https://scholarblogs.emory.edu/liotta/
Born: January 31, 1949
Brooklyn, N.Y.
Married, two sons
EDUCATION
Queens College of CUNY, B.A., 1970
The City University of New York: Ph.D., with R. Engel, 1974
The Ohio State University: Postdoctoral, with L. Paquette, 1974-1976
EXPERIENCE, HONORS, AWARDS
Assistant Professor of Chemistry, Emory University, Atlanta, Ga., 1976-1982; Associate Professor, 1982-1988; Professor, 1988-present; Samuel Candler Dobbs Professor of Chemistry, 2000-present; Department Chairman, 1993-1996
Fellow of the Alfred P. Sloan Foundation, 1980-1984
Recipient of a Camille and Henry Dreyfus Teacher Scholar Fellowship, 1981-1986
Alexander von Humboldt Senior Scientist Fellow, 1994-1996
Emory Williams Distinguished Teaching Award for the Natural Sciences, Emory University; 1987
Co-Chair, National Science Foundation Workshop on Reactive Intermediates, 1980-1983
Co-Chair, Gulf Coast Chemistry Conference, 1981-2007
Co-Chair, The Latest Trends in Organic Synthesis Symposia – 1986–2000
Chair, Symposium on Molecular Modeling, SERMACS 88, Atlanta, GA, 1988
Chair, Symposium on Molecular Modeling, Molecular Design, Ltd., Murray Hill, NJ, 1989
Chair, Gordon Conference on Heterocyclic Chemistry, 1989
Editor, “Organoselenium Chemistry,” Wiley- Interscience, 1987
Editor, Tetrahedron “Symposium in Print” -“Recent Aspects of Organoselenium Chemistry”
Editor, Advances in Molecular Modeling, Vol. 1, 2 and 3, JAI Press, 1988, 1990, 1995
Editor (with M. Volmer), Organic Syntheses Reaction Guide, Wiley- Interscience, 1991
Editor (with V. Cornel), Recent Reviews, The Journal of Organic Chemistry, 1995–1999
Member of the Board of Editors, Encyclopedia of Reagents for Organic Synthesis, Wiley- Interscience, 1992–1997
Consultant, R. W. Johnson Pharmaceutical Research Institute 1985–2000
Consultant, Glaxo Group Ltd. (United Kingdom), 1991-1993
Consultant, Burroughs Wellcome (Glaxo Wellcome), 1992-1996
Consultant, The Wellcome Research Foundation Ltd. (United Kingdom), 1992-1995
Consultant, Boehringer Ingelheim, 1994–2000
Consultant, BioMega (Montreal), 1993-1997
Member, Scientific Advisory Board, AtheroGenics, 1995–2007
Member, Scientific Advisory Board, Triangle Pharmaceuticals, 1995–1998
Chair, Scientific Advisory Board, Triangle Pharmaceuticals, 1998–2003
Instructor, American Chemical Society Short Course on Molecular Modeling, Athens, GA, 1988–2000
Chairman, Georgia Section, American Chemical Society, 1988
Vice President for Research, Emory University, Atlanta, GA, 1996-2000
Member, Executive Committee, Division of Organic Chemistry, American Chemical Society, 1990-1992; Secretary-Treasurer, 1994-1997
Ad Hoc Member, Medicinal Chemistry Study Section, The National Institutes of Health, 1988, 1994
Ad Hoc Member, Bioorganic and Natural Products Study Section, The National Institutes of Health, 1992
Ad Hoc Member, Personnel C Advisory Panel, The American Cancer Society, 1993-1994
Member, Drug Discovery Study Section, The American Cancer Society, 1995-2006
Member, AIDS and Related Research Study Section, National Institutes of Health, 1995-1997; Chair, 1997-1998
Director, Molecular Therapeutics Program, Winship Cancer Center, 1994–2000
Member, External Advisory Committee, University of Alabama, Birmingham, Center for AIDS Research, 1996-2001
Member, Executive Committee, MSP, DGBBS, 2001-2007
Co-Director, Knowledge Transfer, Center for Behavioral Neuroscience, 1999-2001
Member, Board of Directors, F.O.B. Synthesis, Inc., 2001-present
Biomedical Industry Growth Award recipient, Georgia Biomedical Partnership, 2003
Member, Scientific Advisory Board, Chimerix, Inc., 2003-present
Member, Scientific Advisory Board, Slainte Bioceuticals, Inc. , 2003-2007
Fellow, American Association for the Advancement of Science, 2003-present
Chair, Scientific Advisory Board, iThemba Pharmaceuticals, 2001-present
Member, Scientific Advisory Board, MetaStatix, Inc., 2005-2008
Herty Award Recipient, Georgia Section of the ACS, 2005
Member, Scientific Advisory Board, University of Pittsburgh Center for Chemical Methodologies & Library Development, 2005-2013
Member, University of Georgia Center for Drug Discovery, 2005-present
Distinguished Faculty Lecturer, Emory University, 2006
Member, Board of Directors, Georgia Advanced Technology Ventures 2006-present
Director, RSA Drug Discovery Training Program, 2007-present
Member, Board of Directors, Achilion Pharmaceuticals, 2008-present
Member, Scientific Advisory Board, Altiris, 2008-present
Director, Emory Institute for Drug Development, 2009-present
Co-Director, Emory Chemical Biology Consortium (NCI), 2009-present
Consultant, Cardioxyl Pharmaceuticals, 2009-present
Editor-in-Chief, Medicinal Chemistry Letters, American Chemical Society, 2010-present
Member, Biological Chemistry and Macromolecular Biophysics (BCMB) Study Section, The National Institutes of Health, 2010
Gisvold Award, Department of Medicinal Chemistry, University of Minnesota, 2010
Fellow, American Chemical Society, 2010-present
ACS Medicinal Chemistry Hall of Fame, 2010
Thomas Jefferson Award for Teaching, Emory University, 2011
Member, Scientific Advisory Board, Cerecor Inc, 2011-present
IP Legend Award, Georgia State University College of Law and J. Mack Robinson College of Business, 2011
175 Emory Historymakers Medal, 2012
Uncommon Courage Award, Queens College, 2012
Honorary Doctorate, Queens College, 2012
Honorary Doctorate, University of Queensland, Queensland, Australia, 2012
Distinguished Alumni Award, The Ohio State University, 2013
Fellow, National Academy of Inventors, 2013
Emory University Senate Lecture Series Panel, 2013
Licensing Deal of the Year, Emory Office of Tech Transfer, 2014
Fellow, Australian Academy of Technological Sciences and Engineering, 2014
Georgia Bio Shark Tank Winner, 2014
ACS-BMS Smissman Award, 2015
Antonín Holý Memorial Lecture Award, 20th International Conference on Antiviral Research/ISAR, 2015
PROFESSIONAL ORGANIZATIONS
American Chemical Society
American Association for the Advancement of Science
International Society for Antiviral Research
RESEARCH SUPPORT
ACTIVE
R01 A1028731-23 (Liotta Dennis) 01/01/2013-12/31/2017 1.35 Academic
NIH/NIAID $425,820.00 0.45 summer
Non-Carbohydrate Approaches to Anti-AIDS Nucleosides
Design & synthesis of novel nucleoside analogs with improved resistance profile
P30 AI050409 (Curran James Walter) 8/1/12012 – 07/31/2017 0.45 Academic
NIH/NIAD $1,469,736.00 0.15 summer
Emory Center for AIDS Research
R01AI071002-06A1 (Plemper Richard Karl) 07/01/2012-06/30/2017 0.30 Academic
NIH $301,136.00 0.10 summer
Developing Myxovirus Inhibitors with Expanded Pathogen Target Range
This project employs a structure-based drug design strategy to develop a novel class of MV fusion inhibitors to applicable antiviral drugs
29XS132 TO08 (Haian Fu) 06/24/2009-06/23/2014 .09 Academic
SAIC-FREDERICK $49,993.70 .03 summer
Emory Chemical Biology Discovery Center in the NCI Chemical Biology Consortium
The major goals of this project is to discover and develop new and innovative, targeted cancer therapies.
000021215 (Liotta Dennis) 01/01/2012-10/31/2013 0.45 Academic
BIO Ventures for Global Health $800,000.00 0.15 summer
Role: Principal Investigator
Global Health Primer
Web- based database tool to track work done in R&D related to neglected tropical disease
RECENT SUPPORT
R37 AI028431 (Liotta Dennis) 7/01/1989-4/30/2013 0.90 Academic
NIH/NIAID (Merit Award) $1,469,736.00/ NCE
Non-Carbohydrate Approaches to Anti-AIDS Nucleosides
Design & synthesis of novel nucleoside analogs with improved resistance profiles
DEPARTMENT AND UNIVERSITY DUTIES
Chair, Graduate Recruitment Committee, 1977-1987
College Curriculum Committee, 1981-1984
3-2 Cooperative Engineering Program Committee, 1982-1983
Graduate Student Teaching Award Committee, 1982-1984
Winston Churchill Scholarship Committee, 1982-1983
Arts and Sciences Computer Advisory Committee, 1982-1986
Stipe Society Award Selection Committee, 1982-1984
College / Dental School Cooperative Committee, 1982-1984
Pre-Medical/Pre-Dental Advisory Committee, 1982-1986
Faculty Advisor to Undergraduates, 1977-present
Director of Graduate Studies, 1983-1987
Graduate Executive Committee, 1983-1987; 1990-1992
Grievance Subcommittee, Graduate Executive Committee, 1985-1986
Committee on Evaluation of Teaching, 1985-1986
Policy and Procedure Subcommittee, Graduate Executive Committee, 1986-1987
Emory Graduate Dean Search Committee, 1988-1989
University Patent and Copyright Committee, 1988-1990
College Enrollment Committee, 1989 -1990
Emory / Georgia Tech Joint Ph. D. Committee, 1990-1993
College Nominating Committee, 1990, 1992
Responsibility in Research Task Force, 1990-1992
Emory College Dean Search Committee, 1990-1991
Chair, Chemistry Department Faculty Search Committee, 1990-1991
Graduate Executive Committee, 1990-1992
Chair, Chemistry Department Computer Committee, 1990-1993
University Research Committee, 1990-1993
Academic Computing Advisory Committee, 1992-1996
Chair, Chemistry Department Computer Committee, 1990-1993
Chemistry Department Undergraduate Education Committee, 1990-1996
Chair, Chemistry Department, 1993-1996
Graduate Dean Search Committee, 1994-1995
Structural Biology Eminent Scholar Search Committee (Biochemistry Dept.), 1994-1997
Associate V. P. for Institutional Advancement Search Committee, 1995
Director, Molecular Therapeutics Program, Winship Cancer Center, 1994
Member, President’s Senior Staff, 1996-1998
Member, Administrative Council, 1998
Member, Provosts’ Staff, 1996
Member, Trustees Executive Committee, 1996
Member, Executive Vice President for Health Affairs Advisory Committee, 1996
Chair, GMHI-Emory West Executive Committee, 1998
Co-Director, Knowledge Transfer, Center for Behavioral Neuroscience, 1999-2001
Associate Director for Research Development, Emory Center for AIDS Research, 2005-present Director Developmental Core, Emory CFAR, 2001-2005
Executive Committee, MSP, DGBBS 2001-2004
Chair, Faculty Science Council, 2004-present
Member, College Governance Committee, 2004
Member, Development and University Relations Faculty Council, 2005
Member, Global Health Institute Internal Advisory Committee, 2006-present
Member, Emory College of Arts & Science Dean Search Committee, 2009-2010
Member, Hightower Awards Committee, 2009
Member, Center for AIDS Research Program Council, 2010-present
Member, Chemistry Department Outreach Committee, 2012-present
RESEARCH INTEREST
Professor Dennis Liotta has helped to transform HIV/AIDS from a death sentence to a chronic infection in which patients are able to live active, near normal lives. The Emory Office of Technology Transfer estimates that greater than ninety per cent of all of the HIV-infected persons in the United States take (or have taken) one of the drugs he invented. In his current role as Executive Director of the Emory Institute for Drug Development, Dennis oversaw the discovery and development of another novel nucleoside analogue, EIDD-2023, as a potential treatment for single-stranded RNA viral infections. His research group has also recently discovered the first potent, dual tropic (CCR5/CXCR4) HIV entry inhibitor.
Over the past two and a half decades Dr. Liotta’s research has focused on the discovery and development of novel antiviral, anticancer and anti-inflammatory therapeutic agents. He is one of the leaders of the Emory team that discovered the antiviral drug, Emtriva (emtricitabine), which was approved for treating HIV in July 2003. Emtriva is a component of the ground breaking, once a day, triple combination therapy, Atripla, which is now universally accepted as the drug combination of choice for treating HIV infected patients. In addition, he is the inventor of record for several clinically important antivirals, including Epivir, Reverset, Racivir and Elvucitabine. He is also the lead inventor of Q-122, a safe, orally available clinical agent for controlling hot flashes in post-menopausal women.
For a description of Dr. Liotta’s current research interests, see his website: https://scholarblogs.emory.edu/liotta/
INVITED LECTURES
3rd Gulf Coast Chemistry Conference, Gulf Shores, AL
1980 Gordon Conference on Organic Reactions and Processes
University of Central Florida, Orlando
Symposium on Organic Reactions, Southeast-Southwest Regional ACS Meeting, New Orleans University of New Orleans, New Orleans, LA
Kennesaw College, Kennesaw, GA
NSF Workshop on Reactive Intermediates, Callaway Gardens, GA
Temple University, Philadelphia
University of Pennsylvania, Philadelphia
Clemson University, Clemson, SC
Symposium on Organoselenium Chemistry, 183rd National ACS Meeting, Las Vegas
Eastman Kodak Co., Kingsport, TN
Schering-Plough Corp., Bloomfield, NJ
Louisiana State University, Baton Rouge
Georgia State University, Atlanta
NSF Workshop on Synthesis and Natural Products Chemistry, Squam Lake, NH
NSF Workshop on Reactive Intermediates, Pingree Park, Colorado
Plenary Lecture, 4th International Conference on the Organic Chemistry of Selenium and Tellurium, Birmingham, England
NSF Workshop on Reactive Intermediates, Santa Catalina, CA
Brown University, Providence, RI
University of Virginia, Charlottesville
Florida State University, Tallahassee
Ohio State University, Columbus
Auburn University, Auburn, AL
Warner-Lambert/Parke-Davis, Ann Arbor, MI
ACS Creative Synthesis Symposium, St. Louis, MO
1st “Latest Trends in Organic Synthesis” Symposium, Virginia Polytechnic Institute, Blacksburg,
Monsanto Agricultural Products, St. Louis, Missouri.
University of South Florida, Tampa
Georgia Institute of Technology, Atlanta
College of Charleston, Charleston, SC
McNeil Pharmaceutical, Spring House, PA
University of Georgia, Athens
- I. Dupont, Wilmington, DE
1985 Gordon Conference on Heterocyclic Chemistry, New Hampton, NH
Burroughs Wellcome Corp., Research Triangle, NC
Eastman Kodak Co., Rochester, NY
University of Rochester, Rochester, NY
Schering-Plough Corp., Bloomfield, NJ
University of Maryland, College Park
Tulane University, New Orleans
Ortho Pharmaceutical, Raritan, NJ
The 2nd “Latest Trends in Organic Synthesis” Symposium, Virginia Polytechnic Institute, Blacksburg
McNeil Pharmaceutical, Spring House, PA
Florida State University, Tallahassee
Ortho Pharmaceutical, Raritan, NJ
Merck, Sharpe and Dohme, Rahway, NJ
Sandoz Research Institute, East Hanover, NJ
University of Michigan, Ann Arbor
American Association of Chemists, Atlanta
EXXON, Baton Rouge, LA
Burroughs Wellcome Corp., Research Triangle, NC
Philadelphia Organic Chemists Club (POCC), Philadelphia
University of Alabama, Tuscaloosa
BOC Group, Murray Hill, NJ
1989 Gordon Conference on Reactions and Processes, New Hampton, NH
The Squibb Medical Research Institute, Princeton, NJ
Molecular Design Ltd., Morristown, NJ
Hoffmann La Roche, Nutley, NJ
The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ
1989 Gordon Conference on Reactions and Processes, New Hampton, NH
University of Montreal, Montreal, Canada.
University of Waterloo, Waterloo, Canada.
BioMega, Inc., Montreal, Canada.
FMC Corporation, Princeton, NJ
State University of New York, Stony Brook, NY
SERMACS 89, Winston-Salem, NC
Glaxo Group Ltd., Greenford, England, UK.
Hoechst-Roussel Pharmaceutical, Somerset, NJ
Hunter College of CUNY, New York City
Lederle Laboratories, Pearl River, NY
University of Richmond, Richmond, Virginia
Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT
BioMega, Inc., Montreal, Canada
The R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ
Burroughs Wellcome Corp., Research Triangle, NC
Merck, Sharpe and Dohme, Rahway, NJ
Eli Lilly and Co., Indianapolis
5th International Symposium on Antiviral Research, Vancouver, BC, Canada
Ernest Guenther Award Symposium, San Francisco
Abbott Research Laboratories, Chicago
Sigma Xi / Interscience Council, West Georgia College, Carrollton, GA
Nucleoside Nucleotide Round Table, Park City, UT
Bristol-Myers Squibb, Wallingford, CT
BioMega, Inc., Montreal, Canada
North Carolina State University, Raleigh,
Clemson University, Clemson, SC
Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT
Queens College of CUNY, Queens
North Jersey ACS Organic Topical Group, South Orange, NJ
New York Academy of Science, Chemical Sciences Section, New York City
New York University, New York City
Merck, Sharpe and Dohme, Rahway, NJ
6th International Society on Antiviral Research Conference, Venice, Italy
University of Ferrara, Ferrara, Italy
The Wellcome Research Foundation, Beckenham, UK
Glaxo Group, Ltd., Greenford, UK
1993 Nucleoside Roundtable, Park City, UT
Bioorganic Symposium, The Chemical Society, Loch Tay, Scotland
Marion Merrell Dow, Cincinnati, OH
Southeast Regional Meeting, American Chemical Society, Johnson City, TN
Fisons Pharmaceuticals, Rochester, NY
University of Rochester, Rochester, NY
BioMega, Inc., Montreal, Canada
Miles Pharmaceuticals, New Haven, CT
University of Central Florida, Orlando
University of Wisconsin, Milwaukee, WI
Georgia Institute of Technology, Atlanta
The Dupont-Merck Pharmaceutical Co., Wilmington, DE
Medicinal Chemistry Symposium, Buffalo, NY.
