, R.
  57. Treatment of Urogenital Cancer with Boron Neutron Capture. U.S. Patent 5,872,107, 1999. Liotta, D.; Schinazi, R.; Keane, T.
  58. Method of Resolution and Antiviral Activity of 1.3-Oxathiolane Nucleoside Enantiomers. U.S. Patent 5,892,025, 1998. Liotta, D.; Schinazi, R.; Choi, W.
  59. Antiviral 1.3-Dioxolane Nucleoside Analogues. U.S. Patent 5,852,027, 1998. Liotta, D.
  60. Method of resolution of 1,3-oxathiolane nucleoside enantiomers. U. S. Patent 5,827,727. 1998. Liotta, D.; Schinazi, R.; Choi, W.; Cheng, Y.
  61. Method for the synthesis, compositions and use of 2′-deoxy-5-fluoro-3′-thiacytidine and related compounds. U.S. Patent 5,814,639. 1998. Liotta, D.; Schinazi, R.; Choi, W.
  62. Method of Resolution of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 5,728,575, 1998. Liotta, D.; Choi, W.
  63. Compositions Containing 5-Fluoro-2’,3’-Didehydro-2’,3’-Dideoxycytidine Or A Mon-, Di-, Or Triphosphate Thereof And A Second Antiviral Agent. US Patent 5703058, 1997. Liotta, D.; Schinazi, D.
  64. Method for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacyctidine and Related Compounds. U.S. Patent. 5,700,937, 1997. Liotta, D.; Choi, W.; Schinazi, R.
  65. One Vessel Stereoselective Glycosylation of Purines and Pyrimidines. U. S. Patent 5,602,245, 1997. Wurster, J.; Wang, J.; Wilson, L.
  66. Treatment of urogenital cancer with boron neutron capture therapy. U.S. Patent 5,599,796. 1997. Liotta, D.; Schinazi, R.; Keane, T.
  67. Diastereoselective synthesis of hydroxyethylene dipeptide isosteres. U.S. Patent 5,587,514. 1996. Liotta, D.; Lagu, B.
  68. Method and Composition for the Synthesis of BCH-189 and Related Compounds. European Patent 5,539,116, 1996. Liotta, D.; Choi, W.
  69. 4-Arylisoindole Analgesics. U.S. Patent 5,508,424, 1996. Liotta, D.; Carmosin, R.; Carson, J.; Pitis, P.; Raffa, R.
  70. Sensitizing agents for use in boron neutron capture therapy. U.S. Patent No. 5,462,724. 1995. Liotta, D.; Schinazi, R.
  71. Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,432,273, 1995. Liotta, D.; Hager, M.
  72. Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,414,078, 1995. Liotta, D.; Hager, M.
  73. Novel Sensitizing Agents for Boron Neutron Capture Therapy. U.S. Patent No. 5,405,598, 1995. Liotta, D.; Schinazi, R.
  74. Methods of Synthesis of 1,3-Dioxolane Nucleosides. U. S. Patent No. 5,276,151, 1994. Liotta, D.
  75. Method of Altering Sphingolipid Metabolism and Detecting Fumonisin. U.S. Patent 5,232,837, 1993. Liotta, D.
  76. Methods for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacytidine and Related Compounds. U. S. Patent No. 5,210,085 1993. Liotta, D.; Schinazi, R.; Choi, W.
  77. Method and Compositions for the Synthesis of BCH-189 and Related Compounds. U. S. Patent No. 5204466, 1993. Liotta, D.; Choi, W.
  78. Method of Preparing Sphingosine Derivatives. U. S. Patent 5,110,987, 1992. Liotta, D.; Merrill, A.
  79. 1,2-1,4 Addition Reaction Sequence Leading to Diphenylacetylenes. U.S. Patent 4,772,755 1988. Liotta, D.; Maryanoff, C.; Paragamian, V.