Georgia Biomedical Partnership Executive Forum, Atlanta
1994 Gordon Conference on Heterocyclic Compounds, New Hampton, NH
The Upjohn Co., Kalamazoo, MI
BioMega, Inc., Montreal, Canada
Colorado State University, Fort Collins, CO
The University of Alabama, Birmingham, AL
American Cyanamide, Princeton, NJ
Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT
Ciba-Geigy, Summit, NJ
Symposium on Drug Design and Synthesis, American Chemical Society Meeting, Chicago
University of Louisville, Louisville, KY
Merck Research Laboratories, West Point, PA
University of Chicago, Chicago
American Institute of Chemists, Symposium on Education, Charlotte, NC
1996 Gordon Conference on Heterocyclic Compounds, New Hampton, NH
Merck Research Laboratories, West Point, PA
Instituto Di Ricerche Di Biologia Molecolare, Rome, Italy
Eli Lilly and Company, Indianapolis
BioMega, Inc., Montreal, Canada
Latest Trends in Organic Chemistry, Gainesville, FL
University of Mississippi, University, MS
Johnson & Johnson Focused Giving Scientific Symposium, New Brunswick, NJ
Bristol Myer Squibb, New Brunswick, NJ
10th International Conference on Antiviral Research, Atlanta
New York University, New York City
Proctor and Gamble, Norwich, NY
16th Int. Congress of Heterocyclic Chemistry, Bozeman, MT
University of Tennessee, Knoxville
Second International Conference on Therapies for Viral Hepatitis, Kona, Big Island, HI
Brigham Young University, Provo, UT
9th Chemistry as a Life Science Symposium, Merck, Rahway, NJ
11th International Conference on Antiviral Research, San Diego, CA
Novum Lecture in Organic Chemistry, Institute of Biosciences at NOVUM, Stockholm, Sweden
Biotechnology Industry Organization ’98 International Meeting, New York, NY
216th National American Chemical Society Meeting, Boston
Eighth Symposium on the Latest Trends in Organic Synthesis, Gainesville, FL
1st International Conference on Discovery & Clinical Development of Antiretroviral Therapies, St. Thomas, West Indies
3rd International Conference on Therapies for Viral Hepatitis, Maui, HI
13th International Conference on Antiviral Research, Baltimore
DIA Workshop on Pharmaceutical Research in Academic Health Centers: New Paradigms, Philadelphia
Recent Advances in the Medicinal Chemistry of Anti-Infective Agents: New Targets and Opportunities, Cambridge, UK
15th Winter Fluorine Conference, St. Petersburg, FL
Washington State University, Pullman, WA
HEP DART Conference, Maui, HI
Merck, Rahway, NJ
AtheroGenics, Atlanta
Pharmasset, Atlanta
Zygogen, Atlanta
XII International HIV Drug Resistance Workshop, Cabo San Lucas, Mexico
McGill University, Montreal, Quebec, Canada
HIV DART, Naples, FL
University of Minnesota, Minneapolis
10th Symposium on Latest Trends in Organic Synthesis, Gainesville, FL
GA Tech, Atlanta
GA Life Sciences Summit Panel on International Partnerships, Atlanta
BIO 03 – iThemba Pharmaceuticals, Atlanta
Novel Anti-HIV / HBV Analogs, Gilead Sciences, Foster City, CA
University of Stellenbosch, Stellenbosch, South Africa
Scios, Inc., Fremont, CA
Global Access to HIV AIDS Treatment Panelist, Atlanta
Medical University of South Carolina, Charleston
University of Illinois, Chicago
Auburn University, Auburn, AL
Winship Cancer Institute Drug Development and Pharmacogenomics Academy, Emory University, Atlanta
Heterocyclic Compounds, Gordon Research Conference, Salve Regina University, Newport, RI
Organic Colloquium, Proctor & Gamble, Cincinnati
Amgen, Santa Barbara, CA
Davidson College, Davidson, NC
Scripps’ Distinguished Lecturer Series, La Jolla, CA
Winter Conference on Medicinal and Bioorganic Chemistry, Clearwater, FL
Merck, Rahway, NJ
University of Kansas, Lawrence, KS
Bio2Biz, Durban, South Africa
BioDesign 2006, Atlanta
Mid-Atlantic Bio, Washington DC
Imperial College, UK
UNC, Chapel Hill
ACS National Meeting, Chicago
Emerson Symposium, Emory
MD/PhD Student Visit Keynote Address, Emory
Career Development Symposium, Emory
University of Pittsburgh
Johnson & Johnson, La Jolla, CA
New Jersey ACS Symposium, Somerset
ACS Academia / Industry Forum, Kennesaw State
Queen’s College, NY
American Medical Writers Association Conference, Atlanta
Georgia Life Sciences Summit, Atlanta
CCNE Distinguished Lecture, Winship Cancer Institute, Emory University, Atlanta
Family Weekend Presentation, Emory University, Atlanta
EGAP Panel, Emory University Law School, Atlanta
CU Roche, Boulder
UNC, Greensboro
ACS National Meeting, Philadelphia
ACS National Meeting, Salt Lake City
Leo Paquette Legacy Symposium, Columbus, OH
AACR Frontiers in Cancer Prevention Research Conference, DC
Emory-GA Tech Frontiers of Cancer Nanotechnology, Atlanta
University of South Florida, Tampa
USF Moffitt Cancer Center, Tampa
AACR Prevention Conference, Atlanta
ACS Robins Symposium, Salt Lake City
2nd Annual UNCG Symposium in Medicinal Biochemistry, UNC, Greensboro
Bio2Biz, Keynote Address, Durban, South Africa
Princeton University
Therapeutic Applications of Computational Biology and Chemistry 2010, UK
University of Minnesota, Minneapolis
University of Buffalo, Foster Colloquium
Oxford College Commencement Address, Oxford, GA
Third European Workshop in Drug Synthesis, University of Siena, Italy
Clinton Health Initiative Conference, DC
McGill University, Montreal
Merck, Kenilworth, NJ
2010 Institute for Translational Medicine and Therapeutics International Symposium, U of Penn School of Medicine
Funding, Organizational & Scientific Challenges for Neglected Diseases, Boston
The Role of Innovation in Addressing Global Health, US Department of State Symposium, DC
Temple University, Philadelphia
Keystone Symposium, Snowbird, UT
MIKI (Universities of Minnesota, Iowa, Wisconsin and Illinois) Conference, Keynote Speaker, University of Kansas, Lawrence
Vanderbilt University, Nashville
Singapore Management University, IIE Distinguished Speaker, Singapore
Organic Chemistry: Perspectives on the 21st Century IV, Fiji
Alabama Drug Discovery Alliance Symposium, Keynote Speaker, University of Alabama, Birmingham
International HIV & Hepatitis Virus Drug Resistance Workshop, Cabo San Lucas, Mexico
Accelerating IP and Innovation in South Africa, Cape Town
Emory University Pathology Department Grand Rounds Speaker
Drug Discovery in Academia, Johns Hopkins
AIDS @ 30, Harvard University
University of Queensland, Australia
ACS Philadelphia, 2012, Entrepreneurship Workshop
World International Patent Organization Re:Search Annual Meeting, Opening Remarks
ACS National Meeting, Entrepreneurship: Drug Discovery Innovation at Start-Up, Small and Medium-Sized Biotechnology
UNISA, The In-House Management of Inventions and Patents, Pretoria, South Africa
Grand Rounds, Emory School of Medicine
Creating and Leveraging IP in Developing Countries: A Power Tool for Economic and Social Growth, Durban, South Africa
SERMACS, Plenary Lecture and Undergraduate Keynote, Atlanta
ACS, Presidential Symposium on Entrepreneurship, National Meeting, Indianapolis
ACS, Entrepreneurial Skills Interactive Symposium/Workshop, National Meeting, Indianapolis
Department of Medicine Leadership Retreat, Emory University
R.R. Baker Lecture, UC, Santa Barbara
David Chu Lecture, UGA
University of Michigan, Medicinal Chemistry Department
University of Michigan, Center for the Discovery of New Medicines
National Medicinal Chemistry Symposium, Charleston
Latest Trends in Organic Synthesis, Brock University, Ontario
21st International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Poland
Southeastern Medical Scientist Symposium, Keynote Speaker, Emory
Africa: The Next Biotech Frontier, BIO International Convention, San Diego
Health Connect South, Atlanta
Ausbiotech 2014, National Conference
The Scripps Research Institute, La Jolla
Winters Lecture, Virginia Commonwealth University
The Charles Liotta Symposium; GA Tech
Nanjing University, Nanjing PRC
Fudan University Hospital, PRC
Georgia State University, Atlanta
University of Queensland, Australia
ITMAT Symposium, University of Pennsylvania
Frontiers in Medicinal Chemistry, Antwerp
University of North Carolina, Asheville
Preparing Future Innovators, Emory University
BIO, Philadelphia
Swedish Chemical Society Trends in Organic Chemistry; Stockholm
Innovation in Drug Discovery, NJACS; Somerset, NJ
Pacifichem 2015; Honolulu
TEACHING EXPERIENCE (Emory University)
Introductory Organic Chemistry Chem. 121, 122, 221, 221Z, 222
Structure Elucidation Chem. 228, 326
Advanced Organic Chemistry Chem. 323
Advanced Organic Chemistry Chem. 321
Advanced Organic Chemistry III Chem. 523
Advanced Organic Chemistry IV Chem. 524
Organic Photochemistry Chem. 471
Phosphorus Chemistry Chem. 471
Synthetic Strategies Chem. 471
Directed Studies (Variety of Topics) Chem. 397, 497
Introductory Organic Laboratory Chem. 121L, 122L,
Organic Preparations Chem. 275, 327R
Seminar Chem. 591, 791
Molecular Modeling Chem. 725
Drug Discovery Chem. 729R
UNDERGRADUATE RESEARCH STUDENTS
Kottmeier,Steven Malone, Thomas
Grimm, Susan Pacetti, Steven
Russell,Holly Karhalios, Peter
Arbiser, Jack* Flannagan, Nancy
Magruder, G. Brock Brown, Morris
Puleo, Robert Lovitt, Etta*
Wugalter, Barbara Kezar, Edwin
Rocklin, Mark Yasman, Jeffrey
Short, James Markiewicz, William
Cohen, Robert Santiesteban, Hector*
Paty, Phillip* Secosan, Craig
Jamison, Charles Barnum, Christopher
Grossman, Judy* Powell, Gwendolyn*
Ginsberg,Steven* Whitworth, Terry
Jackson, Karen Bernstein, Duane
Reiner, John Phillips, Preston*
Lee, Donna Bretan, Amy
Fivush, Adam* Carmicheal, Elizabeth*
Cronin, Christopher Lee, James M.*
Lloyd, Aaron Pentaleri, Michael*
Dhruv, Nikhita Howard, Nancy
Ginn, Neil Granock, Howard
Javier, Carolyn Livingston, Jenny
Sreeram, Gautam Heiss, Aaron
Ellison, Margaret Chaiyachati, Sukit
Surattamont, Surichya Reece, Gerry
Bien, Jeff Petty, Sandra
Morin, Gregory* Underwood, Robert
Lobben, Paul Zimring, James
Nettles, James* Denius, Theodore
Jordan, Briton Khoram, Aram Rodney
Daniels, Sam Hollings, Darius
Ko, Huei-Huei El Diery, Mark
Van Dinh, Long Lyalikov, Vladimir
Okor, Mamehri Taghechian, Shaya
Torabi-Parizi, Parizad Graham, Abigail
Lines, Daniel Raja , Shreya
Jia, Jenny Ryder, Chris
Borland, Johnathan Wojdylo, Julia
Dua, Shiv Beckett, Allison
Sruti Gupta Andrew Navia
Catherine Urbano
*BS/MS program.
GRADUATE RESEARCH STUDENTS
Name Degree Highest Degree or Current Location
Period Thesis Title
Santiesteban, Hector M.D.-Ph.D., Emory Univ. Medical
1976-1977 M.S. School
New Synthetic Transformations Involving Phenyl Selenide Anion.
Powell, Gwendolyn M. D. – Univ. of Miami Medical
1976-1977 M.S. School
. Director of Health Affairs, Glaxo, Inc.
Experiments Directed Toward the Synthesis of 7,7-Dimethylnorbornadiene.
Lovitt, Etta M.D., Emory Univ.Medical School
1977-1978 M.S. An Investigation of the Reactions of Singlet Oxygen with Non-conjugated Interacting Dienes.
Paty,Phillip M.D.-Ph.D., Stanford Univ. Medical
1977-1978 M.S. School
Synthetic Applications of Trimethylsilylphenylselenide.
Williams, Richard New England Nuclear
1976-1979 M.S. Photooxygenation Reactions in Perfluorohydrocarbon Media.Phenylselenenly Enoates.
Zima, George Tennessee Eastman
1976-1980 Ph.D. Modern Organoselenium Chemistry.
Ginsberg, Steven M.D., Downstate Medical Center
1979-1980 M.S. Application of Diethyltrimethylsilyl Phosphite as a Reagent for Umpolung.
Grossman, Judy Molecular Design, Ltd.
1979-1980 M.S. An Investigation of Reactions of Anions with Selenium Metal.
1980-1985 Ph.D. Theoretical Explorations of Diastereoselectivity, Reactivity and Reaction Trajectories
Barnum, Christopher Dupont
1977-1981 Ph.D. 1. New Organoselenium Methodology. 2. Diels-Alder Reactions of Cross-Conjugated Dienones.
Reyes, Augustin Augustin W. Reyes Perfume Co.
1979-1981 M.S. Synthesis and Reactions of Phenylselenenly Enoates.
Sunay, Ustun Atlanta
1979-1984 Ph.D. 1. New Synthetic Methodology. 2. Exploratory Studies Directed Towards The Total Synthesis of Forskolin.
Arbiser, Jack Enders Children’s Hospital
1982-1983 M.S. 1. A Simple, Inexpensive Procedure for the Large-Scale Production of Quinones. 2. Synthesis of Selenated Heterocycles
Luce, Hudson Ph, D., Univ. of Fla.,
1981-1982 M.S. 1. A Study in the Selective Enolization of a Series of 10-Methyl-3-Decalones. 2. Conformational Energies of a Series of Allylic and Homoallylic Alcohols.
Waykole, Liladhar Sandoz Research Institute
1980-1984 Ph.D. Carbanion Reactions: Mechanisms and New Methodology.
Ott, Walter Lecturer – Emory Univ.
1981-1986 Ph.D. Methodologies Toward the Total Synthesis of Pallescensin A and Model Studies of the Quassinoid Bruceantin.
Jamison, W. Charles Patent Attorney
1981-1987 Ph.D. 1. Approaches to the Total Synthesis of the Diterpene Marrubiin. 2. Ligand Assisted Nucleophilic Addition. 3. Coal Processing in a Non-dissolving Medium.
Dunams, Tambra Tennessee Valley Authority
1982-1988 Ph. D. 1. New Methods for the Synthesis of Substituted Furans. 2. Hydrophobicity Effects in Diels-Alder Reactions. 3. Approaches to the Synthesis of Lasalocid A Analogs.
Hoekstra, William R. W. Johnson Pharmaceutical
1982-1986 Ph.D. Research Inst.
- New Organoselenium Methodology. 2. Studies Directed Towards The Total Synthesis of the Natural Product Forskolin.
Solomon, Mark Mobay, Inc.
1983-1988 Ph.D. 1. A Mechanistic Study of the Alkylation of Selenium-Substituted Enolates. 2. Ligand Assisted Nucleophilic Additions: Scope and Limitations.
McCormick, Michael Lecturer, Department of Chemistry,
1983-1993 M.S. Emory University
Stephens, Julie Theragenics Corporation
1983-85 M.S. Trajectories of Proton Transfer Reactions: Proton Transfer at an Acute Angle
Monahan, Robert MD, Columbus, GA
1984-1988 Ph.D. 1. Stereochemistry of Electrophile-Induced Cyclizations. 2. An Investigation of the Intramolecular Alkoxypalladation Carbonylation Reaction. 3. Synthesis of Phorbol-13-O-(3′-Dansylamino)-tetradecanoyl Acetate.
Brown, David Hoechst-Celanese
1982-1986 Ph.D. 1. New Oxidative Rearrangement Methodology. 2. Mechanistic Studies of Quinone Diels-Alder Reactions.
Nimkar, Sanjay University of Kansas
1985-1990 Ph.D. 1. Syntheses of Sphingosine Analogs and Its Derivatives. Stereoselective Syntheses of Sphingosines. 2. Approaches Toward the Total Syntheses of Royleanaone and Taxodione.
Menaldino, David VP of Research, F.O.B. Synthesis,
1986-92 Ph.D. Atlanta
Asymmetric Syntheses of Amino Alcohols as Bioactive Compounds.
Sisti, Nicholas Napro Biopharmaceuticals
1986-1987 M.S. Phospholipids: Form, Function and Synthesis.
Sperka, James Masters Program in Chemistry,
1986-1994 M.S. (deceased) Emory University
Swiss, Kevin Postdoctoral Fellow; University of
1987-1991 Ph.D. Illinois
Mechanism and Synthetic Methodology of the Ligand Assisted Nucleophilic Addition Process.
Mohan, Julie Glaxo, Inc.
1987-1989 M.S. 1. Factors Affecting Mono- and Di-additions of Carbanions to Quinones and Related Species. 2. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation.
Hager, Michael F.O.B. Synthesis, Atlanta
1987-1993 Ph.D. Approaches to 3′-Substituted 2′,3′-Dideoxynucleosides Starting from Non-Carbohydrate Precursors: The Synthesis of 3′-Azido-3′-deoxythymidine and 3′-Fluoro-3′-deoxythymidine.
Hinkley, William Glaxo Wellcome, Inc.
1987-1991 M.S. 1. Intramolecular Diels-Alder Reaction Rate Enhancement Due to Ethylene Glycol Solvation Effects. 2. Synthesis of Dihydrothiazine Oxide Fungicieds Via Intramolecular Hetero Diels-Alder Methodology. 3. Cuprate Additions to Quinol Alkoxides.
Strange, Luise Dekalb College
1988-1992 M.S. 1. Review of Literature Involving the Use of Enzymes in Organic Synthesis and Utilization of Organic Solvents to Improve Enzymatic Reactions. 2. Application of Enzymatic Technology Toward Specific Target Molecules Related to the Antiviral Compounds 2’,3’-Dideoxy-3’-thiacytidine and 2’,3’-Dideoxy-5-fluoro-3’ thiacytidine.
Morin, Gregory Doctoral Prog in Chemistry, Notre
1991-1992 M.S. Dame University
A Study of the Stereochemical Consequences of Nucleophilic Michael Additions to a g-Butenolide Directed Towards the Synthesis of Novel Nucleosides.
Wurster, Julie Postdoctoral Fellow; U. of California,
1988-1994 Ph.D. Irvine
. Stereoselective Metonds For 2’, 3’-Dideoxynucleoside Preparation: Purine Nucleoside Glyosylation and 3’-Functionalization of Nucleoside Precursors
Geisler, Victoria J. Professor and Chair; Department of 1984-1991 Ph.D. Chem.
West Georgia College
Part I. Actinomysin D-Inspired DNA Binding
Compounds. Part 2. Evaluation of the Role of
Intramolecular Hydrogen-Bonding and PKa of Long-Chain Bases on the Inhibition of Protein Kinase C.
Wilson, Larry Proctor and Gamble
1988-1992 Ph.D. Pharmaceuticals.
A Stereoselective Approach to 2′,3′-Dideoxynucleosides. Stereoselective Sulfenylation and Nitrogen Glycosylation Reactions.
Jones, Deborah Postdoctoral Fellow; Yale University
1989-1994 Ph.D. Site Head and Director Cheminformatics, GSK
Theoretical Investigations Aimed At Elucidating the Origins of Stereoselectivity A Three Case Study
Mills Crane, Heidi Sphinx Pharmaceutical
1990-1993 M.S. Stereoselective Syntheses and Stereochemical Evaluation of Various Sphingolipids
Spurling, Travis Novel Approaches Towards to
1990-1997 Ph.D. Treatment of
HIV Infection
Gall, John EPA / Dekalb College
1990-1993 M.S. Part I: Review of the Literature dealing with the Syntheses of 2’,3’-dideoxy and 2’,3’-Dideoxy-2’,3’-Didehydronucleosides.
Part II: Attempted Syntheses of 2’,3’- Didreoxypyrimidines via Intramolecular N-Glycosylation
Xia, Jianhui Doctoral Program, Carnegie-Melon
1991-1995 M.S. University
Voronkov, Michael Postdoctoral Fellow;
1991-1997 Ph.D. Part I: Synthesis of Novel Nucleoside Analogues as Potent Anti-HIV Agents: Part II: Preparation and Synthetic Studies of Novel Taxol Analogues
Goh, Jane Postdoctoral Fellow;
1992-1997 Ph.D. Diastereoselective Reactions of
-Dibenzylamino Carbonyl Compounds
Captain, Laura Postdoctoral Fellow; UNC, Chapel
1992-1997 Ph.D. Hill
Part I: Diastereroselective Conjugate Addition Reactions to a Novel 3-Ketoacrylate System for the Synthesis of HIV-1 Protease Inhibitors. Part II: A Novel Approach to Taxol Semisynthesis Utilizing Oxygen-Substituted Ketenes
Johnston, Lisa Unknown
1994-1998 Ph.D.
McAtee, Jeff Postdoctoral Fellow; Scripps
1994-1999 Ph.D.
Xia, Xiaoyang Alanex Corporation
1992-1997 Ph.D. Part I: Stereocontrolled Synthesis of [beta]-2’-Deoxypyrimidine Nucleosides through Intramolecular Glycosylations; Part II: Minireceptor Enzyme Active Sites of HIV Protease
Guan, Ningning Doctoral Prog.; Biochemistry, Emory
1995-1997 M.S. University
Newer Methodologies for the Stereoselective Synthesis of 2’, 3’ – Dideoxynucleoside Analogues
Vo, Hoang Minh Part I: Novel Approaches Towards
1996-1998 M.S. the Synthesis of Hydroxyethylene Isosteres, a Class of HIV-Protease Inhibitors; Part II: Efficient and Stereoselective O-Glycosylation of 1-Acy-2-Sulfenyl-Dideoxy-Ribofuranoses Catalyzed by Cerium (III) Chloride
Cornett, Ben Eli Lilly
1997-2002 Ph.D. Solution Conformational Studies of
Microtubule-Stabilizing Agents
Curfman, Chris Patent Attorney, Needle and
1996-2000 Ph.D. Rosenberg, Georgia State School of Law
Synthetic Strategies Toward
Omega-Functionalized Sphingolipid Analogs
Byun, Kiyoung Faculty Fellow, Boston University
1997- 2001 Ph.D. Computational Studies Toward the
Design and Synthesis of Novel
Inhibitor Compounds
Ferstl, Eva Pharmacia, Milan, Italy,
1998-2000 Ph.D. Part I: Thiazolidine-2-Thione
Induced Diastereoselective Addition of Enolates to Imines. Part II: Novel Curcumin Analogs as Suppressors of Tumor Growth and Angiogenesis
Young, Josephine US Patent and Trademark Office,
1998-2000 Withdrew Washington, DC
Lakdawala, Ami Glaxo SmithKline
1999-2003 Ph.D. Part I. Structure & Dynamics of beta-Amyloid
Fibrils Part II. Design of Taxol (Paclitaxel) Analogs and Predictive Models; Design pf Measles Virus Inhibitors; Conformational Analysis of alpha-Helical Mimics
Ambhaikar, Narendra Postdoctoral Fellow, Scripps
1999-2003 Ph.D. Thiazolidine-2-thione Directed Diastereoselective
Additions of Chlorotitanium Enolates to Aldimine Derivatives
Leong, Lynette Pharmacopeia, Philadelphia
1999-2001 M.S.
Thepchatri , Pahk MLSCN, Emory University;
2000-2005 Ph.D. Identification of Conformational Ensembles in Solution: Potential Source of Bioactive Candidates
Pruett, Sarah Yerkes Regional Primate Center,
2000-2006 Ph.D. Emory.
Biological Mass Spectrometry of Sphingolipids in Drug Discovery and Development;
Mao, Shuli EIDD
2000-2005 Ph.D. Synthesis and Anti-HIV Activity of Novel
Cyclobutyl Nucleoside Analogs;
Herold, Marike Postdoctoral Fellow, Cambridge
2001-2005 Ph.D. University, UK
Diastereoselective One-Pot Synthesis of Azetines and b-Lactams Starting from Nitriles; Part II Novel Curcumin Analogs as Antitumor Agents
Itta Bluhn-Chertudi Scynexis, Research Triangle;
2001-2005 M.S. Methodology for the remote induction of asymmetric hydrocyation in a,b-unsaturated ketones
Dougherty, Ann Postdoctoral Fellow, Emory
2002-2007 Ph.D. University
Part 1. Synthesis Pyrrolidine Diol Sphongolipid Analogs and Evaluation of their Biological Activity Part 2. Synthesis of Pre-hemibrevetoxin B’ Polyene: Applications in the Biosynthesis of the Brevetoxins
Fang, Xingang Adjunct Professor, U. of West FL
2002-2008 Ph.D. Synthesis and Anti-Viral Activity
of Novel 3,6-dioxa-[3.2.0]bicyclonucleoside
Kurtkaya, Serdar System Analyst, MUSC
2002-2005 M.S. “3JC=CCH Karplus Equation And 3JFCCF Karplus Curve Derivation With The Help Of Computational Chemistry To Explain Unexpected NMR Coupling Data In Organic And Biological Systems & Structure-Activity Relationship Studies On Curcumin Analogs”
Moore, Rhonda Postdoctoral Fellow, U. of Colorado
2002-2006 Ph.D. Synthesis and Biological Evaluation of Novel
Phenyl Epothilone Analog and Oxazolidinone Directed Diastereoselective Synthesis of b-Amino Carbonyl Derivatives
Bluemling, Greg……………………………………… Principle Scientist, EIDD
2002-2010 Ph.D. Part I: Synthesis of Cyclobutyl
Nucleoside Analogs That Mimic AZT
for Inhibition of the K65R HIV-1
Reverse Transcriptase Mutant
Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation
Malick, Sanna………………………………………… Law School
2003-2006 M.S. Part 1. Synthesis of Curcumin Analogs and their Biological Evaluation on Microtubules and Actin in Prostate Cancer Cells
Part 2. Decomposition Studies of Curcumin Analog UBS 109 Using Mass Spectrometry
Part 3. Mass Spectrometry Study of CXCR4 Antagonist WZ40MS
McNevin, Chris………………………………………. Part 1. Stereoselective Synthesis of
2003-2008 Ph.D……….. Quaternary Center Bearing Azetines
………………. and B-Amino Acid Derivatives
………………. Part 2. Natural and
………………. Enantiomeric Progesterone
………………. Analogues for the
………………. Treatment of Traumatic Brain Injury
Yong Feng, (Lucy) Li………………………………. Part 1: Synthesis and Anti-HIV
2003-2008……………………………. Ph.D Activity of Novel Cyclobutyl
……………………………………………. Nucleoside and Nucleotide
Analogs
………………. Part 2: Synthesis of Fluorescent
………………. Nucleoside Analogs
………………. Part 3: Synthesis of Abacavir
Alcaraz, Ana…………………………. Computational Studies of Ligand-2003-2009 Ph.D. Protein Interactions Part I: The
……………………………………………. T-Taxol Conformation
……………………………………………. Part II: Elucidating Interdependent
……………………………………………. Binding Sites on Tubulin
……………….
Prussia, Andrew…………………………………….. ORISE Fellow, CDC
2003-2009 …. Ph.D.. Part I: Measles virus entry into cells and the
…………………………………………………………….. inhibition of fusion and replication Part II: The nature of cyclostreptin’s interaction with microtubules
Jogalekar, Ashutosh……………………………….. Molecular Modeler/Scientist,
2003-2009 …………………………… Ph.D. Ensemble Therapeutics
…………………………………………………………….. 1. Conformational Analysis of
…………………………………………………………….. Bioactive Molecules in Solution
…………………………………………………………….. 2. Design of Selective
…………………………………………………………….. Inhibitors for Cyclin-Dependent
…………………………………………………………….. Kinase 7
……………….
Geballe, Matt ………………. OpenEye Scientific
2003-2008 Ph.D……….. Part I: Structure and Function in the
………………. NMDA Ligand Binding Domain.
………………. Part II: Comparison of
………………. Paclitaxel Analogs through
………………. Molecular Dynamics Simulation;
………………. Solution Conformations
………………. of Cyclic Peptides.
Wright, Suzanne ………………. Withdrew
2003-2005
Zhan, Weiqiang ………………. Eli Lilly
2003-2008 Ph.D……….. Design, Synthesis and Biological
………………. Evaluation of C6-C8 Bridged
………………. Epothilone Analogs and Discovery of
………………. Small Molecule CXCR4
Becnel-Davis, Kimberlynne ………………. Associate at Kilpatrick, Townsend &
2003-2008 Ph.D……….. Stockton
………………. Synthesis of Cyclobutyl Nucleoside
………………. and.Nucleotide Analogues as HIV-1
………………. Reverse Transcriptase Inhibitors
……………….
Mosely, Cara ………………. Pabst Patent Group LLP
2004-2009 Ph.D……….. Design, Synthesis and Biological Evaluation of
………………. Subunit-Selective N-Methyl-D-Aspartate Receptor Antagonists Towards the Treatment of Neurodegenerative Diseases
……………….
Murray, Ernest ………………. Medical School
2004-2008 M. S………… College of Charleston
Neuman, Annette ……………………………………. Part I: Synthesis of 2′-Fluoro-2′,3′-
2004-2012 Ph.D. …………………………… Dideoxynucleosides asInhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase
Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV ReverseTranscriptase
Baillie, Mark ………………. Towards the Development of
2005-2011 Ph.D……….. Non-Toxic Therapeutics in the Fight
………………. Against Cancer
………………. Postdoctoral Fellow, Switzerland
Hu, Haipeng ………………. Validation of Receptor-Based Drug
2005-2011 Ph.D……….. Design and Applications in the Study of IKKs, Truncated Taxane and LRH-1
………………. Postdoctoral Fellow, Emory
Jiang, Yi ………………. Design, Synthesis and Biological
2005-2010 Ph.D……….. Evaluation of C4-C9 Bridged
………………. Epothilone Analogs
Kim, Mi-Sun Ph.D……….. Identification of modulators for the
2005-2012 ………………. SREB(Super Conserved Receptor Expressed in Brain) family
Purcell, Jamie ………………. Withdrew
2006-2007 ……………….
Truax, Valarie ………………. Design, Synthesis, and Biologic
2006-2014 Ph.D……….. Evaluation of Tetrahydroisoquinoline-based CXCR4 Modulators
……………….
Santangelo, Rose Chapter 1: Design and Synthesis of
2006-2012 Ph.D. GluN1/GluN2B Selective NMDA Receptor Antagonists for the Potential Treatment of Neurodegenerative Diseases; Chapter 2: Design, Synthesis, and Biological Evaluation of First-in-Class GluN2C/2D-Selective NMDA Receptor Potentiators
Zimmerman, Sommer Design, Synthesis, and Biological
2008-2013 Ph.D. Evaluation of Subunit-Selective N-Methyl- D-Aspartate Receptor Modulators
Shi, Qi Computer-Assisted Drug Discovery
2008-2014 Ph.D. Part I: Design, Development,
Validation and Application of
FRESH, a Novel In-Silico
High-throughput Screening Program
Part II: Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anticancer Properties
Part III: Development of 2nd Generation NAMFIS Software Program by Java
Acker, Tim ………………. Structural Determinants of Activity,
2008-2013 Ph.D. ……… Mechanism and Structure Activity Relationships of Novel GluN2C/D Subunit Selective Antagonists of the N-methyl-D-Aspartate Receptor
Miller, Eric Postdoc, Emory
2009-2015 Ph.D. Discovery of CF2-Enigmol, a
Fluorinated Enigmol
Ph.D.Analog with Enhanced Pharmacokinetic and Anti-Tumor Properties
……………….
Katzman, Brooke Postdoctoral Fellow, Mayo Clinic
2009-2014 Ph.D. Part 1: Design, Synthesis, and
Biological Evaluation of a Novel
Class of Allosteric Modulators of N–
Methyl-D-Aspartate Receptor
Function
Part 2: Discovery of Novel
Tetrahydroisoquinoline (THIQ)-
Based CXCR4 Antagonists and
Conformational Analysis of
Structurally Similar CXCR4 Antagonists
Strong, Katie ………………. Doctoral Program in Chemistry, 2009-present Ph.D. (projected) Emory
Baldwin, Patrick Postdoc, University of Maryland,
2010-2014 Ph.D. School of Medicine
Development of Monocarbonyl
Curcumin Analogues to Treat
Tuberculosis and Cancers
Giesler, Kyle ………………. Doctoral Program in Chemistry, 2012-present PhD (projected) Emory
Jing, Yao ………………. Doctoral Program in Chemistry, 2012-present PhD (projected) Emory
Prosser, Tony ………………. Doctoral Program in Chemistry, 2012-present PhD (projected) Emory
Jones, Matthew Doctoral Program in Chemistry, 2013-present Ph.D. (projected) Emory
Epplin, Matt Doctoral Program in Chemistry, 2014-present Ph.D. (projected) Emory
POSTDOCTORAL RESEARCH FELLOWS
Johnston, Judy (deceased) Dekalb College
1977-1978 Organoselenium Chemistry.
Saindane, Manohar Sterling-Winthrop
1980-1984 Organoselenium Chemistry,Diels-Alder Chemistry, Total Synthesis.
Hoekstra, William R. W. Johnson Pham. Res. Inst.
1987-1988 Synthesis of b-Lactamase Inhibitors.
Sunay, Ustun Consultant, Emory University
1987-1988, 2003-2011 Synthesis of Potential Anti-Leukemic Agents.
Tuberculosis
Yeola, Suresh Vanderbilt University
1987-1992 Synthesis of Potential Anti-Leukemic Agents.
Choi, Woo-Baeg F.O.B. Synthesis, Atlanta
1989-1991 Antiviral Synthesis
Soria, Jose Emory University, Lecturer
1990-1995 Synthesis of Potential Antiviral Agents
Hoong, Lee AtheroGenics, Inc.
1990-1995 Synthesis of Potential Antiviral Agents
Lagu, Bharat Synaptic Pharmaceutical
1991-1994 Corporation
Synthesis of Protein Kinase C Inhibitors
Nevins, Neysa Glaxo-SmithKline, Philadelphia
1994-1999 Molecular Modeling
Sisti, Nicholas SmithKline Beecham
1992-1993 Pharmaceuticals
Synthesis of Potential Antiviral Agents
El-Kattan, Yahya University of South Alabama
1992-1994 Synthesis of Chemical Sensitizers for Boron Neutron Capture Therapy
Wilson, Timothy Ciba-Geigy
1993-1995 Synthesis of Taxol Analogues
Wey, Shiowiyi NitroMed, Inc.
1993-1997 Synthesis of Antiviral Nucleosides
Alexander, Christopher College of Charleston
1993-1995 Sphingolipid analogue synthesis
Bushnev, Anatoliy Emory University
1995-present Sphingolipid analogue synthesis
Beall (Keffer), Jennifer New Jersey
1996-1999
Kasdorf, Krista Florida
1995-1997
Swiss, Kevin Connecticut
1996-1997
Venkatesan, Hari Johnson & Johnson, La Jolla, CA
1995-2000 Research Chemist
Zhang, Dawei Alanex Corporation
1996-1998
Martin Bouygues FOB Synthesis
1999-2002
Joubert, Muriel Returned to France
2001-2003
Sun, Aiming Emory University
2001-2005, 2011-2014 EIDD
Altas, Yesim Altiris
2000-2007
Yu, Xiaochun Returned to China
2003-2005
Saen-oon, Suwipa
2005-2006
Rheinecker, Jaime
2006-2007
Chris van der Westhuyzen
2008
Patrick Demana
2009
Pieter Burger
2009-2010, 2013-present
Michael Mckay
2010-2012
Stephen Pelly
2010-2011
Jason Holt
2008-2010
Terry Moore
2010-2013
Huanyu Zhao
2011-present
Bryan Cox
2012-2015
Alexandra Orchard
2012-2014
Gary Brandt
2012-2013
JJJJJJJJJJJJohn DiRaddo
Madhari Dasari
Michelle Kim
2015-present
ttrtrtrt
jyfjyt
Edgars Jec
2015-present
ttrtrtrt
Robert Wilson
2015-present
ttrtrtrt
Chris Butch
2015-present
Eric Miller
2015-present
PUBLICATIONS
- Katzman, B.; Perszyk, R.; Yuan, H.; Altas Tahirovic, Y.; Sotimehin, A.; Traynelis, S.; Liotta, D. A novel class of negative allosteric modulators of NMDA receptor function.Bioorg. Med. Chem. Lett., 2015, 25:5583-5588.
- Cox, B.; Mehta, A.; DiRaddo, J.; Liotta, D.; Wilson, L.; Snyder, J. Structural analysis of CXCR4 –Antagonist interactions using saturation-transfer double-difference NMR. Biochem and Biophysical Research Communications, 2015, http://dx.doi.org/10.1016/j.bbrc.2015.08.084.
- DiRaddo, J.; Miller, E.; Bowman-Dalley, C.; Wroblewska, B.; Javidnia, M.; Grajkowska, E.; Wolfe, B.; Liotta, D.; Wroblewski, J. Chloride is an agonist of group II and III metabotropic glutamate receptors. Mol Pharmacol , 2015 ,88:450-459.
- Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo by using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. J. Drug Targeting, 2015, 23(3): 257-265.
- Cox, B.; Prosser, A.; Sun, Y.; Li, Z.; Lee, S.; Huang, M.; Bond, V.; Snyder, J.; Krystal, M.; Wilson, L.; Liotta, D.Pyrazolo-Piperidines Exhibit Dual Inhibition ofCCR5/CXCR4 HIV Entry and Reverse Transcriptase. ACS Med. Chem. Lett.2015, 6: 753-757.
- Zhao, H.; Prosser, A.; Liotta, D.; Wilson, L. Discovery of novel N-aryl piperazine CXCR4 antagonists. Bioorg. & Med. Chem. Lett. 2015, in press.
- Yuan, H.; Myers, S.; Wells, G.; Nicholson, K.; Swanger, S.; Lyuboslavsky, P.; Tahirovic, Y.; Menaldino, D.; Ganesh, T.; Wilson, L.; Liotta, D.; Snyder, J.; Traynelis, S.Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects. Neuron., 2015, 85: 1305-1318.
- Baldwin, P.; Reeves, A.; Powell, K.; Napier, R.; Swimm, A.; Sun, A.; Giesler, K.; Bommarius, B.; Shinnick, T.; Snyder, J.; Liotta, D.; Kalman, D. Monocarbonyl analogs of curcumin inhibit growth of antibiotic sensitive and resistant strains of Mycobacterium tuberculosis.Eur. J. of Med. Chem., 2015, 92: 693-699.
- Khatri, A.; Burger, P.; Swanger, S.; Hansen, K.; Zimmerman, S.; Karakas, E.; Liotta, D.; Furukawa, H.; Snyder, J.; Traynelis, S. Structural Determinants and Mechanism of Action of GluN2C-selective NMDA Receptor Positive Allosteric Modulator.Mol. Pharmacol., 2014, 86:548–560.
- Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Liotta, D.; El-Rayes, B.; Brat, D.; Snyder, J.; Shoji, M. Tumor Angieogenesis Therapy Using Targeted Delivery of Pacclitaxel to the Vasculature of Breast Cancer Metastases.J. Drug Deliv., 2014.
- Zhu, S.; Kisiel, W.; Lu, Y.; Petersen, L.; Ndungu, J.; Moore, T.; Parker, E.; Sun, A.; Sarkaria, J.; Snyder, J.; Liotta, D.; Brat, D.; El-Rayes, B.; Shoji, M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody.J. Drug Target. 2014, 16:1-9.
- Strong, K.; Jing, Y.; Prosser, A.; Traynelis, S.; Liotta, D. NMDA receptor modulators: an updated patent review (2013-2014). Expert Opin. Ther. Patents.,2014, 24(12), 1349-1366.
- Zhou, T.; Ye, L.; Bai, Y.; Sun, A.; Cox, B.; Liu, D.; Li, Y.; Liotta, D.; Snyder, J.; Fu, H. Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: A novel curcumin analog. PLoS One., 2014,9 (9), e107876
- DiRaddo, J.; Miller, E.; Hathaway, H.; Grajkowska, E.; Wroblewska, B.; Wolfe, B.; Liotta, D.; Wroblewski, J. A Real-Time Method for Measuring cAMP Production Modulated by Gαi/o-Coupled Metabotropic Glutamate Receptors. J. Pharmacol.Exp. Ther., 2014, 349(3), 373–382.
- Hu, H.; Mao, S.; Bugrysheva, J.; Pruett, S.; Liotta, D.; Scott, J.; Snyder, J. Group A streptococcus inhibitors by high-throughput virtual screening.Eur. J. of Med. Chem., 2014, 82, 120-126.
- Cox, B.; Prosser, A.; Katzman, B.; Alcaraz, A.; Liotta, D.; Wilson, L.; Snyder, J. Anti-HIV Small Molecule Binding in the Peptide Subpocket of the CXCR4:CVX15 Crystal Structure.Chem. BioChem. 2014, 15(11), 1614-1620.
- Krumm S. A.; Yan, D.; Hovingh, E.; Evers, T. J.; Enkirch, T.; Prabhakar R.; Sun, A.; Manohar T.; Arrendale, R.; Painter, G.; Liotta, D.; Natchus, M.; von Messling, V.; Plemper, R. An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model. Sci. Transl. Med. 2014,6(232), p. 232ra52.
- Zimmerman, S.; Khatri, A.; Garnier-Amblard, E.; Mullasseril, P.; Kurtkaya, N.; Gyoneva, S.; Hansen, K.; Traynelis, S.; Liotta, D. Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators.J. Med. Chem. 2014, 57 (6), 2334-2356.
- Prosser, A.; Liotta, D. One-pot transformation of esters to analytically pure ketones: methodology and application in process development. Tet. Lett. 2014.Article in Press.
- Truax, V.; Zhao, H.; Katzman, B.; Prosser, A.; Alcaraz, A.; Saindane, Manohar T.; Howard, R.; Culver, D.; Arrendale, R.; Gruddanti, P., Taylor J.E., Natchus, M.; Snyder, J.; Liotta, D.; Wilson, L. Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists. ACS Med. Chem. Lett. 2013, 4(11), 1025- 1030.
- Acker,T.; Khatri, A.; Vance, K.; Slabber, C.; Bacsa, J.; Snyder, J.; Traynelis, S.; Liotta,
- Structure-Activity Relationships and Pharmacophore Model of a Noncompetitive Pyrazoline Page 39 Class of GluN2C/GluN2D Selective Antagonists. J. Med. Chem. 2013, 56(16), 6434- 6456.
- Moore, T.; Sana, K.; Yan, D.; Krumm, S.; Thepchatri,P.; Snyder, J.; Marengo, J.; Arrendale, R.; Prussia, A.; Natchus, M.; Liotta, D. Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy. ACS Med. Chem. Lett. 2013, 4(8), 762-767.
- Santangelo Freel, R.; Ogden, K.; Strong, K.; Khatri, A.; Chepiga, K.; Jensen, H.; Traynelis, S.; Liotta, D. Synthesis and Structure Activity Relationship of Tetrahydroisoquinoline-Based Potentiators of GluN2C and GluN2D Containing N-Methyl-D-aspartate Receptors. J. Med. Chem. 2013, 56(13), 5351-5381.
- Brown, A.; Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Snyder,
- Monocarbonyl Curcumin Analogues: Heterocyclic Pleiotropic Kinase Inhibitors That Mediate Anticancer Properties. J. Med. Chem. 2013, 56(9), 3456-3466.
- Moore, T.; Sana, K.; Yan, D.;Thepchatri, P.;Ndungu, J.;Sandaine, M.; Lockwood, M.; Natchus, M.; Liotta, D.;Plemper, R.; Snyder, J.; Sun, A. Asymmetric synthesis of host-directed inhibitors of myxovirus. Beilstein J. Org. Chem. 2013, 9(23), 197-203.
- Shi, Q.; Moore, T.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D.; Shim, H.; Brown, A.; Snyder,
- Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties. J. Med. Chem. 2013, 56 (9), 3456-3466.
- Kim, J.; Wang, L.; Li, Y.; Becnel, K.; Frey, K.; Garforth, S.; Prasad, V.; Schinazi, R.; Liotta, D.; Anderson, K. Pre-steady State Kinetic Analysis of Cyclobutyl derivatives of 2’-deoxyadenosine 5’-triphosphate as inhibitors of HIC-1 transcriptase. Bioorg. Med. Chem. Lett. 2012, 22(12), 4064-4067.
- Hassam, M.; Basson, A.; Liotta, D.; Morris, L.; van Otterlo, W.; Pelly, S. Novel Cyclopropyl- Indole Derivatives as HIV Non-Nucleoside Reverse Transctiptase Inhibitors. ACS Med. Chem. Lett. 2012, 3(6), 470-475.
- Guthrie, D.; Stein, D.; Liotta, D.; Lockwood, M.; Sayeed, I.; Atif, F.; Arrendale, R.; Reddy, P.; Evers, T.; Marengo, J.; Howard, R.; Culver, D.; Natchus, M. Water-Soluble Progesterone Analogues are Effective,Injectable Treatments in Animal Models of Traumatic Brain Injury. ACS Med. Chem. Lett., 2012, 3(5), 362-366.
- Burger, P.; Yuan, H.; Karakas, E.; Geballe, M.; Furkawa, H.; Liotta, D.; Snyder, J.; Traynelis,
- Mapping the binding of GluN2B-selectve N-methyl-D-aspartate receptor negative allosteric modulators. Mol. Pharmacol. 2012, 82(2), 344-359.
- Santangelo, R.; Acker, T.; Zimmerman, S.; Katzman, B.; Strong, K.; Traynelis, S.; Liotta,
- Novel NMDA Receptor Modulators: An Update. Expert Opin. Ther. Pat. 2012, 22(11), 1337- 1352.
- Meyer, E.; Holt,J.; Girard, K.; Baillie, M.; Bushnev, A.; Lapp, S.; Menaldino, D.; Arrendale, R.; Reddy, P.; Evers, T.; Liotta, D.; Galinski, M.; Natchus, M. Sphingolipid Analogues Inhibit Development of Malaria Parasites. ACS Med. Chem. Lett. 2012, 3(1),43-47.
- Liang, Z.; Zhan, W.; Zhu, A.; Yoon, Y.; Lin, S.; Sasakim Jan, M.; Klapproth, M.; Yang, H.; Grossniklaus, H.; Xu, J.; Yun, C.; Snyder, J.; Liotta, D.; Shim, H. Development of a Unique Small Molecule Modilator of CXCR4. PLoS one 2012, 7(4), e34038.
- Ndungu, J.; Krumm, S.; Yan, D.; Arrendale, R.; Reddy, P.; Evers, T.; Howard, R.; Natchus, M.; Sandaine, M.; Liotta, D.; Plemper, R.; Snyder, J.; Sun, A. Non-nuceoside Inhibitors of the Measles Virus RNA-dependent RNA Polymerase: Synthesis, Structure- Activity Relationships and Pharmacokinetics. J. Med. Chem. 2012, 55, 4220−4230.
- Olivera, A.; Moore, T.;Hua, F.; Brown, A.; Sun, A.; Liotta, D.; Snyder, J.; Yoon, Y.; Shim, H.; Marcus, A.; Miller, A.; Pace, T. Inhibition of the NF-signaling pathway by the curcumin analog, 3,5-Bis(,2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int. Immunopharmacol. 2012,12(2), 368-377.
- Boyle, G.; Edlin, C.; Li, Y.; Liotta, D.; Morgans, G.; Musondaa, C. Enantioselective Synthesis of the Carbocyclic Nucleoside (–)-Abacavir. Org. Biomol. Chem. 2012, 10(9), 1870-1876.
- Makarova, N.; Zhao, C.; Zhang, Y.; Bhosle, S.; Suppiah, S.; Rhea, J.; Kozyr, N.; Arnold, R.; Ly, H.; Molinaro, R.; Parslow, T.; Hunter, E.; Liotta, D.; Petros, J.; Blackwell, J. Antibody responses against xenotropic murine leukemia virus-related virus envelope in a murine model. PLoS one 2011, 6(4), e18272.
- Zhan, W.; Jiang, Y.; Sharma, S.; Brodie, P.; Bane, S.; Kingston, D.; Liotta, D.; Snyder, J. C6-C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle Chem. Eur. J. 2011, 17(52), 4792-14804.
- Wilson, L.; Liotta, D.Emergence of small-molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents. Drug Develop. Res. 2011, 72(7), 598-602.
- Symolon, H.; Bushnev, A.; Peng, Q.; Ramaraju, H.; Mays, S.; Allegood, J.; Pruett, S.; Sullards, M.; Dillehay, D.; Liotta, D., Merrill, A. Enigmol: A Novel Sphingolipid Analogue with Anticancer Activity against Cancer Cell Lines and In vivo Models for Intestinal and Prostate Cancer. Mol. Cancer Ther. 2011, 10(4), 648-657.
- Acker, T.; Yuan, H.; Hansen, K.; Vance, K.; Ogden, K.; Jensen, H.; Burger, P.; Mullasseril, P.; Snyder, J.; Liotta, D., Traynelis, S. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunitselective modulators. Mol. Pharmacol. 2011, 80(5), 782- 795.
- Garnier-Amblard, E.; Mays, S.; Arrendale, R.; Baillie, M.; Bushnev, A.; Culver, D.; Evers, T.; Holt, J.; Howard, R.; Liebeskind, L.; Menaldino, D.; Natchus, M.; Petros, J.; Ramaraju, H.; Reddy, P.; Liotta, D. Novel Synthesis and Biological Evaluation of Enigmols as Therapeutic Agents for Treating Prostate Cancer. ACS Med. Chem. Lett. 2011, 2(6), 438-443.
- Bushnev, A.; Baillie, M.; Holt, J.; Menaldino, D.; Merrill, A.; Liotta, D. An efficient asymmetric synthesis of enigmols (1-deoxy-5-hydroxysphingoid bases), an important class of bioactive lipid modulators. ARKIVOC (Gainesville, FL, United States) 2010, (8), 263-277.
- Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein. J. Phys. Chem. B (2010), 114(2), 1127-1135.
- Zhu, A.; Zhan, W.; Liang, Z.; Yoon,Y.; Yang, H.; Grossniklaus, H.; Xu, J.; Rojas, M.; Lockwood, M.; Snyder, J.; Liotta, D.; Shim, H. Dipyrimidine Amines: A Novel Class of Chemokine Receptor Type 4 Antagonists with High Specificity. J. Med. Chem. 2010, 53 (24), 8556-8568.
- Heathcote, D.; Petal, H.; Kroll, S.; Hazel, P.; Periyasamy, M.; Alikian, M.; Kanneganyi, S.; Jogalekar, A.; Scheiper, B.; Bräckow, J.; Siwicka, A.; Pace, R.; Fuchter, M.; Snyder, J.; Liotta, D.; Freemont, P.; Aboagye, E.; Coombes, R.; Barrett, A.; Ali, S. A novel pyrazolo[1,5- a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2 and 9, which demonstrates anti-tumour effects in human tumour xenografts following oral administration. J.Med. Chem. 2010, 53 (24), 8508-8522.
- Thomas, S.; Zhao, J.; Li, Z.; Lou, B.; Du, Y.; Purcell, J.; Snyder, J.; Khuri, F.; Liotta, D.; Fu,
- Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem. Pharmacol., 2010, 80 (9), 1309-1316.
- Xin, T.; Sidell, N.; Mancini, A.; Huang, R.; Wang, S.; Horowitz , I.; Liotta, D.; Taylor, R.; Friedrich, W. Multiple Anticancer Activities of EF24, a Novel Curcumin Analog, on Human Ovarian Carcinoma Cells. Reprod. Sci. 2010, 17 (10), 931-40.
- Mullasseril, P.; Hansen, K.; Vance, K.; Ogden, K.; Yuan, H.; Kyrtkaya, N.; Santangelo, R.; Orr, A.; Le, P.; Vellano, K.; Liotta, D.; Traynelis, S. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat.Commun. 2010, 1 (90).
- Suppiah, S.; Sun, C.; Zhang, X.; Bhosle, S.; Rhea, J.; Mays, S.; Parslow, T.; Arnold, R.; Makarova, N.; Liotta, D.; Hunter, E.; Blackwell, J.;Petros, J.; Ly, H.; Molinaro, R. A Novel Transforming Gene Product of the Xenotropic Murine Leukemia Virus-Related Virus. Submitted.
- Arnold, R.; Makariva, N.; Osunkoya, A.; Suppiah, S.; Scott, T.; Johnson, N.; Bhosle, S.; Liotta, D.; Hunter, E.; Marshall, F. XMRV infection in patients with prostate cancer; novel serologic assay and correlation with PCR and FISH. J Urol. 2010, 75(4), 755-61.
- Pandey, K.; Snyder, J.; Liotta, D.; Musaev, D. Computational Studies of Transition Metal Selectivity of Octapeptide Repeat Region of Prion Protein (PrP). J. Phys. Chem. B. 2010, 114(2), 1127-1135.
- Li, Y.; Soni, P., Liotta, D.; Liu, L.; Zhang, X.; Lutz, S. Synthesis of fluorescent nucleoside analogs as probes for 2’-deoxyribonucleoside kinases. Bioorg. Med. Chem. Lett. 2010, 20(3), 841-843.
- Sun, A.; Lu, Y.; Hu, H.; Shoji, M.; Liotta, D.; Snyder, J. Curcumin analog cytotoxicity against breast cancer cells: Exploitation of a redox-dependent mechanism. Bioorg. Med. Chem. Lett. 2009, 19 (23), 6627-6631.
- Bhosle, S.; Suppiah, S.; Molinaro, R.; Liang, Y.; Arnold, R.; Petros, J.; Diehl, W.; Makarova, N.; Blackwell, J.; Petros, J.; Liotta, D.;Hunter, E.; Ly, H. Evaluation of cellular determinants required in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells. J. Virol. 2010, 84(13), 6288-96.
- Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting. Nucleic Acids Res. 2009, 37(13), 4472-4481.
- Mosley, C.; Wilson, L.; Wiseman, J.; Skudlarek, Liotta, D.; Jason, W. Recent patents regarding the discovery of small molecule CXCR4 antagonists. Expert Opin. Ther. Patents 2009, 19(1), 23-28.
- Ali, S.; Heathcote, D.; Kroll, S.; Jogalekar, A.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.; Periyasamy, M.; Tolhurst, R.; Kanneganti, S.; Snyder, J.; Liotta, D.; Aboagye, E.; Barrett, A.; Coombes, R. The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity. Cancer Res. 2009, 69(15), 6208-6215.
- Mosley, C.; Myers, S.; Murray, E.; Santangelo, R.; Tahirovix, Y.; Kurtkaya, N.; Mullasseril, P.; Yuan, H.; Lyuboslavsky, P.; Le, P. Wilson, L.; Yepes, M.; Dingledine, R.; Traynelis, S.; Liotta, D. Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic Med. Chem. 2009, 17(17), 6463-6480.
- MacNevin, C.; Atif, F.; Sayeed, I.; Stein, D.; Liotta, D. Development and Screening of Water- Soluble Analogues of Progesterone and Allopregnanolone in Models of Brain Injury. J. Med. Chem. 2009, 52(19), 6012-6023.
- Kasinski, A.; Du, Y.; Thomas, S.; Zhao, J.; Sun, S.; Khuri, F.; Wang, C.; Shoji M., Sun, A.; Snyder, J.; Liotta, D.; Fu, H. Inhibition of IKB Kinase-Nuclear Factor-KB Signaling Pathway by 3,5-Bis-(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin. Mol. Pharmacol. 2009, 74 (3), 654-661.
- Thomas, S.; Zhong, D.; Zhou, W.; Malik, S.; Liotta, D.; Snyder, J.; Hamel, E.; Giannakakou,
- EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF- 1. Cell Cycle 2008, 7:1, 2409-2417.
- Thepchatri, P.; Min, J.; Ganesh, T.; Du, Y.; Lewis, I.; Kurtkaya, S.; Prussia, A.; Li, L.; Plemper, R.; Fu, H.; Liotta, D.; Snyder, J.; Dingledine, R. Cancer and Virus Leads by HTS, Chemical Design and SEA Data Mining. Curr. Med. Chem. 2009, 9 (13), 1159-1171.
- Pruett, ; Bushnev, A.; Hagedorn, K.; Adiga, M.; Haynes, C.; Sullards, M.; Liotta, D.; Merrill, A Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols. J. Lipid Res. 2008, 49: 1621-39.
- Liu, L.; Li, Y.; Liotta, D.; Lutz, S. Directed evolution of an orthogonal nucleoside analog kinase via fluorescence activated cell sorting. Nucleic Acids Res. 2009, 1-10.
- Tahirovic, Y.; Geballe, M.; Gruszecka-Kowalik, E.; Myers, S.; Lyuboslavsky, P.; Le, P.; French, A.; Irier, H.; Choi, W.; Easterling, K.; Yuan, H.; Wilson, L.; McNamara, J.; Dingledine, R.; Liotta, D.; Traynelis, S.; Snyder, J. Enantiomeric propanolamines as selective N-methyl-Daspartate 2B receptor antagonists. J. Med.Chem. 2008, 51(18), 5506-5521
- Shoji, M.; Sun, A.; Kisiel, W.; Lu,Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.), Journal of Drug Targeting, 2008 16:3, 185-197.
- MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and Their β-Amino Acid Derivatives. J. Org. Chem. 2008, 73(4), 1264-1269.
- Zhan, W.; Jiang, Z.; Brodie, P.; Kingston, D.; Liotta, D.; Snyder, J. Design and Synthesis of C6- C8 Bridged Epothilone A. Org. Lett. 2008, 10(8), 1565-1568.
- Shoji, M.; Sun, A.; Kisiel, W.; Lu, Y.; Shim, H.; McCarey, B.; Nichols, C.; Parker, E.; Pohl, J.; Mosley, C.; Alizadeh, A.; Liotta, D.; Snyder, J. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. Journal of Drug Targeting 2008, 16(3), 185-197.
- MacNevin, C.; Moore, R.; Liotta, D. Stereoselective Synthesis of Quaternary Center Bearing Azetines and their B-amino Acid Derivatives. J. Org. Chem. 2008, 73, 1264-69.
- Zhan, W.; Liang, Z.; Zhu, A.; Kurtkaya, S.; Shim, H.; Snyder, J.; Liotta, D. Discovery of Small Molecule CXCR4 Antagonists. J. Med. Chem. 2007, 50(23), 5655-5664.
- Li, Y.; Mao, S.; Hager, M.; Becnel-Davis, K.; Schinazi, R.; Liotta, D. Synthesis and Evaluation of 2′-Substituted Cyclobutyl Nucleosides and Nucleotides as Potential Anti-HIV Agents. Biooorg. Med. Chem. Lett. 2007,17(12), 3398-3401.
- Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as new anticancer principles: an efficient procedure for stereoselective syntheses of 2-amino-3,5-diols. Org. Lett. 2007, 9(15), 2959.
- Mosley, C.; Liotta, D.; Snyder, J.; Aggarwal, B.; Surh, B.; Shishoda, Y.; Eds, S. Highly Active Anti-Cancer Curcumin Analogs. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease 2007, Vol. 595, pp. 77-103.
- Herold-Dublin, M.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolates of N-Acyl Thiazolidinethione to Activated Imines: A Novel Synthesis of β-Lactams. Can. J. Chem. 2006, 84(12), 1696-1699.
- Sun, A.; Prussia, A.; Zhan, W.; Murray, E.; Doyle, J.; Cheng, L.; Yoon, J.; Radchenko, E.; Palyulin, V.; Compans, R.; Liotta, D.; Plemper, R.; Snyder, J. Nonpeptide Inhibitors of Measles Virus Entry. J. Med. Chem. 2006, 49(17), 5080-5092.
- Sun, A.; Shoji, M.; Lu, Y.; Yang, J.; Liotta, D.; Snyder, J. Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. J. Med. Chem. 2006, 49(11), 3153-8.
- Dougherty, A.; McDonald, F.; Liotta, D.; Moody, S.; Pallas, D.; Pack, C.; Merrill, A. Synthesis of 1-Deoxysphingsine Derivatives with Conformationally Restricted Pyrrolidinediol Head Groups. Org. Lett. 2006, 8(4), 649-52.
- Doyle, J.; Prussia, A.; White, L.; Liotta, D.; Snyder, J.; Compans, R.; Plemper, R. Two Domains that Control Prefusion Stability and Transport Competence of the Measles Virus Fusion Protein. J. Virol. 2006, 80(3), 1524-36.
- Wiseman, J.; McDonald, F.; Liotta, D. 1-Deoxy-5-hydroxysphingolipids as New Anticancer Principles: An Efficient Procedure for Stereoselective Syntheses of 2-Amino-3,5-diols. Org. Lett. 2005, 7(15), 3155-3157.
- Plemper, R.; Doyle, J.; Sun, A.; Prussia, A.; Cheng, L.; Rota, P.; Liotta, D.; Snyder, J.; Compans, R. Design of a Small Molecule Entry Inhibitor with Activity Against Primary Measles Virus Strains. Antimicrob. Agents Chemother. 2005, 49, 3755-3761.
- Adams, B.; Cai, J.; Armstrong, J.; Herold, M.; Lu, Y.; Sun, A.; Snyder, J.; Liotta, D.; Jones, D.; Shoji, M. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism. Anti-Cancer Drugs 2005, 16(3), 263-275.
- Hernandez-Santiago, B.; Chen, H.; Asif, G.; Mao, S.; Beltran, T.; Hurwitz, S.; Grier, J.; McClure, H.; Chu, C.; Liotta, D.; Schinazi, R. Pharmacology and Pharmacokinetics of the Antiviral Agent ß-D-2′,3′-Dideoxy-3′-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys. Antimicrob. Agents Chemother. 2005, 49 (7), 2589-2597.
- Adams, B.; Ferstl, E.; Davis, M.; Herold, M.; Kurtkaya, S.; Camalier, R.; Hollingshead, M.; Kaur, G.; Sausville, E.; Rickles, F.; Snyder, J.; Liotta, D.; Shoji, M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg. Med. Chem. 2004, 12(14), 3871-3883.
- Ambhaikar, N.; Liotta, D.; Herold, M. A Uniquely Accessible Route to the Diastereoselective Synthesis of Azetine Derivatives, Heterocycles, 2004, 62, 217-222.
- Plemper, R.; Erlandson, K.; Lakdawala, A.; Sun, A.; Prussia, A.; Boonsombat, J.; Aki-Sener, E.; Yalcin, I.; Yildiz, I.; Temiz-Arpaci, O.; Tekiner, B.; Liotta, D.; Snyder, J.; Compans, J. A Target Site for Template-base Design of Measles Virus Entry Inhibitors. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 5628-5633.
- Painter, G.; Almond, M.; Mao, S.; Liotta, D. Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase. Curr. Med. Chem. 2004, 4(10), 1035-1044.
- Mao, S.; Bouygues, M.; Welch, C.; Biba, M.; Chilenski, J.; Schinazi, R.; Liotta, D. The Synthesis and Anti-HIV Activity of Enantiomerically Pure D-FDOC. Bioorg. Med. Chem. Lett. 2004, 14, 4991-4994.
- Menaldino, D.; Bushnev, A.; Sun, A.; Liotta, D.; Symolon, H.; Desai, K.; Dillehay, D.; Peng, Q.; Wang, E.; Allegood, J.; Trotman-Pruett, S.; Sullards, M.; Merrill, A. Sphingoid bases and de novo ceramide synthesis: Enzymes involed, pharmacology and mechinisma of activation/regulation, Pharm. Res. 2003, 47 (5), 373-381.
- Guindon, Y.; Ogilvie, W.;Bordeleau, J.; Cui, W.; Durkin, K.; Gorys, V.; Juteau, H.; Lemieux, R.; Liotta, D.; Simoneau, B.; Yoakim, C. Opening of Tartrate Acetals Using Dialkylboron Bromide. Evidence for Stereoselectivity Downstream from Ring Fission, J. Amer. Chem. Soc. 2003,125(2), 428-436.
- Painter,G.; Rimsky, L.; Furman, P.; Liotta, D.; Schinazi, R.; Quinn, J. Preclinical and Clinical Development of the anti-HIV, anti-HBV Oxathiolane Nucleoside Analog Emtricitabine. Front. Vir. Hep.2003, 451-484.
- Ambhaikar, N.; Snyder, J.; Liotta, D. Diastereoselective Addition of Chlorotitanium Enolate of N-Acyl Thiazolidinethione to O-Methyl Oximes: A Novel, Stereoselective Synthesis of α,β- Disubstituted β-Amino Carbonyl Compounds via Chiral Auxiliary Mediated Azetine Formation. J. Am. Chem. Soc. 2003, 125 (3), 3690-3691.
- Merrill, A., Sullards, M.; Allegood, J.; Wang, E.; Linn, S.; Andras, L.; Liotta, D.; Hartl, M.; Humpf,
- Insights into the modulation of ceramide metabolism by naturally occurring and synthetic sphingolipid analogs as monitored by electrospray tandem mass spectrometry, “Ceramide Signaling” (A. H.Futerman, ed., Landes Bioscience Pub.), ISBN: 0-306-47442-5, 2002.
- Lakdawala, A.; Morgan, D.; Liotta, D.; Lynn, D.; Snyder, J. Dynamics and Fluidity of Amyloid: A Model of Fibrous Protein Aggregates, J. Am. Chem. Soc. 2002, 124 (51),15150-15151.
- Morgan, D.; Lynn, D.; Lakdawala, A.; Liotta, D.; Snyder, J. Amyloid structure: models and theoretical considerations in fibrous aggregates. J. Chin. Chem. Soc. (Taipei, Taiwan) 2002, 49 (4), 459-466.
- Ferstl, E.; Venkatesan, H.; Ambhaikar, N.; Snyder, J.; Liotta, D. Thiazolidine-2-thione directed diastereoselective addition of chlorotitanium enolates to aldimines. Synthesis 2002, (14), 2075- 2083.
- Painter, G.; Anderson, K.; Bouygues, M.; Joubert, M.; Liotta, D.Virally Encoded Polymerases as Targets for Chemotherapy: Application to HIV and HBV. Curr. Med. Chem.: Anti-Infective Agents 2002, 1 (2), 99-117.
- Schinazi, R.; Mellors, J.; Bazmil, H.; Diamond, S.; Garber, S.; Gallagher, K.; Geleziunas, R.; Klabe, R.; Pierce, M.; Rayner, M.; Wu, J.; Zhang, H.; Hammond, J.; Bacheler, L.; Manion, D.; Otto, M.; Stuyver, L.; Trainor, G.; Liotta, D.; Erikson-Viitanen, S. DPC 817: a Cytidine nucleoside analog with activity against zidovudine- and lamivudine-resistant viral variants. Antimicrob. Agents Chemother. 2002, 46 (5), 1394-1401.
- Desai, K.; Sullards, M.; Allegood, J.; Schmelz, E.; Hartl, M.; Humpf, H.; Liotta, D.; Peng, Q.; Merrill, A. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis(Apoptosis induced by sphingoid bases). Biochem. Biophys. Acta special issue 2002, 1585 (2-3), 188-192.
- Nicolaou, K.; Namato, K.; Ritzen, A.; Ulven, T.; Shoji, M.; Li, J.; D’Amico, G.; Liotta, D.; Altmann, K.; Giannakakou, P. Chemical Synthesis and Biological Evaluation of cis- and trans- 12, 13-Cyclopropyl and 12,13-Cyclobutyl Epothilones and Related Pyridine Side Chain Analogues. J. Am. Chem. Soc. 2001, 123(38), 9313-9323.
- Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Shi, J.; Liotta, D.; Coderre, J.; Olson,
- Preclinical Development of β-D-5-o-Carboranyl-2’-Deoxyuridine (D-CDU) for the Treatment of Malignant Brain Tumors. Frontiers in Neutron Capture Therapy (Hawthorne et al.,Ed.) 2001, 2, 1121-1124.
- Lakdawala, A.; Wang, M.; Nevins, N.; Liotta, D.; Roszak, D.; Lozynski, M.; Snyder,
- Calculated Conformer Energies for Organic Molecules with Multiple Polar Functionalities are Method Dependent: Taxol (Case Study). BMC Chemical Biology 2001, 1:2 .
- Hill, C.; Judd, D.; Nettles,J.; Nevins, N.; Schinazi, R.; Snyder, J.; Liotta, D.; Tang,
- Polyoxometalate HIV-1 Protease Inhibitors. Modeling Polyoxometalate-Enzyme Interactions. J. Am. Chem. Soc. 2001, 123, 886-897.
- Venkatesan, H.; Davis, M.; Snyder, J.; Liotta, D. Total Synthesis of SR 121463 A, a Highly Potent and Selective Vasopressin V2 Receptor Antagonist. J. Org. Chem. 2001, 66, (11), 3653- 3661.
- Wang, M.; Cornett,B.; Nettles, J.; Liotta, D.; Snyder, J. The Oxetane Ring in Taxol. J. Org. Chem. 2000, 65, 1059-1068.
- Schinazi, R.; Hurwitz, S.; Liberman, I.; Juodawlkis, A.; Tharnish, P.; Shi, J.; Liotta, D.; Coderre, J.; Olson, J. Treatment of Isografted 9L Rat Brain Tumors with β-5-ο-Carboranyl-2’- Deoxyuridinr Neutron Capture Therapy. Clin. Cancer Res. 2000, 6, 725-730.
- Curfman, C.; Liotta, D. Synthesis of Sphingosine and Sphingoid Bases. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling, 2000, 311, 391-440. (Merrill, A.; Hannun, Y. Eds.).
- Bushnev, A.; Liotta, D. Practical Synthesis of N-palmitoylsphingomyelin and N- palmitoyldihydrosphingomyelin. Methods Enzymol.: Sphingolipid Metabolism and Cell Signaling (A. H. Merrill and Y. A. Hannun, Eds.), 2000, 311, 535-546.
- Wang, M.; Xia, D.; Schestopol, M.; Kim, Y.; Hwang, D.; Jansen, J.; Botta, M.; Liotta, D.; Snyder,
- A Unified and Quantitative Receptor Model for the Microtubule Binding of Taxol and Epothilone. Org. Lett. 1999, 1, 43-46.
- Schmelz, E.; Bushnev, A.; Dillehay, D.; Sullards, M.; Liotta, D.; Merrill, A. Ceramide β-D- glucuronide: Synthesis, digestion and suppression of early biomarkers of colon carcinogenesis. Cancer Res. 1999, 59, 5768-5772.
- Warden, L.; Menaldino, D.; Wilson, T.; Liotta, D.; Smith, E.; Merrill, A. Identification of ammonium ion and 2,6-bis-(ω-aminobutyl)-3,5-diimino-piperazine as endogenous factors that account for the burst of sphingosine upon changing the medium of J774 cells in culture. J. Biol. Chem. 1999, 48, 33875-33880.
- Ma, L.; Hurwutz, S.; Shi, J.; McAtee, J.; Liotta, D.; McClure, H.; Schinazi, R. Pharmacokinetics of the Antiviral Agent ß-D-2’,3’-Didehydro-2’,-3’-Dideoxy-5-Fluorocytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1999, 43(2), 381-384.
- Shi, J.; McAtee, J.; Schlueter-Wirtz, S.; Tharnish, P.; Juodawlkis, A.; Liotta, D.; Schinazi,
- Synthesis and Biological Evaluation of 2’,3’-Didehydro-2’,3’-dideoxy-5-fluorocytidine (D4FC) Analogs: Discovery of Carbocyclic Nucleoside Triphosphates with Potent Inhibitory Activity Against HIV-1 Reverse Transcriptase. J. Med. Chem. 1999, 42, 859-867.
- Schinazi, R.; McAtee, J.; Liotta, D. A Completely Diastereoselective Electrophilic Fluorination of a Chiral, Non-carbohydrate Sugar Ring Precursor: Application to the Synthesis of Several Novel 2’-Fluoro Nucleosides. J. Org. Chem. 1998, 63, 2161-2167.
- Birt, D.; Merrill, A.; Barnett, T.; Enkvetchakul, B.; Pour, P.; Liotta, D.; Geisler, V.; Menaldino, D.; Schwartzbauer, J. Inhibition of Skin Carcinomas but not Papillomas by Sphingosine, N- methylsphingosine, and N-acetyl Sphingosine. Nutr & Cancer, 1998, 31, 119-126.
- Humpf, ; Schmelz, E.; Meredith, F.; Vesper, H.; Vales, T.; Menaldino, D.; Liotta, D.; Merrill, Acylation of Naturally Occurring and Synthetic 1-Deoxysphinganines by Ceramide Synthase: Formationof N-Palmitoyl-aminopentol (PAP1) Produces a Toxic Metabolite of Hydrolyzed Fumonisin (AP1). J. Biol. Chem. 1998, 30, 19060-19064.
- Snyder, J.; Xia, X.; Schestopol, M.; Kim, Y.; Bray, D.; Cain, M.; Liotta, D.; Koehler, K.; Jansen, Minireceptors for Molecular Design, in “Rational Molecular Design in Drug Research,” (T. Liljefors, F.S.Jorgenson, and P. Krogsgaard-Larsen, Eds., Munksgaard, Copenhagen). 1998, 115-135.
- Schinzai, R.; McMillan, A.; Lloyd, R.; Schuleter-Wirtz, S.; Liotta, D.; Chu, C. Molecular Properties of HIV-1 Resistant to (+) and (–)-Enantiomers and Racemates of Oxathlolane Cytosine Nucleosides and their Potential for the Treatment of HIV and HBV Infections. Antiviral Res. 1997, 34 (2).
- Nikolova-Karakashian, M.; Morgan, E.; Alexander, C.; Liotta, D.; Merrill, A. Bimodal Regulation of Ceramidase by Interleukin-1b: Implications for the Regulation of Cytochrome P450 2C11 (CYP2C11). J. Biol. Chem. 1997, 272, 18718-18724.
- X. Xia, J. Wang, M. W. Hager, N. Sisti and D. Liotta. Stereocontrolled Synthesis of β-2’- Deoxypyrimidime Nucleosides via Intramolecular Glycosylations. Tetrahedron Lett. 1997, 38, 1111-1112.
- Schmelz, E.; Bushnev, A.; Dillehay, D.; Liotta, D.; Merrill, A. Suppression of Aberrant Colonic Crypt Foci by Synthetic Sphingomyelina with Either Saturated of Unsaturated Sphingoid Base Backbones. Nutr. & Cancer 1997, 28, 81-85.
- Kikolova-Karakashian, M.; Vales, T.; Wang, E.; Menaldino, D.; Alexander, C.; Goh, J.; Merrill, A.; Liotta, D. Ceramide Synthase and Ceramidases in the Regulation of Sphingolipid Base Metabolism. Sphingolipidmediated Signal Transduction. Molecular Biology Intelligence Unit, (Hannun Y. A., Ed.) 1997, 159-172.
- Goudgaon, N.; El-Kattan, Y.; Xia, X.; McAtee, J.; Soria, J.; Wey, S.; Liotta, D.; Schinazi, R. A General Synthetic Method of 5-Carboranyluracil Nucleosides with Potential Antiviral Activity and Use in Neutron Capture Therapy, Nucleosides and Nucleotides 1997, 16, 2133-2150.
- Merrill, A.; Liotta, D.; Riley, R. Fumonisins: Fungal Toxins that Shed Light on Sphingolipid Function. Trends Cell Biol. 1996, 6, 218.
- Alexander, C.; Liotta, D. A Diastereoselective Synthesis of (2S, 3R, 4S)-Amino-1-cyclohexyl-6- methylheptane-3,4-diol, the Abbott Aminodiol. Tetrahedron Lett. 1996, 12, 1961.
- Captain, L.; Xia; Xiaoyang; Liotta, D. Remote Asymmetric Induction in Organocopper Conjugate Additions to 3-Ketoacrylates. Tetrahedron Lett. 1996, 37 (25), 4293.
- Merrill, A.; Liotta, D.; Riley, R. Bioactive Properties of Sphingosine and Structurally Related Compounds. Handbook of Lipid Research, Lipid Second Messengers 1996, 8, 205.
- Merrill, A.; Liotta, D.; Riley, R. Sphingolipid Analog Biomodulators in Foods Alter Sphingolipid Metabolism. Implications for Health and Disease. Proc. Nutri. Soc. Australia, 1996, 20, 124.
- Merrill, Jr., A.; Liotta, D.; Riley, R. Sphingolipids as Regulators of Cellular Growth, Differentiation, and Behavior. Adv. Lipobiology, 1996, 1, 273.
- Merrill, A.; Wang, E.; Vales, T.; Smith, E.; Schroeder, J.; Menaldino, D.; Alexander, C.; Crane, H.; Xia, J.; Liotta, D.; Meredith, R.; Riley, R. Fumonisin Toxicity and Sphingolipid Biosynthesis. Proceedings of the ACS Symposium on Fumonisins in Food (April 2-7, 1995, Anaheim, CA), Adv. Exp. Med. Biol. 1996, 392, 297.
- Liotta, D.; Jones, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. Adv. Mol. Modeling 1995, 3, 1-19.
- Wilson, L.; Hager, M.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleosides Bases with Furanoside Sugars. Synthesis, 1995, 1465.
- Jones, D.; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Adv. Mol. Modeling 1995, 3, 67-98.
- Choi, W.; Churchill, H.; Lynch, J.; Volante, R.; Reider, P.; Shinkai, I.; Jones, D.; Liotta, D. An Unusual Stereoselective Decarboxylation: A Key Reaction in the Synthesis of an Important Intermediate for Carbapenem Antibiotics. J. Org. Chem. 1995, 60, 8367.
- Xie, H.; Voronkov, M.; Liotta, D.; Korba, B.; Schinazi, R.; Richman, D.; Hostetler, Phosphatidyl-2′,3′-Thiacytidine: Synthesis and Antiviral Activity, in Hepatitis B and HIV-1 Infected Cells. Antiviral Res. 1995, 28, 113.
- Wilson, L.; Hager, M.; El-Kattan, Y.; Liotta, D. Nitrogen Glycosylation Reactions Involving Pyrimidine and Purine Nucleoside Bases With Furanoside Sugars. Synthesis 1995, 12, 1465- 79.
- Hoekstra, W.; Bonner, M.; Andrade-Gordon, P.; Evangelisto, M.; Keane, P.; Press, J.; Tomko, K.; Fan, F.; Kloczewiak, M.; Mayo, K.; Durkin, K.; Liotta, D. Design and Evaluation of Non- peptide Fibrinogen Gamma Chain Based GPIIB/IIIA Antagonists. J. Med.Chem. 1995, 38, 1582.
- Chao, R.; Bielawska, A.; Pushkareva, M.; Crane, H.; Lagu, B.; Merrill, A.; Liotta, D.; Hannun,
- Stereoselectivity of Induction of Rb Dephsophorylation by D-erythro-sphingosine Implicated Rb in Growth Suppression by Sphingosine. Biochem. 1995, 34, 1885.
- V.Dirsch, J. Frederico, N. Zhao, G. Cai, Y. Chen, S. Vunnam, J. Odingo, H. Pu, K. Nakanishi,
- Berova, D. Liotta, A. Bielawska and Y. Hannun. A Two-Step Chemical and Circular Dichroic Method for Assigning the Absolute Configurations of Sphingosines. Tetrahedron Lett. 1995, 36, 4959.
- Schroeder, J.; Crane, H.; Xia, J.; Merrill, A.; Liotta, D. Disruption of Sphingolipid Metabolism and Stimulation of DNA Synthesis by Fumonisin B1. A Molecular Mechanism for Carcinogenes Associated with Fursarium moniliforme. J. Biol. Chem., 1994, 269, 3475.
- Lagu, B.; Liotta, D. Diastereoselective Synthesis of the Key Lactone Intermediate for the Preparation of Hydroxyethylene Dipeptide Isosteres. Tetrahedron Lett. 1994, 35(4), 547-50.
- Goh, J.; Lagu, B.; Wurster, J.; Liotta, D. Aldol Reactions of a-(N,N-Dibenzylamino) Ethyl Ketones. Tetrahedron Lett. 1994, 35(33), 6029-32.
- Jones, D.; Liotta, D.; Choi, W.; Volante, R.; Reider, P.; Shinkai, I.; Churchill, H.; Lynch, J. A Facially-Selective Protonation Controls the Stereochemistry of a Key Intermediate in the Synthesis of 1b-Methylcarbapenems. J. Org. Chem. 1994, 59(14), 3749-51.
- Jarugula, V.; Schinazi, R.; Fulcrand, G.; El Kattan, Y.; Boudinot, F.; Liotta, D. Pharmacokinetics of 5-Carboranyl-2’-Deoxyuridine in Rats. J. Pharm. Sci. 1994, 83(12), 1697-9.
- Schinazi, R.; Gosselin, G.; Faraj, A.; Korba, B.; Liotta, D.; Chu, C.; Mathe, C.; Imbach, J.; Sommadossi, J. Pure Nucleoside Enantiomers of b-2′,3′-Dideoxycytidine Analogues are Selective Inhibitors of Hepatitis B Virus and Human Immunodeficiency Virus in Vitro. Antimicrob. Agents Chemother. 1994, 38(9), 2172-4.
- Hoekstra, W.; Press, J.; Bonner, M.; Andrade-Gordon, P.; Keane, P.; Durkin, K.; Liotta, D.; Mayo, K. Adamantane and Nipecotic Acid Derivatives as Novel b-Turn Mimics. Bio. Med. Chem. Lett. 1994, 4(11), 1361-4.
- Schinazi, R.; Goudgaon, N.; Fulcrand, G.; El-Kattan, Y.; Lesnikowski, Z.; Moravek, J.; Liotta,
- Cellular Pharmacology and Biological Activity of 5-Carboranyl-2’-Deoxyuridine. Intl. J. Radiation Oncol. Int. J. Radiation Oncology Biol. Phys. 1994, 28(5), 1113-20.
- Abobo, C.; Ni, L.; Schinazi, R.; Liotta, D.; Boudinot, F. Pharmacokinetics of 2′,3′-Dideoxy-5- fluoro-3′-thiacytidine in Rats. J. Pharm. Sci. 1994, 83(1), 96-9.
- Guindon, Y.; Yoakim, C.; Gorys, V.; Ogilvie, W.; Delorme, D.; Renaud, J.; Robinson, G.; Lavallee, J.; Slassi, A.; Jung, G.; Rancourt, J.; Durkin, K.; Liotta, D. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. Tandem Substituted Tetrahydrofuran Formation and Stereoselective Reduction: Synthesis of the C17-C22 Subunit of Ionomycin. J. Org. Chem. 1994, 59(5), 1166-78.
- Lagu, B.; Liotta, D. Surprisingly High Diastereoselection in the Aldol Reactions of Sodium Enolates of a-Amino Methyl Ketones. Tetrahedron Lett. 1994, 35(26), 4485-8.
- El-Kattan, Y.; Goudgaon, N.; Fulcrand, G.; Liotta, D.; Schinazi, R. Synthesis of 5- Carboranyluracil and its Glycosylation with Normal and Modified Carbohydrates. Current Topics in the Chemistry of Boron (Royal Society of Chemistry), 1994, 181-4.
- Bielawska, A.; Crane, H.; Liotta, D.; Obied, L.; Hannun, Y. Selectivity of Ceramide-Mediated Biology: Lack of Activity of Erthro-dihydroceramide. J. Biol. Chem. 1993, 268(35), 26226-32.
- M. Y. Pushkareva, A. Bielawska, D. Menaldino and Y. Hannun. Regulation of Sphingosine- Activated Protein Kinases: Specificity of Activation by Sphingoid Bases and Inhibition by Free Fatty Acids. Biochem. J. 1993, 294 (pt3), 699-703.
- Sperka, J.; Liotta, D. Onium Ions Are Not On The Reaction Coordinate In The Formation Of Heterocycles Via Electrophileinduced Alkenol Cyclizations. Heterocycles, 1993, 35(2), 701-6.
- Mathez, D.; Schinazi, R.; Liotta, D.; Leibowitch, J. Infectious Amplification of Wild Type Human Immunodeficiency Virus from Patients’ Lymphocytes and their Modulation by Reverse Transcriptase Inhibitors In Vitro. Antimicrob. Agents Chemother. 1993, 37(10), 2206-11.
- Wang, J.; Wurster, J.; Wilson, L.; Liotta, D. Stereocontrolled Glycosylations Via Additions of Sulfur Electrophiles to Glycals. Tetrahedron Lett. 1993, 34(31), 4881-4.
- Jones, D; Liotta, D. Episulfonium Ions May Not Be The Stereodeterminants In Glycosylations of 2-Thioalkyl Pyranosides. Tetrahedron Lett. 1993, 34(45), 7209-12.
- Lagu, B.; Crane, H.; Liotta, D. Highly Diastereoselective Aldol Reactions of Chiral Methyl Ketones. J. Org. Chem. 1993, 58(16), 4191-3.
- Wilson, J.; Martin, J.; Borrota-Esoda, K.; Hopkins, S.; Painter, G.; Furman, P. The 5′- Triphosphates of the (-)- and (+)-Enantiomers of Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3- Oxathioan-5-yl]Cytosine Equally Inhibit Human Immunodeficiency Virus Type-1 Reverse Transcriptase. Antimicrob. Agents Chemother. 1993, 37(8), 1720-2.
- Schinazi, R.; Lloyd, R.; Nguyen, M.; Cannon, D.; Ilksoy, N.; Chu, C.; Liotta, D.; Bazmi, H.; Mellors, J. Characterization of Human Immunodeficiency Viruses Resistant to Oxathiolane- Cytosine Nucleosides. Antimicrob. Agents Chemother. 1993, 37(4), 875-81.
- Schinazi, R.; Goudgaon, N.; Soria, J.; Liotta, D. Synthesis, Antiviral Activity, Cytotoxicity and Cellular Pharmacology of 5-Carboranyl-Pyrimidine Nucleosides. Advances in Neutron Capture Therapy, 1993, 285-8.
- Van Roey, P.; Pangborn, W.; Schinazi, R.; Painter, G.; Liotta, D. Absolute Configuration of the Antiviral Agent (-)-Cis-5-Fluoro-1-[2-(Hydroxymethyl)-1,3-Oxathioan-5-yl]Cytosine. Antiviral Chem. Chemother. 1993, 4(6), 369-75.
- Shewach, D.; Liotta, D.; Schinazi, R. Affinity of the Antiviral Enantiomers of Oxathioane Cytosine Nucleosides for Human 2′-Deoxycytidine Kinase. Biochem. Pharmacol. 1993, 45(7), 1540-3.
- Frick, L.; Furman, P.; Liotta, D.; Painter, G.; Firfine, E.; Nelson, D. Pharmacokinetics, Oral Bioavailability and Metabolic Disposition in Rats of 2′-Deoxy-3′-thia-5-fluorocytidine, a Nucleoside Analog Active Against HIV and HBV. Antimicrob. Agents Chemother. 1993, 37(11), 2285-92.
- Wilson, L.; Choi, W.; Spurling, T.; Liotta, D.; Schinazi, R.; Cannon, D.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis and Anti-HIV Activity of Pyrimidine Dioxanyl Nucleoside Analogues. Bioorg. Med. Chem. Lett. 1993, 3(2), 169-74.
- Choi, W.; Yeola, S.; Liotta, D.; Schinazi, R.; Painter, G.; St. Clair, M.; Furman, P. The Synthesis, Anti-HIV and Anti-HBV Activity of Pyrimidine Oxathiolane Nucleoside Analogues. Bioorg. Med. Chem. Lett. 1993, 3(4), 693-6.
- Jones, D.; Liotta, D.; Shinkai, I.; Mathre, D. Origins of the Enantioselectivity Observed in Oxazaborolidine-Catalyzed Reductions of Ketones. J. Org. Chem. 1993, 58(4), 799-801.
- Hager, M.; Liotta, D. An Efficient Synthesis of 3′-Fluoro-3′-deoxythymidine (FLT). Tetrahedron Lett. 1992, 33(47), 7083-6.
- Wurster, J.; Wilson, L.; Morin, G.; Liotta, D. Suppression of Racemization During the Diastereoselective C-3 Functionalization of 5-Hydroxymethyl-2-(5H)-furanones. Tetrahedron Lett. 1992, 33(39), 5689-92.
- Chang, C.; Doong, S.; Zhou, J.; Beach, J.; Jeong, L.; Chu, C.; Liotta, D.; Schinazi, R.; Chang,
- Deoxycytidine deaminase-resistant Stereoisomer is the Active Form of (-)-2′,3′-dideoxy-3′- thiacytidine in the Inhibition of Hepatitus B Replication. J. Biol. Chem. 1992, 267(20), 13938-42.
- Schinazi, R.; McMillan, A.; Cannon, D.; Mathis, R.; Lloyd, R.; Peck, A.; Sommadossi, J.; St. Clair, M.; Wilson, L.; Furman, P.; Choi, W.; Liotta, D. Selective Inhibition of Human Immunodeficiency Viruses by Racemates and Enantiomers of (Cis-5-fluoro-1-{2- hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine. Antimicrob. Agents Chemother. 1992, 36(11), 2423-31.
- Furman, P.; Davis, M.; Liotta, D.; Paff, M.; Frick, L.; Nelson, D.; Dornsife, R.; Wurster, J.; Wilson, L.; Tuttle, J.; Condrey, L.; Averett, D.; Schinazi, R.; Painter, G. The Anti-Hepatitis B Virus Activity, Cytotoxicity and Anabolic Profile of the (-) and (+) Enantiomers of Cis-5-fluoro-1-{2-hydroxymethyl)-1,3-oxythiolane-5-yl}cytosine (FTC). Antimicrob. Agents Chemother. 1992, 36 (12), 2686-92.
- Schinazi, R.; Boudinot, F.; Ibrahim, S.; Manning, C.; McClure, H.; Liotta, D. Pharmacokinetics and Metabolism of Racemic 2′,3′-Dideoxy-5-Fluoro-3′-Thiacytidine in Rhesus Monkeys. Antimicrob. Agents Chemother. 1992, 36(11), 2432-8.
- Hoong, L.; Strange, L.; Liotta, D.; Koszalka, G.; Burns, C.; Schinazi, R. Enzyme-Mediated Enantioselective Preparation of Pure Enantiomers of the Antiviral Agent FTC and Related Compounds. J. Org. Chem. 1992, 57(21), 5563-5.
- Durkin, K.; Liotta, D.; Rancourt, J.; Lavallée, J.; Boisvert, L.; Guindon, Y. Stereoselective Hydrogen Transfer Reactions Involving Acyclic Radicals. A Study of Transition States Using Semi-Empirical Calculations. J. Am. Chem. Soc. 1992, 114(12), 4912-14.
- Wilson, L.; Liotta, D. Diastereoselective Sulfenylation Reactions Employing N – Thiophenyllactams Under Non-Basic Conditions. J. Org. Chem. 1992, 57(7), 1948-50.
- Enkvetchakul, B.; Barnett, T.; Liotta, D.; Geisler, V.; Menaldino, D.; Merrill, A.; Birt,
- Influences of Sphingosine on Two-Stage Skin Tumorigenesis IN SENCAR Mice. Cancer Lett. 1992, 62(1), 35-42.
- Schinazi, R.; Chu, C.; Peck, A.; McMillan, A.; Mathis, A.; Cannon, D.; Jeong, L.; Beach, J.; Choi, W.; Yeola, S.; Liotta, D. Activity of Four Optical Isomers of 2′,3′-Dideoxy-3′-Thiacytidine (BCH-189) Aganist HIV-1 in Human Lymphocytes. Antimicrob. Agents Chemother. 1992, 36(3), 672-6.
- Swiss, K.; Hinkley, W.; Maryanoff, C.; Liotta, D. Complementary Facial Selectivity in Conjugate Additions to g-Hydroxyenones. Synthesis, 1992, (1-2), 127-31.
- Doong, S.; Tsai, C.; Schinazi, R.; Liotta, D.; Cheng, Y. Inhibition of the Replication of Hepatitis B Virus In Vitro by 2′,3′-Dideoxy-3′-thiacytidine and Related Analogues. Proc. Natl. Acad. Sci. U.S.A. 1991, 88(19), 8495-9.
- Choi, W.; Wilson, L.; Yeola, S.; Liotta, D.; Schinazi, R. In Situ Complexation Directs The Stereochemistry of N-Glycosylation in the Synthesis of Thialanyl and Dioxolanyl Nucleoside Analogues. J. Am. Chem. Soc. 1991, 113(24), 9377-9.
- Swiss, K.; Choi, W.; Liotta, D.; Maryanoff, C.; Abdel-Magid, A. Use of Magnesium Cation in Aldol Additions – A Convenient Method for Achieving Anti-Aldol Selectivity. J. Org. Chem.1991, 56(21), 5978-80.
- Merrill, A.; Liotta, D. Lipids as Hormones and Second Messengers. Current Opinions in Structural Biology 1991, 1(4), 516-21.
- Hager, M.; Liotta, D. Cyclization Protocols for Controlling the Glycosidic Stereochemistry of Nucleosides. Application to the Synthesis of the Antiviral Agent, 3′-a-Azidothymidine (AZT). J. Am. Chem. Soc. 1991, 113(13), 5117.
- Goldkorn, T.; Dressler, K.; Muindi, J.; Radin, N.; Mendelsohn, J.; Menaldino, D.; Liotta, D.; Kolesnick, R. Ceramide Stimulates Epidermal Growth Factor Receptor Phosphorylation in A431 Human Epidermoid Carcinoma Cells: Evidence that Ceramide Mediates Sphingosine Action. J. Biol. Chem. 1991, 266(24), 16092-7.
- Liotta, D.; Swiss, K. Addition Reactions with Formation of Carbon-Sulfur or Carbon Selenium Bonds. Comprehensive Organic Chemistry (B. M. Trost, I. Fleming, Ed., S. V. Ley, Vol. Ed.) Pergamon Press, 1991, 7, 515 – 526.
- Stevens, V.; Nimkar, S.; Jamison, W.; Liotta, D.; Merrill, A. Characteristics of the Growth Inhibition and Cytotoxicity of Long-chain (Sphingoid) Bases for Chinese Hamster Ovary Cells: Evidence for an Involvement of Protein Kinase C. Biochim. Biophys. Acta 1990, 1051(1), 37-45.
- Liebeskind, L.; Chidambaram, R.; Nimkar, S.; Liotta, D. A Synthesis of the Abietane Diterpenoid Quinone Royleanone via Maleoylcobalt Technology. Tetrahedron Lett. 1990, 31(26), 3723-6.
- Durkin, K.; Liotta, D. Solvation Controlled Diastereofacial Selectivity in Alkylations of Bicyclic Lactam Enolates. J. Am. Chem. Soc. 1990, 112(22), 8162-3.
- Swiss, K.; Liotta, D.; Maryanoff, C. Mechanistic Aspects of Ligand Assited Nucleophilic Addition Reactions. J. Am. Chem. Soc., 1990, 112(25), 9393-4.
- Durkin, K.; Sherrod, M.; Liotta, D. Empirical Derivation of Molecular Mechanics Parameter Sets: Application to b-Lactams. Advances in Molecular Modeling, 1990, JAI Press, 2, 93-133.
- Wilson, L.; Liotta, D. A General Method for Controlling Glycosylation Stereochemistry in the Synthesis of 2′-Deoxyribose Nucleosides. Tetrahedron Lett. 1990, 31(13), 1815-18.
- Swiss, K.; Choi, W.; Mohan, J.; Barnum, C.; Saindane, M.; Zima, G.; Liotta, D. Reactions Involving Selenium Metal As An Electrophile. Scope and Limitations of the Enolate-Selenolate Transformation. Heteroatom Chem. 1990, 1(2), 141-9.
- Greenberg, P.; Merrill, A.; Grabowski, G.; Liotta, D. Human acid b-Glucosidase: Use of Sphingosyl and N-Alkyl-Glucosylamine Inhibitors to Investigate the Properties of the Active Site. Biochim. Biophys. Acta 1990, 1039(1), 12-20.
- Durkin, K.; Sherrod, M.; Liotta, D. A New Model Parameter Set for β-Lactams. J. Org. Chem. 1989, 54(25), 5839-41.
- Slife, C.; Wang, E.; Hunter, R.; Wang, S.; Burgess, C.; Liotta, D.; Merrill, A. Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum. J. Biol. Chem. 1989, 264(18), 10371-7.
- Rodriguez-Paris, J.; Shoji, M.; Yeola, S.; Liotta, D.; Vogler, W.; Kuo, J. Fluorimetric Studies of Protein Kinase C Interactions with Phospholipids. Biochem. Biophys. Res.Commun. 1989, 159(2), 495-500.
- McCormick, M.; Monahan, R.; Soria, J.; Goldsmith, D.; Liotta, D. Effects of Substitution on Intramolecular Alkoxypalladation Carbonylation Reactions. J. Org. Chem. 1989, 54(19), 4485-7.
- Merrill Jr., A.; Nimkar, S.; Menaldino, D.; Hannun, Y.; Loomis, C.; Bell, R.; Tyagi, S.; Lambeth, J.; Stevens, V.; Hunter, R.; Liotta, D. Structural Requirements for Long-Chain (Sphingoid) Bases as Inhibitors of Protein Kinase C in vitro and Cellular Effects of These Compounds. Biochemistry 1989, 28(8), 3138-45.
- Wilson, E.; Wang, E.; Mullins, R.; Uhlinger, D.; Liotta, D.; Lambeth, J.; Merrill, A. Modulation of the Free Sphingosine Levels in Human Neutrophils by Phorbol Esters and Other Factors. J. Biol. Chem. 1988, 263(19), 9304-9.
- Hoekstra, W.; Zima, G.; Solomon, M.; Liotta, D. The Case Favoring Direct C-Alkylation of Heteroatom-Substituted Enolates. J. Org. Chem. 1988, 53(21), 5058-62.
- Solomon, M.; Jamison, W.; McCormick, M.; Liotta, D.; Cherry, D.; Mills, J.; Shah, R.; Rogers, J.; Maryanoff, C.; Paragamian, V. Ligand Assisted Nucleophilic Additions. Control of Site and Face Attack of Nucleophiles on 4-Oxido Enones. J. Am. Chem. Soc. 1988, 110(11), 3702-4.
- Nimkar, S.; Menaldino, D.; Jamison, W.; Merrill, A.; Liotta, D. A Stereoselective Synthesis of Sphingosine, A Protein Kinase C Inhibitor. Tetrahedron Lett. 1988, 29(25), 3037-40.
- Dunams, T.; Hoekstra, W.; Pentaleri, M.; Liotta, D. Molecular Aggregation and Its Applicability to Synthesis. The Diels-Alder Reaction. Tetrahedron Lett. 1988, 29(31), 3745-8.
- Liotta, D.; Saindane, M.; Waykole, L.; Grossman, J.; Stephens, J. Trajectories of Proton Transfer Reactions. Experimental Determination of the Magnitude of Primary Deuterium Isotope Effects for Proton-transfers Occurring at Acute Angles. J. Am. Chem. Soc. 1988, 110(8), 2667-8.
- Merrill, A.; Wang, E.; Mullins, R.; Jamison, W.; Nimkar, S.; Liotta, D. Quantitation of Free Sphingosine in Liver by High-Performance Liquid Chromatography. Anal. Biochem. 1988, 171(2), 373-81.
- Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction In A Flourocarbon Medium. II. Kinetics of the 1,2,3,4-Tetrahydroquinoline Reaction. Fuel 1987, 66, 1621.
- Liotta, D.; Brown, D.; Hoekstra, W.; Monahan, R. Pyridinium Dichromate-Induced 1,3-Oxidative Rearrangements of Enynols. Tetrahedron Lett. 1987, 28 (10), 1069-72.
- Maryanoff, B.; Nortey, S.; Inners, R.; Campbell, S.; A. B. Reitz and D.C. Liotta. Synthesis of C- Arabinofuranosides. Phosphonate and Carboxylate Isosteres of b-D-Arabinose-1,5- Diphosphate. Carbohydr. Res. 1987, 171, 259-78.
- Reitz, A.; Nortey, S.; Maryanoff, B.; Liotta, D.; Monahan, R. Stereoselectivity of Electrophile- Promoted Cyclizations of g-Hydroxyalkenes. An Investigation of Carbohydrate-Derived and Model Substrates. J. Org. Chem. 1987, 52(19), 4191-4204.
- Liotta, D.; Ott, W. Triene Cyclizations. Total Synthesis of Pallescensin A. Synth. Commun., 1987, 17(14), 1655-65.
- Nucleophilic Selenium in “Organoselenium Chemistry” (Wiley-Interscience), D. Liotta, Ed., 1987, 207-242. Liotta, D.; Monahan, R.; Waykole, L.; Brown, D.
- Liotta, D.; Saindane, M.; Monahan, R.; Brothers, D.; Fivush, A. Rearrangement of α- Phenylselenenyl Ketones. Synth. Commun. 1986, 16 (12), 1461-8.
- Liotta, D.; Saindane, M.; Brothers, D. Based-Induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47 (8), 1598-600.
- Liotta, D.; Monahan, R. Selenium in Organic Synthesis. Science 1986, 231 (4736), 356-61.
- Kaufman, M.; Jamison, W.; Liotta, D. Coal Liquefaction in a Fluorocarbon. 1. Nitrogen Compounds as Hydrogen Transfer Agents. Fuel 1986, 65 (1), 148-50.
- Fraser-Reid, B.; Grossman, J.; Underwood, R.; Osterhout, M.; Liotta, D. Some Observations on the Relative Reactivities of a-Enones of Oxanes and Cyclohexanes. J. Org. Chem. 1986, 51(11), 2152-5.
- Liotta, D; Saindane, M.; Barnum, C.; Zima, G. Synthetic Applications of 2- Phenylselenenylenones. 3. An Overview. Tetrahedron 1985, 41(21), 4881-9.
- Goldsmith, D.; Liotta, D.; Waykole, L.; Hoekstra, W.; Volmer, M. Preparation and Reactivity of α-phenylselenyl Ethers. Tetrahedron 1985, 41 (21), 4873-80.
- Gupton, J.; DeCrexcenzo, G.; Colon, C.; Baran, D.; Dukesherer, D.; Novick, S.; Liotta, D.; Idoux, P. Regioselective fluoroalkoxylation and polyfluoroalkoxylation of aromatic and heteroaromatic polyhalides. Can. J. Chem. 1985, 63 (11), 3037-42.
- Bresciani-Pahor, N.; Calligaris, M.; Randaccio, L.; Marzilli, L.; Summers, M.; Toscano, P.; Grossman, J.; Liotta, D. The 2,2,2-Trifluoroethyl Ligand: A Structural “Reporter” Group for Carbanion Character of Alkyl Ligands in Organometallic Compounds. Organometallics 1985, 4(4), 630-6.
- Liotta, D.; Saindane, M.; Sunay, U.; Jamison, W.; Phillips, P.; Grossman, J. Acetylide Additions to Enediones. Regioselectivity Based on Stereoelectronic Control. J. Org. Chem. 1985, 50 (17), 3241-3.
- Liotta, D. New Organoselenium Methodology. Accounts Chem. Res., 1984, 17(1), 28-34.
- Liotta, D. The Chemistry of 2-Phenylselenenylenones. Proceedings of the Fourth International Conference on the Organic Chemistry of Selenium and Tellurium 1983, 278-96.
- Goldsmith, D.; Liotta, D.; Saindane, M.; Waykole, L.; Bowen, P. 3-Alkylfurans as Useful Synthetic Equivalents for Substituted D2-Butenolides. Tetrahedron Lett. 1983, 24(52), 5835-8.
- Liotta, D.; Arbiser, J.; Short, J.; Saindane, M. A Simple, Inexpensive Procedure for the Large Scale Production of Alkyl Quinones. J. Org. Chem. 1983, 48 (17), 2932-33.
- Liotta, D.; Saindane, M.; Waykole, L. New Probes for Electron Transfer Processes. Evidence Supporting the Single Electron Transfer Mechanism in Additions of Carbanions to Dienones. J. Am. Chem. Soc. 1983, 105 (9), 2922-3.
- Liotta, D.; Saindane, M.; Ott, W. A Simple, Efficient Synthesis of 3-Substituted Furans. Tetrahedron Lett. 1983, 24 (24), 2473-6.
- Menger, F.; Grossman, J.; Liotta, D. Transition State Pliability in N-to-N Proton Transfer. J. Org. Chem. 1983, 48 (6), 905-7.
- Lehman, T.; Bursey, M.; Harvan, D.; Hass, J.; Liotta, D.; Waykole, L. Identity of Collisional Activation Spectra of Some Positive Ions Produced Both by Reversal of Negative Ions and by Decomposition of Positive Ions. Org. Mass. Spec. 1982, 17 (12), 607-11.
- Liotta, D.; Sunay, U.; Ginsberg, S. Phosphonosilylations of Cyclic Enones. J. Org. Chem. 1982, 47(11), 2227-9.
- Liotta, D.; Saindane, M.; Brothers, D. Base-induced Rearrangements of a-Phenylselenenyl Ketones. J. Org. Chem. 1982, 47(8), 1598-1600.
- Liotta, D.; Zima, G.; Saindane, M. The Origins of Regio- and Stereoselectivity in Additions of Phenylselenenyl Chloride to Allylic Alcohols and the Applicability to These Additions to a Simple 1,3-Enone Transposition Sequence. J. Org. Chem. 1982, 47(7), 1258-67.
- Baker, A.; Horozoglu, G.; Guang-Di, Y.; Liotta, D.; Zima, G.; Barnum, C.; Flannagan, N. The Photoelectron Spectra of Alkyl Aryl Selenides. Electronic and Steric Factors in the Observation of Rotamers. J. Org. Chem. 1981, 46(21), 4127-30.
- Liotta, D.; Barnum, C.; Saindane, M. Synthetic Applications of 2-Phenylselenenylenones. 2. The Synthesis of Dihydrojasmone and cis-Jasmone. J. Org. Chem. 1981, 46 (21), 4301-4.
- Liotta, D.; Saindane, M.; Barnum, C.; Ensley, H.; Balakrishan, P. Reactions Involving Selenium Metal as an Electrophile. 2. A General Procedure for the Preparation of Unsaturated b- Dicarbonyl Compounds. Tetrahedron Lett. 1981, 22 (32), 3043-6.
- Liotta, D.; Saindane, M.; Barnum, C. Selective Reactions of Carbanions with p-Quinones. The Aggregate Model. J. Org. Chem. 1981, 46 (16), 3369-70.
- Liotta, D.; Sunay, U.; Santiesteban, H.; Markewicz, W. Phenyl Selenide Anion. A Superior Reagent for SN2-Type Cleavages of Esters and Lactones. J. Org.Chem. 1981, 46 (13), 2605- 10.
- Liotta, D.; Barnum, C.; Puleo, R.; Zima, G.; Bayer, C.; Kezar, H. A Simple Method for the Efficient Synthesis of Unsaturated b-Dicarbonyl Compounds. J. Org. Chem. 1981, 46(14), 2920-3.
- Liotta, D.; Saindane, M.; Barnum, C. Diels-Alder Reactions Involving Cross-Conjugated Dienones. Effects of Substitution on Reactivity. J. Am. Chem. Soc. 1981, 103(11), 3224-6.
- Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-ray Excitation. Anal. Chem. 1980, 52(5), 161R-174R.
- Liotta, D.; Zima, G.; Barnum, C.; Saindane, M. Reactions Involving Selenium Metal as an Electrophile. The Enolate-Selenolate Transformation, Tetrahedron Lett. 1980, 21 (38), 3643-6.
- Liotta, D.; Zima, G.; Barnum, C. Synthetic Applications of 2-Phenylselenenylenones. Selective Formation of Exocyclic or Endocyclic Enones from a Common Intermediate, J. Org. Chem. 1980, 45, 2736.
- Liotta, D.; Zima, G. Synthetic Applications of Phenylselenenyl Chloride Additions. A Simple 1,3- Enone Transposition Sequence. J. Org. Chem. 1980, 45 (13), 2551-3.
- Goldsmith, D.; Liotta, D.; Lee, C.; Zima, G. The Reactions of β,γ-Unsaturated Acids with Phenylselenenyl Chloride. Decarboxylative Elimination vs. Phenylselenolactonization. Tetrahedron Lett. 1979, 50, 4801-4.\
- Zima, G.; Liotta, D. A General Synthesis of 2-Phenylselenenylenones. The Reactions of Unsaturated Ketones with a Phenylselenenyl Chloride/Pyridine Complex. Synth. Commun. 1979, 9 (8), 697-703.
- Liotta, D.; Paty, P.; Johnson, J.; Zima, G. Synthetic Applications of Phenyl(trimethylsilyl)selenide, Tetrahedron Lett. 1978, 51, 5091-4.
- Liotta, D.; Zima, G. An Examination of the Synthetic Utility of Phenylselenenyl Chloride Additions to Olefins. Tetrahedron Lett. 1978, (50), 4977-80.
- Baker, A.; Wong, D.; Lo, S.; Bloch, M.; Horozoglu, G.; Goldman, N.; Engel, R.; Liotta, D. The Reaction N-Aryl Nitrones with Dichloroketene: A New Synthesis of Isatins. Tetrahedron Lett. 1978, 215.
- Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet and X-Ray Excitation. Anal. Chem. 1978, 50 (5), 328R-46R.
- Liotta, D.; Markiewicz, W.; Santiesteban, H. The Generation of Uncomplexed Phenyl Selenide Anion and Its Applicability of SN2-Type Cleavages. Tetrahedron Lett. 1977, (50), 4365-8.
- Liotta, D.; Markiewicz, W.; Santiesteban, H. Nucleophilic Ring Opening of Lactones via SN2- Type Reactions with Uncomplexed Phenyl Selenide Anion. Tetrahedron Lett. 1977, (50) 4369- 72.
- Paquette, L.; Liotta, D.; Liao, C.; Wallis, T.; Eickman, N.; Clardy, J.; Gleiter,
- Endoperoxidation of Conformationally Fixed Norcaradienes by Singlet Oxygen. Frontier Molecular Orbital Basis for the Operability of 1O2 Quenching by Hydrazides. J. Am. Chem. Soc., 1976, 98 (20), 6413-16.
- Paquette, L.; Liao, C.; Liotta, D.; Fristad, W. Reversal of Stereospecificity During Allylic Hydroperoxidation of D3-Norcarene and Bicyclo [4.2.0] Oct-3-ene Derivatives Arising from Structurally Enforced Quenching of Singlet Oxygen by the Hydrazide Functionality. J. Am Chem. Soc. 1976, 98 (20), 6412-14.
- Paquette, L.; Liotta, D.; Baker, A. Frontier Molecular Orbital Basis for the Structurally Dependent Regiospecific Reactions of Singlet Oxygen with Polyolefins. Tetrahedron Lett. 1976, (31), 2681-4.
- Baker, A.; Brisk, M.; Venanzi, T.; Kwon, Y.; Sadka, S. Spiroconjugation Involving Sulfur 3p Atomic Orbitals. Tetrahedron Lett. 1976, 17 (38), 3415-18.
- Baker, A.; Brisk, M.; Liotta, D. Electron Spectroscopy-Ultraviolet Excitation. Anal. Chem. 1976, 48, 281R-94R.
- Liotta, D.; Engel, R. The Thermal Decomposition of Alkoxycarbonyl Thiocyanates and Isothiocyanates. Can. J. Chem. 1975, 53, 907-12.
- Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. The Reactions of N-Aryl Nitrones with Oxalyl Chloride. J. Org. Chem. 1974, 39 (13).
- Liotta, D.; Baker, A.; Goldman, N.; Engel, R. Reactions of N-Aryl Nitrogen Oxides. 1. Selective Ortho-Chlorination in the Reaction of Aryl Nitrones and Amine Oxides with Thionyl Chloride or Phosgene. J. Org. Chem. 1974, 39(18).
- Liotta, D.; Baker, A.; Goldman, N.; Weinstein, F.; Felsen, D.; Engel, R. The Reaction of N-Aryl Nitrones with Thionyl Chloride or Phosgene. J. Org. Chem. 1973, 39, 3445.
- Engel, R.; Santo, T.; Liotta, D.; Freed, D. Enhanced Nucleophilic Displacement in Phosphinite Esters. Chem. Commun. 1970, 646a.
- Engel, R.; Liotta, D. The Thermal Decomposition of Trialkyl Phosphorothioates. J. Chem. Soc. C, 1970, 523.
PATENTS
- NMDA receptor antagonists for neuroprotection. U.S. Patent 9,079,852. 2015. Liotta, D.; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Myers, S.; Tahirovic, Y.
- Chemokine CXCR4 receptor modulators and used related thereto. U.S. Patent 8,969,381. 2015. Wilson, L.; Wiseman, J.; Liotta, D.; Natchus, M.
- Subunit selective NMDA receptor potentiators for the treatment of neurological conditions. U.S. Patent 8,822,462 2014. Liotta, D.; Traynelis, S.; Santangelo, R.; Garnier; E.
- Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds. US Patent 8,507,673 2013. Liotta, D.; Snyder, J.; Jogalekar, A.; Barrett, A.; Fuchter, M.; Cook, M.; Kroll, S.
- NMDA receptor antagonists for neuroprotection. US Patent 8,420,680 2013. Liotta, D.;; Snyder, J.; Traynelis, S.; Wilson, L.; Mosley, C.; Dingledine, R.; Tahirovic, Y.; Myers, S.
- Triptolide analogs for the treatment of autoimmune and inflammatory disorders. US Patent 8,193,249 2012. Liotta, D.; Wang, S.; Snyder, J.; Venkatesan, H.
- 2-fluoronucleosides. US Patent 8,168,583 2012. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
- 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation. US Patent 8,114,994 2012. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.
- CXCR4 antagonists for the treatment of medical disorders. US Patent 8,114,884 2012. Liotta, D.; Shim, H.; Snyder, J.; Zhan, W.; Liang, Z.
- CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders. US Patent 8,080,659 2011. Liotta, D.; Snyder, J. and Zhan, W.
- Selective inhibitors for cyclin-dependent kinases. U.S. Patent 8,067,424. 2011. Liotta, D.; Jogalekar, A.; Snyder, J.; Barrett, A.; Coombes, R.; Ali, S.; Siwicki, A.; Brackow, J.; Scheiper, B.
- 2′-fluoronucleosides. U.S. Patent 7,662,938. 2010. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
- HIV-1 mutations selected for by beta-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,635,690. 2009. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.
- Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 7,577,139. 2009. Liotta, D.; Venkatesan, H.; Snyder, J.; Wang, S.
- 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation. U.S. Patent 7,495,006. 2009. Liotta, D.; Mao, S.; Hager, M.; Schinazi, R.
- Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,468,436. 2008. Liotta, D.; Schinazi, R.; Choi, W.
- 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 7,419,966. 2008. Liotta, D.; Schinazi, R.
- Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3- oxathiolane. U.S. Patent No. 7,402,588. 2008. Liotta, D.; Schinazi, R.; Choi, W.
- pH-dependent NMDA receptor antagonists. U.S. Patent No. 7,375,136. 2008. Liotta, D.; Traynelis, S.; Snyder, J.; Altas, Y.; Mott, D.; Doherty, Jr, J.; Dingledine, R.
- Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 7,371,766. 2008. Liotta, D.; Snyder, R.; Davis, M., Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.
- 2′-fluoronucleosides. U.S. Patent 7,307,065. 2007. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
- Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 7,160,999. 2007. Liotta, D.; Schinazi, R.; Choi, W.
- HIV-1 mutations selected for by beta.-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine. U.S. Patent No. 7,115,584. 2006. Liotta, D.; Schinazi, R.; Hammond, J.; Mellors, J.
- Therapeutic nucleosides. U.S. Patent No. 7,053,100. 2006. Liotta, D.
- Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono- isopropoxide. U.S. Patent No 6,939,965. 2005. Liotta, D.; Painter, G.; Almond, M.; Soria, J.; Sznaidman, M.
- 2′-fluoronucleosides. U.S. Patent 6,911,424. 2005. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
- Therapeutic nucleosides. U.S. Patent No. 6,812,233. 2004. Liotta, D.
- Triptolide analogs for the treatment of autoimmune and inflammatory disorders. U.S. Patent No. 6,777,441. 2004. Liotta, D.; Wang, E.; Snyder, J.; Venkatesan, H.
- Diimino compounds for use as modulators of cell regulation. U.S. Patent 6,750,211. 2004. Liotta, D.; Merrill, A.; Warden, L.
- Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No. 6,720,184. 2004. Liotta, D.; Merrill, Jr., A.;; Wang, E.; Riley, R.
- Method of Resolution and Antiviral Activity of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 6,703, 396 B1. 2004. Liotta, D.; Schinazi, R.; Choi, W.
- 3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith. U.S. Patent No. 6,680,303. 2004. Liotta, D.; Schinazi, R.
- Curcumin analogs with anti-tumor and anti-angiogenic properties. U.S. Patent No. 6,664,272. 2003. Liotta, D.; Snyder, J.; Davis, M.; Adams, B.; Shoji, M.; Ferstl, E.; Sunay, U.
- Antiviral Activity and Resolution of 2-Hydroxymethyl-5-(5-Fluorocytosin-1-YL)-1,3. US Patent 6,642,245, B1 2003. Liotta, D.
- Sphingolipid Derivatives and Their Methods of Use. US Patent 6,610,835, 2003. Liotta, D.; Merrill, A.; Keane, T.; Schmelz, E.; Bhalla, K.
- Method for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,583,292. 2003. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
- Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,576,776. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
- Diiminopiperazine derivatives for use in the modification of sphingolipid metabolism and as modulators of cell regulation. U.S. Patent 6,552,025, 2003. Liotta, D.; Merrill, A.; Warden, L.
- Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,518,425. 2003. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
- Compositions and Methods for Targeting Phamaceutically Active Materials to Cells Containing Androgen Receptors. US Patent 6,468,981, 2002. Liotta, D.; Petros, J.
- Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent No. 6,399,783. 2002. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
- 5-Carboxamido or 5-Fluoro-2’,3’-Unsaturated or 3’-Modified-Pyrimidine Nucleosides. US Patent 6,391,859, 2002. Liotta, D.; Schinazi, R.
- 2′-Fluoronucleosides. U.S. Patent No. 6,348,587. 2002. Liotta, D.; Schinazi, R.; Chu, C.; McAtee, J.; Shi, J.; Choi, Y.; Lee, K.; Hong, J.
- Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers. U.S. Patents 6,346,627. 2002. Liotta, D.; Schinazi, R.; Choi, W.
- Treatment of HIV by administration of beta.-D-2′, 3′-didehydro-2′,3′-dideoxy-5- fluorocytidine (D4FC). U.S. Patent No. 6,232,300. 2001. Liotta, D.; Schinazi, R.
- Method of manufacture of 1,3-oxathiolane nucleosides. U.S. Patent No. 6,215,004. 2001. Liotta, D.; Painter, G.; Almond, M.; Cleary, D.; Soria, J.; Sznaidman, M.
- Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 6,153,751. 2000. Liotta, D.; Choi, W.
- Polycationic oligomers. U.S. Patent No. 6,153,596. 2000. Liotta, D.; Petros, J.; Wey, S.; Karr, J.; Pohl, J.
- Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents. U.S. Patent 6,150,537. 2000. Liotta, D.; Venkatesan, H.; Captain, L.; Voronkov, M.; Snyder, J.; Schestopol, M.
- Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination. U.S. Patent No 6,127,578. 2000. Liotta, D.; Merrill Jr., A.; Wang, E.; Riley, R.
- Antiviral activity and resolution of 2-hydroxymethyl-5-(5-flurocytosin-1-yl)-1,3- oxathiolane. U.S. Patent No. 6,114,343. 2000. Liotta, D.; Schinazi, R.; Choi, W.
- Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers. U.S. Patent No. 6,069,252. 2000. Liotta, D.; Schinazi, R.; Choi, W.
- Diastereoselective synthesis hydroxyethylene dipeptide isosteres. U.S. Patents No. 5,990,341. 1999. Liotta, D.; Lagu, B.
- Method and compositions for the synthesis of BCH-189 and related compounds. U.S. Patent No. 5,914,400. 1999. Liotta, D.; Choi, W.
- Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3- oxathiolane. U.S. Patents 5,914,331. 1999. Liotta, D.; Schinazi, R.; Choi, W.
- [5–Caboxamido or 5–fluoro]–[2′, 3′–unsaturated or 3′–modified]–pyrimidine nucleosides. U. S. Patent No. 5,905,070. 1999. Liotta, D.; Schinazi, R.
- Treatment of Urogenital Cancer with Boron Neutron Capture. U.S. Patent 5,872,107, 1999. Liotta, D.; Schinazi, R.; Keane, T.
- Method of Resolution and Antiviral Activity of 1.3-Oxathiolane Nucleoside Enantiomers. U.S. Patent 5,892,025, 1998. Liotta, D.; Schinazi, R.; Choi, W.
- Antiviral 1.3-Dioxolane Nucleoside Analogues. U.S. Patent 5,852,027, 1998. Liotta, D.
- Method of resolution of 1,3-oxathiolane nucleoside enantiomers. U. S. Patent 5,827,727. 1998. Liotta, D.; Schinazi, R.; Choi, W.; Cheng, Y.
- Method for the synthesis, compositions and use of 2′-deoxy-5-fluoro-3′-thiacytidine and related compounds. U.S. Patent 5,814,639. 1998. Liotta, D.; Schinazi, R.; Choi, W.
- Method of Resolution of 1,3-Oxathiolane Nucleoside Enantiomers. US Patent 5,728,575, 1998. Liotta, D.; Choi, W.
- Compositions Containing 5-Fluoro-2’,3’-Didehydro-2’,3’-Dideoxycytidine Or A Mon-, Di-, Or Triphosphate Thereof And A Second Antiviral Agent. US Patent 5703058, 1997. Liotta, D.; Schinazi, D.
- Method for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacyctidine and Related Compounds. U.S. Patent. 5,700,937, 1997. Liotta, D.; Choi, W.; Schinazi, R.
- One Vessel Stereoselective Glycosylation of Purines and Pyrimidines. U. S. Patent 5,602,245, 1997. Wurster, J.; Wang, J.; Wilson, L.
- Treatment of urogenital cancer with boron neutron capture therapy. U.S. Patent 5,599,796. 1997. Liotta, D.; Schinazi, R.; Keane, T.
- Diastereoselective synthesis of hydroxyethylene dipeptide isosteres. U.S. Patent 5,587,514. 1996. Liotta, D.; Lagu, B.
- Method and Composition for the Synthesis of BCH-189 and Related Compounds. European Patent 5,539,116, 1996. Liotta, D.; Choi, W.
- 4-Arylisoindole Analgesics. U.S. Patent 5,508,424, 1996. Liotta, D.; Carmosin, R.; Carson, J.; Pitis, P.; Raffa, R.
- Sensitizing agents for use in boron neutron capture therapy. U.S. Patent No. 5,462,724. 1995. Liotta, D.; Schinazi, R.
- Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,432,273, 1995. Liotta, D.; Hager, M.
- Preparation of 3’-Substituted-2’,3’-Dideoxynucleosides and 2’-Deoxynucleosides from Acyclic, Achiral Precursors. U. S. Patent No. 5,414,078, 1995. Liotta, D.; Hager, M.
- Novel Sensitizing Agents for Boron Neutron Capture Therapy. U.S. Patent No. 5,405,598, 1995. Liotta, D.; Schinazi, R.
- Methods of Synthesis of 1,3-Dioxolane Nucleosides. U. S. Patent No. 5,276,151, 1994. Liotta, D.
- Method of Altering Sphingolipid Metabolism and Detecting Fumonisin. U.S. Patent 5,232,837, 1993. Liotta, D.
- Methods for the Synthesis, Composition and Use of 2′-Deoxy-5-Fluoro-3′-Thiacytidine and Related Compounds. U. S. Patent No. 5,210,085 1993. Liotta, D.; Schinazi, R.; Choi, W.
- Method and Compositions for the Synthesis of BCH-189 and Related Compounds. U. S. Patent No. 5204466, 1993. Liotta, D.; Choi, W.
- Method of Preparing Sphingosine Derivatives. U. S. Patent 5,110,987, 1992. Liotta, D.; Merrill, A.
- 1,2-1,4 Addition Reaction Sequence Leading to Diphenylacetylenes. U.S. Patent 4,772,755 1988. Liotta, D.; Maryanoff, C.; Paragamian, V.